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2023年7月 第38卷 第7期11
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血清外泌体中GP1BA的表达水平与动脉粥样硬化的相关性分析

来源期刊: 广州医药 | 95-100 发布时间:2023-11-07 收稿时间:2025/11/13 18:30:24 阅读量:130
作者:
关键词:
GP1BA炎症因子动脉粥样硬化相关性分析
DOI:
10.3969/j.issn.1000-8535.2023.10.015
收稿时间:
2023-03-21 
修订日期:
 
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引用总数:
0  
目的 探讨血清外泌体中糖蛋白 Ib 血小板亚基α(GP1BA)的表达水平与动脉粥样硬化的相关性。方法 选取福州市第二医院2022年1月—2023年1月收治的30例心电图提示ST-T改变及冠状动脉造影显示有AS斑块的患者为动脉粥样硬化组;30名健康志愿者为对照组。实时荧光定量(RT-qPCR)法和蛋白质印迹(WB)检测受试人员血清外泌体中GP1BA的表达量,ELISA法检测血清中肿瘤坏死因子α(TNF-α)、白细胞介素-1β(IL-1β)、干扰素-γ(IFN-γ)、高敏心肌肌钙蛋白(hs-cTnT)、血管性血友病因子(vWF)含量。采用Pearson相关系数分析血清外泌体中GP1BA的表达水平与TNF-α、IL-1β、IFN-γ、hs-cTnT、vWF的相关性。结果 动脉粥样硬化组血清外泌体中GP1BA的表达水平高于对照组,血清中TNF-α、IL-1β、IFN-γ、hs-cTnT、vWF含量升高(均P<0.05)。相关性分析发现GP1BA的表达水平与TNF-α、IL-1β、IFN-γ、hs-cTnT、vWF含量均呈较强正相关关系(均P<0.05)。结论 血清外泌体中GP1BA的表达水平与AS存在相关性,并可作为AS的潜在标志物。
1、 张晓霞. 双抗血小板联合阿托伐他汀治疗对高龄冠心病PCI术后患者颈动脉硬化斑块及心肌功能的影响[J].国际医药卫生导报,2017,23(6):869-872. 张晓霞. 双抗血小板联合阿托伐他汀治疗对高龄冠心病PCI术后患者颈动脉硬化斑块及心肌功能的影响[J].国际医药卫生导报,2017,23(6):869-872.
2、 SALUK-BIJAK J,DZIEDZIC A,BIJAK M.Pro-Thrombotic Activity of Blood Platelets in Multiple Sclerosis[J].Cells,2019,8(2):110. SALUK-BIJAK J,DZIEDZIC A,BIJAK M.Pro-Thrombotic Activity of Blood Platelets in Multiple Sclerosis[J].Cells,2019,8(2):110.
3、 杨春梅,张小如.降脂方调血脂、预防动脉粥样硬化的作用及对肝脏转氨酶的影响[J].中医研究,2022,35(9):74-78. 杨春梅,张小如.降脂方调血脂、预防动脉粥样硬化的作用及对肝脏转氨酶的影响[J].中医研究,2022,35(9):74-78.
4、 ZHANG Q,WANG L,WANG S,et al.Signaling pathways and targeted therapy for myocardial infarction[J].Signal Transduct Target Ther,2022,7(1):78. ZHANG Q,WANG L,WANG S,et al.Signaling pathways and targeted therapy for myocardial infarction[J].Signal Transduct Target Ther,2022,7(1):78.
5、 HAN L,LAM E W,SUN Y.Extracellular vesicles in the tumor microenvironment: Old stories,but new tales[J].Mol Cancer,2019,18(1):59. HAN L,LAM E W,SUN Y.Extracellular vesicles in the tumor microenvironment: Old stories,but new tales[J].Mol Cancer,2019,18(1):59.
6、 KALLURI R,LEBLEU V S.The biology,function,and biomedical applications of exosomes[J].Science,2020,367(6478):eaau6977. KALLURI R,LEBLEU V S.The biology,function,and biomedical applications of exosomes[J].Science,2020,367(6478):eaau6977.
7、 PLUCHINO S,SMITH J A.Explicating Exosomes: Reclassifying the Rising Stars of Intercellular Communication[J].Cell,2019,177(2):225-227. PLUCHINO S,SMITH J A.Explicating Exosomes: Reclassifying the Rising Stars of Intercellular Communication[J].Cell,2019,177(2):225-227.
8、 LIBBY P,BURING J E,BADIMON L,et al.Atherosclerosis[J].Nat Rev Dis Primers,2019,5(1):56. LIBBY P,BURING J E,BADIMON L,et al.Atherosclerosis[J].Nat Rev Dis Primers,2019,5(1):56.
9、 BELCHER A,ZULFIKER A H M,LI O Q,et al.Targeting thymidine phosphorylase with tipiracil Hydrochloride attenuates thrombosis without increasing risk of bleeding in mice[J].Arterioscler Thromb Vasc Biol,2021,41(2): 668-682. BELCHER A,ZULFIKER A H M,LI O Q,et al.Targeting thymidine phosphorylase with tipiracil Hydrochloride attenuates thrombosis without increasing risk of bleeding in mice[J].Arterioscler Thromb Vasc Biol,2021,41(2): 668-682.
10、 CHEN Y T,YUAN H X,OU Z J,et al.Microparticles(exosomes) and atherosclerosis[J].Curr Atheroscler Rep,2020,22(6): 23. CHEN Y T,YUAN H X,OU Z J,et al.Microparticles(exosomes) and atherosclerosis[J].Curr Atheroscler Rep,2020,22(6): 23.
11、 WANG C,LI Z,LIU Y,et al.Exosomes in atherosclerosis:Performers,bystanders,biomarkers,and therapeutic targets[J].Theranostics,2021,11(8):3996-4010. WANG C,LI Z,LIU Y,et al.Exosomes in atherosclerosis:Performers,bystanders,biomarkers,and therapeutic targets[J].Theranostics,2021,11(8):3996-4010.
12、 LINNA-KUOSMANEN S,TOMAS BOSCH V,MOREAU P R,et al.NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli[J].Cardiovasc Res,2021,117(5): 1339-1357. LINNA-KUOSMANEN S,TOMAS BOSCH V,MOREAU P R,et al.NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli[J].Cardiovasc Res,2021,117(5): 1339-1357.
13、 KE X,LIAO Z,LUO X,et al.Endothelial colony-forming cell-derived exosomal miR-21-5p regulates autophagic flux to promote vascular endothelial repair by inhibiting SIPL1A2 in atherosclerosis[J].Cell Commun Signal,2022,20(1): 30. KE X,LIAO Z,LUO X,et al.Endothelial colony-forming cell-derived exosomal miR-21-5p regulates autophagic flux to promote vascular endothelial repair by inhibiting SIPL1A2 in atherosclerosis[J].Cell Commun Signal,2022,20(1): 30.
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