您的位置: 首页 > 2023年12月 第54卷 第12期 > 文字全文
2023年7月 第38卷 第7期11
目录

柚皮素通过自噬抑制乳腺癌细胞增殖的作用机制

来源期刊: 广州医药 | 89-95 发布时间:2024-01-10 收稿时间:2025/11/13 18:28:33 阅读量:52
作者:
关键词:
柚皮素自噬凋亡乳腺癌
DOI:
10.3969/j.issn.1000-8535.2023.12.015
收稿时间:
2023-05-21 
修订日期:
 
接收日期:
 
引用总数:
7  
目的 探讨柚皮素对人乳腺癌细胞株MCF-7和小鼠乳腺癌细胞系4T1的作用机制。方法 选择人乳腺癌细胞株MCF-7和小鼠乳腺癌细胞系4T1为实验对象,设置对照组和柚皮素组,其中柚皮素组分为20、40、80 和120 μmol/L 4个浓度,利用CCK-8、平板克隆形成实验检测柚皮素对乳腺癌细胞的增殖作用,应用流式细胞术检测柚皮素对乳腺癌细胞的凋亡作用。建立乳腺癌移植瘤模型,应用柚皮素作用于模型小鼠,探讨柚皮素在体内抗肿瘤作用。通过荧光定量PCR和蛋白免疫印迹实验检测自噬相关基因,分析其作用机制。结果 经柚皮素处理后,乳腺癌细胞的增殖明显受到抑制,正常乳腺癌细胞增殖情况变化不大,MCF-7乳腺癌细胞和小鼠乳腺癌4T1均出现明显的凋亡(P<0.001)。结论 柚皮素可以抑制乳腺癌细胞的增殖,且对正常乳腺细胞无明显毒副作用。柚皮素通过凋亡和自噬方式促进乳腺癌细胞的死亡,体内实验结果显示柚皮素具有抗肿瘤作用,并可促进其坏死。
1、 PATELIYA B,BURADE V,GOSWAMI S.Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo[J].Eur J Pharmacol,2021(891):173725. PATELIYA B,BURADE V,GOSWAMI S.Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo[J].Eur J Pharmacol,2021(891):173725.
2、 PATELIYA B,BURADE V,GOSWAMI S.Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma:An experimental study[J].Naunyn Schmiedebergs Arch Pharmacol,2021,394(9):1949-1961. PATELIYA B,BURADE V,GOSWAMI S.Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma:An experimental study[J].Naunyn Schmiedebergs Arch Pharmacol,2021,394(9):1949-1961.
3、 XU Z,HUANG B,LIU J,et al.Combinatorial anti-proliferative effects of tamoxifen and naringenin:The role of four estrogen receptor subtypes[J].Toxicology,2018(410):231-246. XU Z,HUANG B,LIU J,et al.Combinatorial anti-proliferative effects of tamoxifen and naringenin:The role of four estrogen receptor subtypes[J].Toxicology,2018(410):231-246.
4、 ZHANG F,DONG W,ZENG W,et al.Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation[J].Breast Cancer Res,2016,18(1):38. ZHANG F,DONG W,ZENG W,et al.Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation[J].Breast Cancer Res,2016,18(1):38.
5、 QI Z,KONG S,ZHAO S,et al.Naringenin inhibits human breast cancer cells(MDA-MB-231)by inducing programmed cell death,caspase stimulation,G2/M phase cell cycle arrest and suppresses cancer metastasis[J].Cell Mol Biol(Noisy-le-grand),2021,67(2):8-13. QI Z,KONG S,ZHAO S,et al.Naringenin inhibits human breast cancer cells(MDA-MB-231)by inducing programmed cell death,caspase stimulation,G2/M phase cell cycle arrest and suppresses cancer metastasis[J].Cell Mol Biol(Noisy-le-grand),2021,67(2):8-13.
6、 LI Q,WANG Y,ZHANG L,et al.Naringenin exerts anti-angiogenic effects in human endothelial cells:Involvement of ERRα/VEGF/KDR signaling pathway[J].Fitoterapia,2016(111):78-86. LI Q,WANG Y,ZHANG L,et al.Naringenin exerts anti-angiogenic effects in human endothelial cells:Involvement of ERRα/VEGF/KDR signaling pathway[J].Fitoterapia,2016(111):78-86.
7、 ZHAO Z,JIN G,GE Y,et al.Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways.Inflamopharmacology[J].2019,27(5):1021-1036. ZHAO Z,JIN G,GE Y,et al.Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways.Inflamopharmacology[J].2019,27(5):1021-1036.
8、 WANG R,WANG J,DONG T,et al.Naringenin has a chemoprotective effect in MDA-MB-231 breast cancer cells via inhibition of caspase-3 and -9 activities[J].Oncol Lett,2019,17(1):1217-1222. WANG R,WANG J,DONG T,et al.Naringenin has a chemoprotective effect in MDA-MB-231 breast cancer cells via inhibition of caspase-3 and -9 activities[J].Oncol Lett,2019,17(1):1217-1222.
9、 AHAMAD M S,SIDDIQUI S,JAFRI A,et al.Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest[J].PLoS One,2014,9(10):e110003. AHAMAD M S,SIDDIQUI S,JAFRI A,et al.Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest[J].PLoS One,2014,9(10):e110003.
10、 OZYüREK M,AKP?NAR D,BENER M,et al.Novel oxime based flavanone,naringin-oxime:Synthesis,characterization and screening for antioxidant activity[J].Chem Biol Interact,2014(212):40-46. OZYüREK M,AKP?NAR D,BENER M,et al.Novel oxime based flavanone,naringin-oxime:Synthesis,characterization and screening for antioxidant activity[J].Chem Biol Interact,2014(212):40-46.
11、 ZHANG J,WANG N,ZHENG Y,et al.Naringenin in Si-Ni-San formula inhibits chronic psychological stress-induced breast cancer growth and metastasis by modulating estrogen metabolism through FXR/EST pathway[J].J Adv Res,2023(47):189-207. ZHANG J,WANG N,ZHENG Y,et al.Naringenin in Si-Ni-San formula inhibits chronic psychological stress-induced breast cancer growth and metastasis by modulating estrogen metabolism through FXR/EST pathway[J].J Adv Res,2023(47):189-207.
12、 KIM S,PARK T I.Naringenin:A partial agonist on estrogen receptor in T47D-KBluc breast cancer cells[J].Int J Clin Exp Med,2013,6(10):890-899. KIM S,PARK T I.Naringenin:A partial agonist on estrogen receptor in T47D-KBluc breast cancer cells[J].Int J Clin Exp Med,2013,6(10):890-899.
13、 KUIPER G G,LEMMEN J G,CARLSSON B,et al.Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta[J].Endocrinology,1998,139(10):4252-4263. KUIPER G G,LEMMEN J G,CARLSSON B,et al.Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta[J].Endocrinology,1998,139(10):4252-4263.
14、 ZOU W,LUO Y,LIU M,et al.Human intestinal microbial metabolism of naringin[J].Eur J Drug Metab Pharmacokinet,2015,40(3):363-367. ZOU W,LUO Y,LIU M,et al.Human intestinal microbial metabolism of naringin[J].Eur J Drug Metab Pharmacokinet,2015,40(3):363-367.
15、 BHIA M,MOTALLEBI M,ABADI B,et al.Naringenin nano-delivery systems and their therapeutic applications[J].Pharmaceutics,2021,13(2):291. BHIA M,MOTALLEBI M,ABADI B,et al.Naringenin nano-delivery systems and their therapeutic applications[J].Pharmaceutics,2021,13(2):291.
1、欧阳李茜.苯并二氢吡喃酮衍生物和苯并烯氟菌唑关键中间体的制备研究[D].西华大学,2024.DOI:10.27411/d.cnki.gscgc.2024.000171. 欧阳李茜.苯并二氢吡喃酮衍生物和苯并烯氟菌唑关键中间体的制备研究[D].西华大学,2024.DOI:10.27411/d.cnki.gscgc.2024.000171.
2、白会恩.升血小板胶囊治疗难治性血热妄行证原发免疫性血小板减少症的临床研究及机制探讨[D].天津中医药大学,2024.DOI:10.27368/d.cnki.gtzyy.2024.000791. 白会恩.升血小板胶囊治疗难治性血热妄行证原发免疫性血小板减少症的临床研究及机制探讨[D].天津中医药大学,2024.DOI:10.27368/d.cnki.gtzyy.2024.000791.
3、于佳颖.柚皮素激活RIG-Ⅰ介导的信号通路改善PRRSV感染天然免疫抑制机制探究[D].吉林大学,2024.DOI:10.27162/d.cnki.gjlin.2024.006764. 于佳颖.柚皮素激活RIG-Ⅰ介导的信号通路改善PRRSV感染天然免疫抑制机制探究[D].吉林大学,2024.DOI:10.27162/d.cnki.gjlin.2024.006764.
4、刘昌栋.抗癌止痛方外治气滞血瘀型胃癌中度癌性疼痛的临床研究与机制分析[D].扬州大学,2025.DOI:10.27441/d.cnki.gyzdu.2025.003245. 刘昌栋.抗癌止痛方外治气滞血瘀型胃癌中度癌性疼痛的临床研究与机制分析[D].扬州大学,2025.DOI:10.27441/d.cnki.gyzdu.2025.003245.
5、张馨月.基于数据挖掘和网络药理学技术分析肝郁脾虚型乳腺癌的中医用药规律及机制[D].广西中医药大学,2025.DOI:10.27879/d.cnki.ggxzy.2025.000601. 张馨月.基于数据挖掘和网络药理学技术分析肝郁脾虚型乳腺癌的中医用药规律及机制[D].广西中医药大学,2025.DOI:10.27879/d.cnki.ggxzy.2025.000601.
6、尹怡林.柚皮素通过调控Keap1/Nrf2/ARE通路减轻LPS诱导禽肺炎氧化损伤的作用机制研究[D].东北农业大学,2025.DOI:10.27010/d.cnki.gdbnu.2025.000662. 尹怡林.柚皮素通过调控Keap1/Nrf2/ARE通路减轻LPS诱导禽肺炎氧化损伤的作用机制研究[D].东北农业大学,2025.DOI:10.27010/d.cnki.gdbnu.2025.000662.
7、龚兴鑫,严毅鹏,吕敏,等.非靶向代谢组学揭示南昆山毛叶茶绿茶和红茶的独特化学成分组成[J].食品科学,2024,45(19):112-122. 龚兴鑫,严毅鹏,吕敏,等.非靶向代谢组学揭示南昆山毛叶茶绿茶和红茶的独特化学成分组成[J].食品科学,2024,45(19):112-122.
上一篇
下一篇
出版者信息








《广州医药》公众号
目录