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布托啡诺用于剖宫产围术期寒战患者治疗中的有效剂量分析

Analysis of effective dose of butorphanol in the treatment of perioperative shivering patients underwent cesarean section

来源期刊: 广州医药 | 40-44 发布时间:2022-04-12 收稿时间:2025/11/13 18:26:07 阅读量:12
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关键词:
剖宫产布托啡诺寒战最佳剂量不良反应血流动力学
cesarean sectionbutorphanolshiveringoptimal doseadverse reactionshemodynamics
DOI:
10.3969/j.issn.1000-8535.2022.01.008
收稿时间:
2021-03-28 
修订日期:
 
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引用总数:
1  
目的 探讨剖宫产围术期患者采用布托啡诺治疗寒战的最佳剂量。方法 选取2019年10月—2020年11月期间于本院分娩的150例剖宫产妇女作为研究对象,按照随机数字表法分为A组、B组、C组,各组50例。A组给予0.01 mg/kg布托啡诺静脉注射,B组给予0.02 mg/kg,C组给予0.03 mg/kg。比较3组临床疗效、血流动力学、镇静(Ramesay)评分、不良反应、新生儿Apgar评分。结果 3组治疗有效率、 血流动力学、T1、T2时间段Ramesay评分及1 min、5 min、10 min 新生儿Apgar评分比较,差异无统计学意义(P>0.05);C组不良反应发生率高于B组与A组(P<0.05);T3时间段Ramesay评分C组<B组<A组(P<0.05)。结论 0.02 mg/kg剂量布托啡诺治疗剖宫产围术期寒战效果最为理想,产妇围术期血流动力学稳定,不良反应较轻,且对新生儿无明显影响。
Objective To investigate the optimal dose of butorphanol in the treatment of shivering in patients underwent cesarean section. Methods A total of 150 women with cesarean section in our hospital from October 2019 to November 2020 were selected as the research objects, and were divided into group A, group B and group C according to random number table method, with 50 cases in each group. Group A was given 0.01 mg/kg butorphanol intravenously, group B was given 0.02 mg/kg, and group C was given 0.03 mg/kg. Clinical efficacy, hemodynamics, sedation (Ramesay) scores, adverse drug reactions (ADR) and neonatal Apgar scores were compared among the three groups. Results There were no significant differences in effective rate, hemodynamics, Ramesay scores at T1 and T2 time periods and Apgar scores of neonates at 1 min, 5 min and 10 min among the three groups (P>0.05). The incidence of ADR in group C was higher than that in group B and A (P<0.05). Ramesay score at time of T3 of group C was lower than group B and group A (P<0.05). Conclusion The 0.02 mg/kg dose of butorphanol in the treatment of perioperative shivering in cesarean section was the most ideal dose, perioperative hemodynamics of puerpera was stable, adverse reactions were mild, and there was no obvious influence on neonates.
1、 杨林,孙德峰,何颖,等.不同剂量布托啡诺经鼻给药超前镇痛对老年患者苏醒期术后寒战发病率的影响[J].中国现代医学杂志,2018,28(4):91-96. 杨林,孙德峰,何颖,等.不同剂量布托啡诺经鼻给药超前镇痛对老年患者苏醒期术后寒战发病率的影响[J].中国现代医学杂志,2018,28(4):91-96.
2、 CHANG W Y, LI H Y. Anesthetic efficacy of propofol combined butorphanol in laparoscopic surgery for ectopic pregnancy: a protocol of systematic review and meta-analysis[J]. Medicine (Baltimore), 2020, 99 (20) : e20289. CHANG W Y, LI H Y. Anesthetic efficacy of propofol combined butorphanol in laparoscopic surgery for ectopic pregnancy: a protocol of systematic review and meta-analysis[J]. Medicine (Baltimore), 2020, 99 (20) : e20289.
3、 JI J, LIN W, VRUDHULA A, et al. Molecular interaction between butorphanol and κ-opioid receptor[J]. Anesth Analg, 2020, 131 (3) : 935-942. JI J, LIN W, VRUDHULA A, et al. Molecular interaction between butorphanol and κ-opioid receptor[J]. Anesth Analg, 2020, 131 (3) : 935-942.
4、 YADAV J, REGMI M C, BASNET P, et al. Butorphanol in labour analgesia[J]. J Nepal Med Assoc, 2018, 56 (214) : 940-944. YADAV J, REGMI M C, BASNET P, et al. Butorphanol in labour analgesia[J]. J Nepal Med Assoc, 2018, 56 (214) : 940-944.
5、 孙玉峰.不同剂量布托啡诺复合舒芬太尼用于腹腔镜子宫全切术后镇痛的临床研究[J].医学临床研究,2019,36(9):1796-1797. 孙玉峰.不同剂量布托啡诺复合舒芬太尼用于腹腔镜子宫全切术后镇痛的临床研究[J].医学临床研究,2019,36(9):1796-1797.
6、 王刚,杜洪印,丁梅,等. TAP阻滞联合布托啡诺PCIA用于全麻剖宫产术后镇痛的效果[J].中华麻醉学杂志,2019,39(2):189-191. 王刚,杜洪印,丁梅,等. TAP阻滞联合布托啡诺PCIA用于全麻剖宫产术后镇痛的效果[J].中华麻醉学杂志,2019,39(2):189-191.
7、 吕顺,孙德峰.布托啡诺临床应用的研究进展[J].中华麻醉学杂志,2020,40(4):509-512. 吕顺,孙德峰.布托啡诺临床应用的研究进展[J].中华麻醉学杂志,2020,40(4):509-512.
8、 曾磊.布托啡诺对腰硬联合麻醉剖宫产术后寒战的疗效观察[J].临床合理用药杂志,2020,13(5):105-106. 曾磊.布托啡诺对腰硬联合麻醉剖宫产术后寒战的疗效观察[J].临床合理用药杂志,2020,13(5):105-106.
9、 ZHU J, XU C, WANG X, et al. Comparison of the analgesic effects of dezocine, tramadol and butorphanol after cesarean section[J]. Pak J Pharm Sci, 2018, 31 (5) : 2191-2195. ZHU J, XU C, WANG X, et al. Comparison of the analgesic effects of dezocine, tramadol and butorphanol after cesarean section[J]. Pak J Pharm Sci, 2018, 31 (5) : 2191-2195.
10、 郭庆艳,马俊峰,胡朝霞,等.不同剂量布托啡诺联合舒芬太尼镇痛对老年全子宫切除病人术后翻身痛及不良反应的影响[J].实用老年医学,2017,31(9):876-878. 郭庆艳,马俊峰,胡朝霞,等.不同剂量布托啡诺联合舒芬太尼镇痛对老年全子宫切除病人术后翻身痛及不良反应的影响[J].实用老年医学,2017,31(9):876-878.
11、 王刚,杜洪印,丁梅,等. TAP阻滞联合布托啡诺PCIA用于全麻剖宫产术后镇痛的效果[J].中华麻醉学杂志,2019,39(2):189-191. 王刚,杜洪印,丁梅,等. TAP阻滞联合布托啡诺PCIA用于全麻剖宫产术后镇痛的效果[J].中华麻醉学杂志,2019,39(2):189-191.
12、 MANNE V S, GONDI S R. Comparison of butorphanol and fentanyl for the relief of postoperative shivering associated with spinal anesthesia[J]. Anesth Essays Res, 2017, 11 (1) : 84-87. MANNE V S, GONDI S R. Comparison of butorphanol and fentanyl for the relief of postoperative shivering associated with spinal anesthesia[J]. Anesth Essays Res, 2017, 11 (1) : 84-87.
13、 毛毛,李彩娟,沈晓凤,等.不同剂量布托啡诺用于剖宫产术后自控镇痛效果的比较[J].国际麻醉学与复苏杂志,2018,39(4):294-298. 毛毛,李彩娟,沈晓凤,等.不同剂量布托啡诺用于剖宫产术后自控镇痛效果的比较[J].国际麻醉学与复苏杂志,2018,39(4):294-298.
14、 寇广海.布托啡诺复合咪达唑仑用于产妇腰硬联合麻醉后寒战临床研究[J].中国药业,2018,27(5):49-51. 寇广海.布托啡诺复合咪达唑仑用于产妇腰硬联合麻醉后寒战临床研究[J].中国药业,2018,27(5):49-51.
15、 赵小芬.布托啡诺治疗剖宫产麻醉后寒战疗效分析[J].现代医药卫生,2020,36(2):91-92. 赵小芬.布托啡诺治疗剖宫产麻醉后寒战疗效分析[J].现代医药卫生,2020,36(2):91-92.
16、 THIGPEN J C, ODLE B L, HARIRFOROOSH S.Opioids: A review of pharmacokinetics and pharmacodynamics in neonates, infants, and children[J]. Eur J Drug Metab Pharmacokinet, 2019, 44 (5) : 591-609. THIGPEN J C, ODLE B L, HARIRFOROOSH S.Opioids: A review of pharmacokinetics and pharmacodynamics in neonates, infants, and children[J]. Eur J Drug Metab Pharmacokinet, 2019, 44 (5) : 591-609.
17、 陈丽娜,谭媚月,陶倩云,等.布托啡诺近期的临床研究进展[J].中国医师进修杂志,2018,41(12):1147-1152. 陈丽娜,谭媚月,陶倩云,等.布托啡诺近期的临床研究进展[J].中国医师进修杂志,2018,41(12):1147-1152.
18、 王茂林,郭金丽,石秀红.椎管内麻醉后寒战的影响因素及临床治疗分析[J].临床医学研究与实践,2017,2(19):95-96. 王茂林,郭金丽,石秀红.椎管内麻醉后寒战的影响因素及临床治疗分析[J].临床医学研究与实践,2017,2(19):95-96.
1、解立杰,孙敏,姚光,等.加温碘伏消毒联合布托啡诺对腰-硬联合麻醉剖宫产产妇寒战的影响[J].吉林医学,2023,44(07):1874-1877. 解立杰,孙敏,姚光,等.加温碘伏消毒联合布托啡诺对腰-硬联合麻醉剖宫产产妇寒战的影响[J].吉林医学,2023,44(07):1874-1877.
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