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2023年7月 第38卷 第7期11
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纳米载体药物用于缓解慢性肾脏病纤维化的研究进展

Recent advances in nanomedicines for alleviating chronic kidney disease fibrosis

来源期刊: 广州医药 | 1-10 发布时间:2022-10-11 收稿时间:2025/11/13 18:16:26 阅读量:20
作者:
关键词:
慢性肾脏病纳米药物肾脏递送抗纤维化治疗
chronic kidney diseasenanomedicinesrenal deliveryantifibrotic therapy
DOI:
10.3969/j.issn.1000-8535.2022.05.001
收稿时间:
2022-05-15 
修订日期:
 
接收日期:
 
引用总数:
0  
慢性肾脏病是一类具有高发病率、高死亡率的慢性疾病群。临床上一般采用血液透析和肾脏移植治疗终末期的慢性肾脏病。研究表明,小分子药物或核酸类药物在慢性肾脏病治疗中极具潜力,但是缺乏特异性导致肾脏纤维化治疗效果有限,亟需开发新的治疗策略。纳米载体因具有良好的理化性质,被广泛应用于生物医学领域。本文综述了近年来纳米载体递送小分子或核酸类药物在慢性肾脏病中的研究进展。
Chronic kidney disease (CKD) is a series of chronic disease groups associated with high morbidity and mortality. Hemodialysis and kidney transplantation are the only choices for end-stage renal disease. According to the literature report, it is shown that small molecule and nucleic acid drugs have great potential in CKD treatments with an unsatisfied therapeutic efficacy because of the lack of specific targeting. Thus, it is necessary to develop a new strategy. Nanocarriers have been widely used in biomedical fields due to their excellent physical and chemical properties. In this review, we have summarized the recent advances in applying functional nanocarriers to deliver the small molecules and nucleic acid drugs in the treatment of CKD.
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