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2023年7月 第38卷 第7期11
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IPF、H-IPF在血流感染中的应用价值

Application value of IPF and H-IPF in bloodstream infection

来源期刊: 广州医药 | 36-41 发布时间:2022-11-30 收稿时间:2025/11/13 18:14:20 阅读量:91
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关键词:
IPF指标H-IPF指标血流感染诊断价值
IPFH-IPFbloodstream infectiondiagnostic value
DOI:
10.3969/j.issn.1000-8535.2022.06.008
收稿时间:
2021-11-22 
修订日期:
 
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引用总数:
1  
目的 研究未成熟血小板分数(IPF)、高荧光未成熟血小板比例(H-IPF)指标在血流感染中的早期诊断价值。方法 选取2020年7月—2021年1月广州市第一人民医院的血培养阳性患者100例作为主要的研究对象,重症病人对照50例,健康对照50例。收集各组患者IPF、H-IPF、大型血小板比率(P-LCR)、血小板体积分布宽度(PDW)、粒/淋、粒/单指标的数值,采用单因素方差分析、构建ROC曲线的方法分析比较各组的IPF、H-IPF、P-LCR、PDW、粒/淋、粒/单比值的差异及其与血流感染效能的关系。结果 IPF、H-IPF、粒/淋、粒/单比值在血流感染组高于其他2组,差异有统计学意义(χ2分别是15.190,10.250,39.490,12.850;P<0.05),而 P-LCR、PDW在3组之间无统计学意义。其中,IPF与H-IPF对血流感染诊断效能较高,其中IPF的AUC为0.855(95% CI为0.737~0.973),H-IPF的AUC为0.845(95% CI为0.722~0.968)。结论 IPF、H-IPF与血流感染密切相关,这2个指标对血流感染患者具有一定的诊断价值。
Objective To explore the early diagnosis value of immature platelet fraction (IPF) and high fluorescent immature platelet fraction (H-IPF) in bloodstream infection.Methods A total of 100 patients with positive blood culture result from July 2020 to January 2021 in Guangzhou First People's Hospital were selected as the research objects,in the mean while,50 critically ill patients and 50 healthy patients were enrolled as two control groups.The values of IPF,H-IPF,platelet-large cell rate (P-LCR),platelet distribution width (PDW),neutrophils/lymphocytes,neutrophils/monocyte ratio of patients in each group were collected,and one-way analysis of variance and ROC curve were used to compare the data,to further analyze their relationship with the bloodstream infection.Results The IPF,H-IPF,neutrophils/lymphocytes,neutrophils/monocyte ratio in the bloodstream infection group were significantly higher than control groups,with statistical significance (χ2=15.190,10.250,39.490,12.850; P<0.05),while P-LCR and PDW had no statistical significance.Among them,IPF and H-IPF were highly effective in diagnosing bloodstream infection,the AUC of IPF was 0.855 (95% CI: 0.737-0.973) and the AUC of H-IPF was 0.845 (95% CI: 0.722-0.968).Conclusions IPF and H-IPF were closely related to bloodstream infection,and these two indicators had a certain value in diagnosing patients with bloodstream infection.
1、 余潇,胡海珍,李小宁.降钙素原、血小板计数联合检测对血流感染的诊断价值[J].检验医学与临床,2019,16(19):2779-2781,2786. 余潇,胡海珍,李小宁.降钙素原、血小板计数联合检测对血流感染的诊断价值[J].检验医学与临床,2019,16(19):2779-2781,2786.
2、 PARK S H,HA S O,CHO Y U,et al.Immature platelet fraction in septic patients: clinical relevance of immature platelet fraction is limited to the sensitive and accurate discrimination of septic patients from non-septic patients,not to the discrimination of sepsis severity[J].Ann Lab Med,2016,36(1):1-8. PARK S H,HA S O,CHO Y U,et al.Immature platelet fraction in septic patients: clinical relevance of immature platelet fraction is limited to the sensitive and accurate discrimination of septic patients from non-septic patients,not to the discrimination of sepsis severity[J].Ann Lab Med,2016,36(1):1-8.
3、 王瑞雪.血小板各参数对早期脓毒症预后的预测价值[D].沈阳:中国医科大学,2020. 王瑞雪.血小板各参数对早期脓毒症预后的预测价值[D].沈阳:中国医科大学,2020.
4、 van de WYNGAERT Z,FOURNIER E,BERA E,et al.Immature platelet fraction(IPF):A reliable tool to predict peripheral thrombocytopenia[J].Curr Res Transl Med,2020,68(1):37-42. van de WYNGAERT Z,FOURNIER E,BERA E,et al.Immature platelet fraction(IPF):A reliable tool to predict peripheral thrombocytopenia[J].Curr Res Transl Med,2020,68(1):37-42.
5、 PONS I,MONTEAGUDO M,LUCCHETTI G,et al.Correlation between immature platelet fraction and reticulated platelets.Usefulness in the etiology diagnosis of thrombocytopenia[J].Eur J Haematol,2010,85(2):158-163. PONS I,MONTEAGUDO M,LUCCHETTI G,et al.Correlation between immature platelet fraction and reticulated platelets.Usefulness in the etiology diagnosis of thrombocytopenia[J].Eur J Haematol,2010,85(2):158-163.
6、 童欣欣,杨惠宽,罗淑兰,等.未成熟血小板分数推荐值测定及其在败血症中的应用研究[J].热带医学杂志,2020,20(6):820-824,828. 童欣欣,杨惠宽,罗淑兰,等.未成熟血小板分数推荐值测定及其在败血症中的应用研究[J].热带医学杂志,2020,20(6):820-824,828.
7、 REEVES H M,MAITTA R W.Immature platelet dynamics in immune-mediated thrombocytopenic states[J].Front Med (Lausanne),2020 (7):597734. REEVES H M,MAITTA R W.Immature platelet dynamics in immune-mediated thrombocytopenic states[J].Front Med (Lausanne),2020 (7):597734.
8、 KOYAMA K,KATAYAMA S,MURONOI T,et al.Time course of immature platelet count and its relation to thrombocytopenia and mortality in patients with sepsis[J].PLoS One,2018,13(1):e0192064. KOYAMA K,KATAYAMA S,MURONOI T,et al.Time course of immature platelet count and its relation to thrombocytopenia and mortality in patients with sepsis[J].PLoS One,2018,13(1):e0192064.
9、 MC FADYEN J D,KAPLAN Z S.Platelets are not just for clots[J].Transfus Med Rev,2015,29(2): 110-119. MC FADYEN J D,KAPLAN Z S.Platelets are not just for clots[J].Transfus Med Rev,2015,29(2): 110-119.
10、 MC DONNELL A,BRIDE K L,LIM D,et al.Utility of the immature platelet fraction in pediatric immune thrombocytopenia: Differentiating from bone marrow failure and predicting bleeding risk[J].Pediatr Blood Cancer,2018,65(2). MC DONNELL A,BRIDE K L,LIM D,et al.Utility of the immature platelet fraction in pediatric immune thrombocytopenia: Differentiating from bone marrow failure and predicting bleeding risk[J].Pediatr Blood Cancer,2018,65(2).
11、 卢秋维,廖美娟,林雪珍.5种炎性指标对革兰阴性菌和革兰阳性菌所致脓毒症的早期诊断及鉴别诊断价值比较[J].山东医药,2019,59(17):79-82. 卢秋维,廖美娟,林雪珍.5种炎性指标对革兰阴性菌和革兰阳性菌所致脓毒症的早期诊断及鉴别诊断价值比较[J].山东医药,2019,59(17):79-82.
12、 王刚.血小板参数变化与细菌感染的相关性研究[D].广州:南方医科大学,2020. 王刚.血小板参数变化与细菌感染的相关性研究[D].广州:南方医科大学,2020.
13、 任飞.血培养阳性患者的细菌分布及耐药性分析[D].银川:宁夏医科大学,2016. 任飞.血培养阳性患者的细菌分布及耐药性分析[D].银川:宁夏医科大学,2016.
14、 张丹,郑锐.前言——关注老年血流感染诊治进展[J].实用老年学,2019,33(3):209-210. 张丹,郑锐.前言——关注老年血流感染诊治进展[J].实用老年学,2019,33(3):209-210.
15、 de BLASI R A,CARDELLI P,COSTANTE A,et al.Immature platelet fraction in predicting sepsis in critically ill patients[J].Intensive Care Med,2013,39(4):636-643. de BLASI R A,CARDELLI P,COSTANTE A,et al.Immature platelet fraction in predicting sepsis in critically ill patients[J].Intensive Care Med,2013,39(4):636-643.
16、 王淼,曹书华,王勇强,等.未成熟血小板比率与脓毒症严重程度的相关性研究[J].中华急诊医学杂志,2018,27(7):790-793. 王淼,曹书华,王勇强,等.未成熟血小板比率与脓毒症严重程度的相关性研究[J].中华急诊医学杂志,2018,27(7):790-793.
17、 NOWILL A E,FORNAZIN M C,SPAGO M C,et al.Immune response resetting in ongoing sepsis[J].J Immunol,2019,203(5):1298-1312. NOWILL A E,FORNAZIN M C,SPAGO M C,et al.Immune response resetting in ongoing sepsis[J].J Immunol,2019,203(5):1298-1312.
18、 张艳,华川.血流感染诊断的研究进展[J].国际检验医学杂志,2011,32(14):1594-1596. 张艳,华川.血流感染诊断的研究进展[J].国际检验医学杂志,2011,32(14):1594-1596.
19、 CECCONI M,EVANS L,LEVY M,et al. Sepsis and septic shock[J].Lancet,2018,392(1014):75-87. CECCONI M,EVANS L,LEVY M,et al. Sepsis and septic shock[J].Lancet,2018,392(1014):75-87.
20、 蒋杰,李鑫,何发明,等.淋巴细胞减少在脓毒症患者预后评估中的应用价值[J].当代医学,2019,25(13):7-10. 蒋杰,李鑫,何发明,等.淋巴细胞减少在脓毒症患者预后评估中的应用价值[J].当代医学,2019,25(13):7-10.
21、 李国华.降钙素原与血培养在诊断血流感染中的方法学比较研究[D].太原:山西医科大学,2015. 李国华.降钙素原与血培养在诊断血流感染中的方法学比较研究[D].太原:山西医科大学,2015.
1、蒋馨悦,徐婷.血流感染患者血小板参数动态变化及其预后价值[J].广州医药,2024,55(09):1066-1071. 蒋馨悦,徐婷.血流感染患者血小板参数动态变化及其预后价值[J].广州医药,2024,55(09):1066-1071.
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