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2023年7月 第38卷 第7期11
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131I联合甘氨双唑钠治疗分化型甲状腺癌骨转移的临床疗效

Clinical effect of the combination of 131I and sodium glycididazole in the treatment of differentiated thyroid cancer with bone metastasis

来源期刊: 广州医药 | 70-72 发布时间:2021-11-25 收稿时间:2025/11/13 18:12:08 阅读量:34
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131 I甘氨双唑钠分化型甲状腺癌骨转移
131 ISodium glycididazoleDifferentiated thyroid cancerBone metastases
DOI:
10.3969/j.issn.1000-8535.2021.02.016
收稿时间:
2020-11-25 
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目的 探讨131I联合甘氨双唑钠治疗分化型甲状腺癌(differentiated thyroid carcinoma,DTC)骨转移的临床疗效。方法 以我院96例DTC骨转移患者为研究对象,随机分为对照组和观察组各48例,对照组仅予131I治疗,观察组予131I联合甘氨双唑钠治疗,比较两组的临床疗效、转移灶清除效果及不良反应。结果 根据骨痛评价标准,观察组的有效率(71.00%)高于对照组(48.00%)(P<0.05)。根据血清甲状腺球蛋白(thyroglobulin,Tg)评价标准,观察组的有效率(77.00%)高于对照组(58.00%)(P<0.05)。根据病灶影像学评价标准,观察组的有效率(48.00%)高于对照组(27.00%)(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论 131I联合甘氨双唑钠可提高DTC骨转移患者临床疗效,具有临床推广意义。
Objective To explore the clinical effect of 131I combined with sodium glycididazole in the treatment of differentiated thyroid cancer (DTC) with bone metastasis. Methods Ninty-six patients with DTC bone metastasis were randomly divided into the control group and the observation group, forty-eight patients in each group. The control group was treated with 131I only, while the observation group was treated with 131I combined with glycididazole sodium. The clinical effect, metastasis clearance effect and adverse reactions of the two groups were compared. Results The effective rate of the observation group (71.00%) was higher than that of the control group (48.00%) (P<0.05) according to the evaluation criteria of bone pain. The effective rate of the observation group (77.00%) was higher than that of the control group (58.00%) (P<0.05) according to the evaluation criteria of serum thyroglobulin (Tg). The effective rate of the observation group (48.00%) was higher than that of the control group (27.00%) (P<0.05) according to the imaging evaluation criteria. There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The combination of 131I and sodium glycidazole can improve the clinical effect of patients with DTC bone metastasis, which has clinical significance for promotion.
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