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直接经皮冠状动脉介入治疗急性ST段抬高型心肌梗死患者的性别差异

Sex difference in acute ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention

来源期刊: 广州医药 | 71-76 发布时间:2021-11-23 收稿时间:2025/11/13 18:05:35 阅读量:26
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急性ST段抬高型心肌梗死直接PCI性别差异总缺血时间
Acute ST-segment elevation myocardial infarctionPrimary PCISex differenceTotal ischemic time
DOI:
10.3969/j.issn.1000-8535.2021.04.016
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目的 分析广州北部区域某胸痛中心不同性别的急性ST段抬高型心肌梗死患者直接经皮冠状动脉介入治疗的结果。方法 纳入广州市花都区人民医院2016年12月—2020年1月期间接受直接经皮冠状动脉介入治疗的急性ST段抬高型心肌梗死患者。按照不同的性别,评估患者的危险因素、治疗时限性和主要心血管不良事件情况。结果 入选389名患者,73名(18.8%)为女性。和男性患者对比,女性患者年龄更大(69.3±10.8岁vs 55.8±13.1 岁,P<0.05),具有更高比例的2型糖尿病(26.0% vs 17.7%,P<0.05)、高血压病(58.9.0% vs 43.0%,P<0.05)病史。女性患者的症状-首次医疗接触时间和总缺血时间均长于男性患者(分别为229.2 min vs 174.5 min,P<0.05;424.9 min vs 317.4 min,P<0.05),PCI术中出现慢血流/无复流的比例更高(26.0% vs 16.5%,P<0.05)。女性患者主要住院心血管事件风险更高(11.0% vs 4.4%, P<0.05),其中院内死亡率(4.1% vs 1.6%, P<0.05)。女性患者在院期间发生心衰及心源性休克的比例更高(分别为34.2% vs 21.2%,P<0.05; 30.1% vs 18.7%,P<0.05)。结论 在行急诊介入治疗的急性ST段抬高型心肌梗死患者中,女性患者预后差于男性,具有更高的心血管事件风险,死亡率更高。
Objective We investigated sex-based outcomes after primary percutaneous coronary intervention (PPCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) in a chest pain center of northern Guangzhou. Methods From December 2016 to January 2020, consecutive STEMI patients who underwent PPCI in Guangzhou Huadu District People's Hospital were recruited. Risk factors, time variables, and major cardiovascular adverse events (MACE) were assessed according to gender. Results A total of 389 patients were enrolled,with 73(18.8%)women. Compared to men, women patients presented higher risk profiles with old age(69.3±10.8 years vs 55.8±13.1 years,P<0.05),diabetes (26.0% vs 17.7%,P<0.05), hypertension (58.9.0% vs 43.0%,P<0.05).Women had longer symptom onset to first medical contact time and total ischemic time than men had(229.2min vs 174.5min,P<0.05;424.9min vs 317.4min,P<0.05).During PCI procedure,women presented higher ratio of slow flow/no reflow(26.0% vs 16.5%,P<0.05).Women had increased major adverse events(11.0% vs 4.4%, P<0.05), and higher in-hospital mortality(4.1% vs 1.6%, P<0.05).Women presented more heart failure incidence (34.2% vs 21.2%,P<0.05),and cardiac shock incidence(30.1% vs 18.7%,P<0.05). Conclusion Women with acute STEMI who underwent PPCI had worse outcomes compared to men.They had higher MACE and in-hospital mortality.
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