灵芝孢子粉对中重度慢性阻塞性肺疾病的随访研究

来源期刊：广州医药 | 15-20 发布时间：2021-11-28 收稿时间：2025/11/13 17:52:14 阅读量：20

作者：: 冼慧仪,

冯曙平,

陈艳,

吴凡,

李风雷,

关键词：: 灵芝孢子粉 COPD 肺功能 CD4+CD8+; Ganoderma lucidum spore powder COPD Pulmonary function CD4+CD8+

DOI：: 10.3969/j.issn.1000-8535.2020.02.004

收稿时间：: 2019-09-26
修订日期：
接收日期：
引用总数：: 0

目的观察灵芝孢子粉对中重度慢性阻塞性肺疾病(COPD)稳定期患者肺功能、6分钟步行距离及T淋巴细胞亚群的影响。方法选取稳定期中重度COPD门诊患者19例,服用灵芝孢子粉6个月后观察患者服药前后肺功能的变化及循环血液中CD4⁺、CD8⁺T淋巴细胞的比例变化,症状评分(CAT评分)以及对6 MWT的影响。结果服用灵芝孢子粉6个月后,中重度COPD患者的六分钟步行距离延长,平均增加19 m(P＜0.01),患者的CAT评分也有改善(P＜0.01),患者肺功能与服药前相比有改善趋势,其中FEV₁较服用前平均增加60 mL(P>0.05),FVC平均增加为130 mL(P<0.01),FEV₁/FVC比例降低0.47(P>0.05);外周血CD4⁺T淋巴细胞比例增加(P<0.01),CD8⁺和CD4⁺/CD8⁺T淋巴细胞亚群比例未见明显变化(P＞0.05)。结论服用灵芝孢子粉6个月后对肺功能无明显作用,但能改善中重度COPD患者的CAT症状评分,可能与升高CD4⁺T淋巴细胞比例有关。

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