脾脏炎性假瘤样滤泡树突细胞肉瘤的临床病理分析

来源期刊：广州医药 | 62-65 发布时间：2021-11-28 收稿时间：2025/11/13 17:40:45 阅读量：28

作者：: 唐昭亮,

王康玮,

王小拍,

杜洪,

关键词：: 炎性假瘤样滤泡树突状细胞肉瘤脾脏 EBER 原位杂交; Inflammatory pseudotumor-like follicular dendritic cell sarcoma Spleen EBER EBV-encoded RNA In situ hybridization

DOI：: 10.3969/j.issn.1000-8535.2020.05.014

收稿时间：: 2020-03-01
修订日期：
接收日期：
引用总数：: 0

目的探讨脾脏炎性假瘤样滤泡树突细胞肉瘤( IPT-like FDCS )的临床病理学特征、诊断及其鉴别诊断。方法对2例脾脏 IPT-like FDCS 病例进行临床、组织病理学、免疫组织化学及原位杂交特征的观察及总结,并复习国内外相关文献。结果 2例患者均以腹部不适入院,平均年龄66岁,影像学检查提示脾脏占位;镜下特点:肿瘤由圆形、卵圆形及梭形细胞组成,呈编织状、束状或席纹状排列,背景中见多量淋巴细胞、浆细胞及少许中性粒细胞混杂并伴灶性出血、坏死;免疫组化结果:肿瘤细胞不同程度地表达CD21、CD23滤泡树突细胞标记物,两例均不表达CD35,EBER(EBV-encoded RNA)原位杂交显示瘤细胞散在阳性。结论脾脏IPT-like FDCS 是一种好发于老年女性的罕见的低度恶性肿瘤,与EB病毒感染有关,其生物学行为相对惰性,手术完整切除肿瘤是最佳治疗方式,合理选用免疫标记物、原位杂交检测结合组织病理学可帮助正确诊断。

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