连续捐献机采血小板献血者外周血细胞计数变化情况研究

来源期刊：广州医药 | 27-32 发布时间：2021-11-28 收稿时间：2025/11/13 17:40:26 阅读量：13

作者：: 冯凡凡,

黎世杰,

陈锦艳,

谢桂芸,

邓学成,

吴蕾,

邓阳凡,

汪传喜,

关键词：: 机采血小板外周血血细胞计数外周血血细胞计数变化值; Platelet collection Peripheral blood cell count Peripheral blood cell count change

DOI：: 10.3969/j.issn.1000-8535.2020.05.006

收稿时间：: 2020-01-16
修订日期：
接收日期：
引用总数：: 0

目的探索连续捐献机采血小板献血者血小板、白细胞和红细胞计数变化情况。方法以2016年1月1日—2018年9月30日年期间首次献血且连续血小板捐献量在10 U及以上的849人为研究对象进行回顾性研究,采用同一群体的配对t检验来评估第一次与最后一次血小板、红细胞及白细胞计数的变化情况。将采用有序多分类Logistic回归分析调查期间的血小板捐献量对献血者外周血细胞计数的影响。结果配对t检验表明,外周血PLt有增加趋势(t=-8.58,P<0.001);白细胞总体来说有减少趋势(t=5.348,P<0.001);红细胞无改变趋势(t=0.515,P=0.607);有序多分类Logistic回归分析结果显示:PLt的变化值与献血者年龄、性别以及第一次与最后一次献血的间隔期无关系,P＞0.05;但是与血小板捐献量41 U及以上比起来,血小板捐献量在≤30 U的献血者,血小板计数增加的可能性相对较少(血小板捐献量为10～20 U,χ²=13.737,P<0.001;血小板捐献量为21～30 U,χ²=7.491,P=0.006);WBC的变化值与献血者年龄、性别及献血间隔期无关,P＞0.05,但是与血小板捐献量41 U及以上比起来,血小板捐献量在10～20 U的献血者,白细胞计数增加的可能性相对较大,(OR=1.720,95%CI=1.136~2.605,P=0.010) RBC的变化值与献血者年龄、性别无关(P＞0.05);第一次与最后一次献血间隔期越长,红细胞计数增加的可能性就越大,(OR=1.005,95%CI=1.000~1.009,P=0.030);但是与血小板捐献量并无关系。结论血小板捐献间隔期不少于2周间隔期的连续血小板献血者,其外周血PLt和RBC在一定时间内变化情况会受到血小板捐献量的影响而发生增加和减少的变化,但均在正常范围内波动。

Objective To explore the changes of platelet, white blood cell and red blood cell counts of long-term platelet blood donors. Methods A retrospective study was conducted on 849 platelet blood donors who donated for the first time and continuously donated amounts to 10U plateletor or more from January 1, 2016 to September 30, 2018.The paired t test of the same group was used to evaluate the changes of platelet, red blood cell and white blood cell counts between the first time and the last time donation during the study period. Ordinal multinomial logistic regression was conducted to analyze the effects of platelet donation on the peripheral blood cell count of the donor during the survey. Results Paired t-test result showed that there was a increase in PLt (t=-8.58, P<0.000 1);a decrease in WBC(t=5.348, P<0.000 1); and no significant change in RBC (t=0.515, P=0.607).The results of ordinal multinomial logistic regression analysis showed that the change in PLt had no relationship with age, sex, and interval between the first and last blood donation, P>0.05. Compared with donors who donated 41U or above,the possibility of an increase in platelet count was relatively small for those who donated 30U or below(platelet donation amount 10~20U,χ²=13.737,P<0.000 1;platelet donation amount 21～30U,χ²=7.491,P=0.006). There was no relationship between age, gender, and blood donation interval and WBC changes, P>0.05. Compared with donors who donated 41U or above, WBC was more likely to increase for those who donated 10～20 U (OR=1.720, 95%CI=1.136~2.605, P=0.010).RBC changes had nothing to do with age, gender and platelet donation amount of the blood donor, P> 0.05; the longer the interval between the first and last blood donation took, the more likely the red blood cell count increased, (OR=1.005, 95%CI=1.000~1.009, P=0.030). Conclusion For continuous platelet donors with platelet donation intervals of no less than 2 weeks, platelet donation amount will affect the peripheral blood counts,and all the blood conuts are within the normal range.

1、任素玲, 袁秀珍, 沈倩, 等. 外周血细胞参数在多次捐献血小板质量及献血者健康中的评价[J]. 中外女性健康研究, 2018(19): 125-126.

2、 THOKALA R P, RADHAKRISHNAN K, ANANDAN A, et al. Recovery of platelet count among apheresis platelet donors[J]. J Clin Diagn Res: JCDR, 2016, 10(12): EC01-EC04.

3、 LAZARUS E F, BROWNINGR J, NORMAN J, et al. Sustained decreases in platelet count associated with multiple, regular plateletpheresis donations[J]. Transfusion, 2001, 41(6): 756-761.

4、谢桂芸, 黎世杰, 梁华钦. 1年20次以上血小板献血者血小板计数波动情况分析[J]. 广东医学, 2019, 40(20): 2912-2916.

5、林绮文, 陈锦艳, 朱晓梅, 等. 相隔两周捐献机采血小板的献血者外周血常规变化[J]. 泰山医学院学报, 2015, 36(7): 807-808.

6、郑翠萍, 陈元振. 间隔期为2周的单采血小板献血者外周血部分参数的观测及变化分析[J]. 中国输血杂志, 2017, 30(6): 635-637.

7、吴次宁, 李书平, 钟涵, 等. 机采血小板献血间隔期变化对献血者血常规的影响[J]. 现代预防医学, 2014, 41(22): 4121-4123.

8、来祝檩, 孔莉娜, 李北. 献血者捐献机采血小板对外周血部分实验室检查指标的影响[J]. 中国医学工程, 2017, 25(3): 4-7.

9、 RICHA E, KRUEGER P, BURGSTALER E A, et al. The effect of double-and triple-apheresis platelet product donation on apheresis donor platelet and white blood cell counts[J]. Transfusion, 2008, 48(7): 1325-1332.

10、「国家标准」GB18467-2011 献血者健康检查要求[EB/OL]. (2018-10-11)[2020-01-06]. https://baijiahao.baidu.com/s?id=1618890122830115311&wfr=spider&for=pc.

11、 ANDREU G, VASSE J, SANDID I, et al. Use of random versus apheresis platelet concentrates[J]. Transfus Clin Biol, 2007, 14(6): 514-521.