您的位置: 首页 > 2018年5月 第49卷 第3期 > 文字全文
2023年7月 第38卷 第7期11
目录

碱性磷酸酶对透析患者血管钙化和骨质疏松评估价值

The evaluation value of alkaline phosphatase in vascular calcification and osteoporosis in dialysis patients

来源期刊: 广州医药 | 10-14 发布时间:2021-12-01 收稿时间:2025/11/13 17:21:32 阅读量:26
作者:
关键词:
维持性透析碱性磷酸酶血管钙化骨密度
Maintenance dialysisAlkaline phosphateVascular calcificationBone mineral density
DOI:
10.3969/j.issn.1000-8535.2018.03.003
收稿时间:
2018-01-16 
修订日期:
 
接收日期:
 
引用总数:
0  
目的 探讨血碱性磷酸酶水平对维持性透析患者血管钙化与骨质疏松的评估价值。方法 纳入我院186例维持性透析患者,记录相关临床资料并完善实验室检查,以X线片评价血管钙化情况,双能X线吸收法检查骨密度。对上述资料进行双变量相关分析、ROC曲线分析等统计学处理。结果 血碱性磷酸酶水平与股骨颈骨密度负相关,与腹主动脉钙化评分正相关。腹主动脉钙化评分与骨密度负相关。ALP对骨质疏松及严重腹主动脉钙化诊断的ROC曲线下面积分别为0.777及0.701。结论 碱性磷酸酶是评估透析患者血管钙化骨质疏松的良好指标。
Objective To explore evaluation value of alkaline phosphatase in vascular calcification and osteoporosis in maintenance dialysis patients. Methods 186 patients in maintenance dialysis were enrolled in this study. The related clinical data was recorded. The examination of X-ray (lateral abdomens) was done to estimate vascular calcification in patients. Bone mineral density was measured by dual energy X-ray absorptiometry. The results above were analyzed by bivariate correlation analysis and receiver operator characteristic curve. Results By bivariate correlation analysis,serum alkaline phosphatase level was negatively associated with femoral neck bone mineral density, and was positively associated with abdominal aortas calcification scores. Abdominal aortas calcification scores were negatively associated with femoral neck bone mineral density. ROC curve revealed AUCs were respectively 0.777 and 0.701 for serum alkaline phosphatase level in diagnosis of osteoporosis and severe abdominal aortas calcification. Conclusion Alkaline phosphatase may be a good index to evaluate calcification and osteoporosis in maintenance dialysis patients.
1、 ADRAGAO T, HERBERTH J, MONIER-FAUGERE M C, et al. Low bone volume—a risk factor for coronary calcifications in hemodialysis patients[J]. Clin J Am Soc Nephrol, 2009, 4(2): 450-455. ADRAGAO T, HERBERTH J, MONIER-FAUGERE M C, et al. Low bone volume—a risk factor for coronary calcifications in hemodialysis patients[J]. Clin J Am Soc Nephrol, 2009, 4(2): 450-455.
2、 SUMIDA K, MOLNAR M Z, POTUKUCHI P K, et al. Prognostic significance of pre-end-stage renal disease serum alkaline phosphatase for post-end-stage renal disease mortality in late-stage chronic kidney disease patients transitioning to dialysis[J]. Nephrol Dial Transplant, 2018,33(2):264-273. SUMIDA K, MOLNAR M Z, POTUKUCHI P K, et al. Prognostic significance of pre-end-stage renal disease serum alkaline phosphatase for post-end-stage renal disease mortality in late-stage chronic kidney disease patients transitioning to dialysis[J]. Nephrol Dial Transplant, 2018,33(2):264-273.
3、 MARUYAMA Y, TANIGUCHI M, KAZAMA J J, et al. A higher serum alkaline phosphatase is associated with the incidence of hip fracture and mortality among patients receiving hemodialysis in Japan[J]. Nephrol Dial Transplant, 2014,29(8): 1532-1538. MARUYAMA Y, TANIGUCHI M, KAZAMA J J, et al. A higher serum alkaline phosphatase is associated with the incidence of hip fracture and mortality among patients receiving hemodialysis in Japan[J]. Nephrol Dial Transplant, 2014,29(8): 1532-1538.
4、 OWEN T A, ARONOW M, SHALHOUB V,et al. Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix[J]. J Cell Physiol, 1990,143(3): 420-430. OWEN T A, ARONOW M, SHALHOUB V,et al. Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix[J]. J Cell Physiol, 1990,143(3): 420-430.
5、 KAUPPILA L I, POLAK J F, CUPPLES L A, et al.New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study[J]. Atherosclerosis, 1997, 132(2): 245-250. KAUPPILA L I, POLAK J F, CUPPLES L A, et al.New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study[J]. Atherosclerosis, 1997, 132(2): 245-250.
6、 ZHU D,MACKENZIE N C W,SHANAHAN C M, et al. BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway[J]. J Cell Mol Med, 2015,19(1): 165-174. ZHU D,MACKENZIE N C W,SHANAHAN C M, et al. BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway[J]. J Cell Mol Med, 2015,19(1): 165-174.
7、 CHEN L, JIANG W, HUANG J, et al. Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation[J]. J Bone Miner Res, 2010, 25(11): 2447-2459. CHEN L, JIANG W, HUANG J, et al. Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation[J]. J Bone Miner Res, 2010, 25(11): 2447-2459.
8、 TYSON K L, REYNOLDS J L, MCNAIR R, et al. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification[J]. Arterioscler Thromb Vasc Biol, 2003,23(3):489-494. TYSON K L, REYNOLDS J L, MCNAIR R, et al. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification[J]. Arterioscler Thromb Vasc Biol, 2003,23(3):489-494.
上一篇
下一篇
出版者信息








《广州医药》公众号
目录