系统性红斑狼疮患者血清维生素D和白介素-17水平变化及其临床意义

来源期刊：广州医药 | 12-16 发布时间：2021-12-01 收稿时间：2025/11/13 17:11:53 阅读量：25

作者：: 唐莼,

林小军,

余纳,

叶静华,

李伟念,

何志翔,

李芳菲,

蔡小燕,

关键词：: 系统性红斑狼疮 25-羟基维生素D 白介素-17; Systemic lupus erythematosus 25-OH-D Interleukin-17

DOI：: 10.3969/j.issn.1000-8535.2017.03.003

收稿时间：: 2017-01-12
修订日期：
接收日期：
引用总数：: 0

目的探讨系统性红斑狼疮(SLE)患者外周血中25-羟基维生素D(25-OH-D)和白介素-17(IL-17)水平的变化及其临床意义。方法选取40例SLE患者作为研究对象, 20例健康体检人员为健康对照组。运用电化学发光法检测25-OH-D水平,酶联免疫吸附法检测IL-17水平。结果 SLE患者25-OH-D水平明显低于健康对照组(P<0.01),活动期SLE患者25-OH-D水平明显低于缓解期患者(P<0.01)。SLE患者IL-17水平明显升高(P<0.01)。低25-OH-D水平与肾损害(P<0.01)相关,与疾病活动度评分(SLEDAI评分)(r=-0.844,P<0.01)及IL-17水平(r=-0.596,P<0.01)负相关。结论 SLE患者25-OH-D水平降低,低25-OH-D水平与肾损害、病情活动及高IL-17水平相关,25-OH-D可能参与了SLE的炎症进程。

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