耐碳青霉烯肠杆菌科细菌的流行特征研究

来源期刊：广州医药 | 10-13 发布时间：2021-11-30 收稿时间：2025/11/13 17:02:45 阅读量：13

作者：: 杨羚,

杨清清,

陈定强,

关键词：: 碳青霉烯耐药肠杆菌科细菌流行特征分析; Carbapenem resistance Enterobacteriaceae Epidemiological features

DOI：: 10.3969/j.issn.1000-8535.2016.02.004

收稿时间：: 2015-12-09
修订日期：
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引用总数：: 0

目的统计分析2011—2014年我院分离的肠杆菌科细菌数据,探讨耐碳青霉烯肠杆菌科细菌(CRE)的流行特征。方法收集肠杆菌科细菌,根据药敏结果筛选出CRE菌株,并对相关临床资料进行统计分析。结果共分离得到CRE菌株187株,标本来源依次为尿液(32.6%)、痰液(28.9%)和血液(10.7%)。从科室分布来看,39.0%的菌株来自重症监护室病区,23.0%的菌株来自泌尿外科病区,在其它病区呈散发分布。菌株的种属分布方面,肺炎克雷伯菌的比例为39.6%, 大肠埃希菌的比例为20.9%;从病人年龄构成来看,50岁以上高龄患者的分离比例达74.4%。CRE的分离数目随年份的递增而不断升高。结论耐碳青霉烯肠杆菌科细菌的流行率呈现逐年递增的趋势,临床应合理使用相关抗生素,预防和控制CRE在医院环境中的流行。

1、 OTEO J, SAEZ D, BAUTISTA V, et al. Carbapenemase-producing Enterobacteriaceae in Spain in 2012 [J].Antimicrob Agents Chemother, 2013, 57 (12): 6344-6347.

2、 VAN DUIN D, KAYE KS, NEUNER EA, et al. Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes [J].Diagn Microbiol Infect Dis, 2013, 75 (2):115-120.

3、 DORTET L, POIREL L, NORDMANN P. Rapid Detection of ESBL-Producing Enterobacteriaceae in Blood Cultures [J].Emerg Infect Dis, 2015, 21(3): 504-507.

4、 WEIMEI O, LANQING C, YUN L, et al. Epidemiological Characteristics of blaNDM-1 in Enterobacteriaceae and the Acinetobacter calcoaceticus-Acinetobacter baumannii Complex in China from 2011 to 2012 [J].PLoS One, 2014, 9 (12): e113852.

5、 NORDMANN P, NAAS T, POIREL L. Global spread of Carbapenemase-producing Enterobacteriaceae [J].Emerg Infect Dis, 2011, 17 (10):1791-1798.

6、 GARCIA-FERNANDEZ A, VILLA L, CARTA C, et al. Klebsiella pneumoniae ST258 producing KPC-3 identified in italy carries novel plasmids and OmpK36/OmpK35 porin variants [J].Antimicrob Agents Chemother, 2012,56 (4):2143-2145.

7、 LIU Y, WAN LG, DENG Q, et al. First description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing Klebsiella pneumoniae strains in a single Chinese teaching hospital [J].Epidemiol Infect, 2014, 143 (2):376-384.

8、 MARSIK FJ, NAMBIAR S. Review of carbapenemases and AmpC-beta lactamases [J].Pediatr Infect Dis J, 2011, 30 (12):1094-1095.

9、 PAPP-WALLACE KM, ENDIMIANI A, TARACILA MA, et al. Carbapenems: past, present, and future[J].Antimicrob Agents Chemother, 2011, 55(11):4943-4960.

10、 LOGAN LK. Carbapenem-resistant enterobacteriaceae: an emerging problem in children[J].Clin Infect Dis, 2012, 55 (6):852-859.