Objective To investigate the associations between different time and types of intrauterine device with female reproductive tract infection in order to provide evidence for reducing infection rate. Methods 360 females using intrauterine device were continually recruited during Jan 2013-Jan 2015 in our hospital, and their clinical data was also collected in the same period. The associations between reproductive track infection and clinical characteristics including service time, types, age, gravidity and menopause status were further analyzed. Results We found that the female using intrauterine device with tail wire, as well as with non-menopause had higher infection risk than those did not have(P<0.05). In addition, service time of intrauterine device was significantly associated with infection risk in those patients using intrauterine device with tail wire. However, there was no any remarkable relevance for age and gravidity with risk of reproductive track infection. Conclusion The use of intrauterine device with tail wire, as well as longer service time, could cause the increased risk of reproductive track infection for females.