Objective To study and analyze the effect of high quality nursing on curative effect of patients with peptic ulcer and nursing satisfaction. Methods 98 cases of peptic ulcer patients income for treatment from August 2014 to October 2015 were selected as study subjects. The patients were randomly divided into study group and control group, 49 cases in each group. The control group included male 28 case,female 21 case,aged 18～60 years old, average age (43.7±2.1) years, disease duration of(2～10)years, average(5.2±0.4) years.Study group included male 24 cases, female 25 cases, aged 20～59 years old, average age (42.3±3.6) years, disease duration of (2～10) years, average (5.2±0.4) years. After the patient was admitted to hospital, they were treated with digestive ulcer routine treatment (quadruple therapy). On this basis,patients in the control group were given routine nursing care, the study group patients with high quality nursing, compared with the two groups of patients with clinical efficacy and nursing satisfaction. Results Study group patients with peptic ulcer clinical, curative effect was obviously superior to the control group. The study group patients with peptic ulcer, total efficiency was 95.91%, It was 79.59% in the control group, the difference between the data of two groupshad statistical significance (P<0.05). Study group nursing satisfaction was 97.96%, the control group was only81.63%. The study group was significantly higher than the control group, the difference was statistically significant (P<0.05). Quality care may significantly shorten the average length of stay in patients, the difference was statistically significant (P<0.05). Conclusion High quality nursing may significantly shorten the average length of stay in patients with peptic ulcer, improve the curative effect of peptic ulcer patients and nursing satisfaction. It is worthy of clinical popularization and application.