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Bcl-2、COX-2在宫颈癌新辅助化疗前后的表达及临床意义的研究

A study of the expression and clinical significance of the Bcl-2 and COX-2 in cervical cancer before and after neoadjuvant chemotherapy

来源期刊: 广州医药 | 6-9 发布时间:2021-12-02 收稿时间:2025/11/13 16:52:03 阅读量:23
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关键词:
宫颈癌Bcl-2COX-2新辅助化疗
Cervical cancerB-cell lymphoma/leukemia-2(Bcl-2)Cyclooxygenase-2(COX-2)Neoadjuvant chemotherapy(NACT)
DOI:
10.3969/j.issn.1000-8535.2016.06.002
收稿时间:
2016-09-21 
修订日期:
 
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引用总数:
0  
目的 探讨Bcl-2、COX-2在宫颈癌新辅助化疗前后表达的意义, 以及新辅助化疗(NACT)对宫颈癌的近期临床疗效。方法 对32例宫颈癌患者,采集NACT治疗前后的宫颈癌组织标本,采用免疫组织化学SP法检测组织中的Bcl-2及COX-2表达。结果 ①经NACT后,治疗总有效率(CR+PR)为75%,无效率(PD+SD)为25%。②宫颈癌组织中Bcl-2、COX-2的表达均出现明显下降,差异均有统计学意义(P<0.05);临床有效组中Bcl-2、COX-2的表达在NACT后出现显著下降(P<0.05),无效组中Bcl-2、COX-2的表达在NACT前后无明显统计学意义(P>0.05)。结论 Bcl-2、COX-2的表达情况对评价宫颈癌患者新辅助化疗效具有肯定的临床意义,宫颈癌行NACT后近期疗效良好。
Objective To investigate the expression of Bcl-2 and COX-2 in cervical cancer before and after neoadjuvant chemotherapy; To evaluate the efficacy of neoadjuvant chemotherapy(NACT) for cervical cancer in the recent clinical effects. Methods To select 32 cases of patients with cervical cancer, collect the cervical cancer tissues before and after NACT, immunohistochemical SP method was used to detect the expression of Bcl-2and COX-2 in the tissues. Results After neoadjuvant chemotherapy, total effective rate (CR+PR) was 75%(24/32), inefficient rate(PD+SD) was 25%(8/32). The expression of Bcl-2 and COX-2 of cervical cancer patients who had neoadjuvant chemotherapy (NACT), before and after, had great differences. The difference had statistical significance (P<0.05); The expression of Bcl-2 and COX-2 were significantly lower after neoadjuvant chemotherapy in clinical effective group(P<0.05), there is no statistical significance in clinical non-effective group(P>0.05). Conclusion The expression of Bcl-2 and COX-2 of cervical cancer patients has certain clinical significance in evaluating the effect of neoadjuvant chemotherapy in cervical cancer patients. Recent curative effect after NACT in the cervical cancer patients is good.
1、 FERRANDINA G, RANELLETTI FO, LEGGE F, et al. Prognostic role of the ratio between cyclooxygenase-2 in tumor and stroma compartmentsin cervical cancer[J]. Clin Cancer Res, 2004,10(9):3117-3123. FERRANDINA G, RANELLETTI FO, LEGGE F, et al. Prognostic role of the ratio between cyclooxygenase-2 in tumor and stroma compartmentsin cervical cancer[J]. Clin Cancer Res, 2004,10(9):3117-3123.
2、 NAGAI G, KANELLETTI FO, LEGGE F, et al. Cyelooxygenase-2(COX-2) expression in locally advanced cervical cancer patients undergoing chemoradiation plus surgery. Int J Radiat Oncol Biol Phys, 2003,55(l):21-27. NAGAI G, KANELLETTI FO, LEGGE F, et al. Cyelooxygenase-2(COX-2) expression in locally advanced cervical cancer patients undergoing chemoradiation plus surgery. Int J Radiat Oncol Biol Phys, 2003,55(l):21-27.
3、 黄艳,金淑静,柳红,等. P-gp和Bcl-2在大肠癌中的表达及相关性的研究[J]. 广州医药,2004,35(2):6-9. 黄艳,金淑静,柳红,等. P-gp和Bcl-2在大肠癌中的表达及相关性的研究[J]. 广州医药,2004,35(2):6-9.
4、 SZOSTAK M, KAUR P, AMIN P, et al. Apoptosis and bcl-2 expression inprostate cancer significance in clinical outcome after brachytherapy[J]. J Urol, 2001,165(6 Pt 1):2126-2130. SZOSTAK M, KAUR P, AMIN P, et al. Apoptosis and bcl-2 expression inprostate cancer significance in clinical outcome after brachytherapy[J]. J Urol, 2001,165(6 Pt 1):2126-2130.
5、 SCHMITT CA, ROSENTHAL CT, LOWE SW. Genetic analysis of chemoresistance in primary murine lymphomas[J]. Nat Med, 2000,6(9):1029-1035. SCHMITT CA, ROSENTHAL CT, LOWE SW. Genetic analysis of chemoresistance in primary murine lymphomas[J]. Nat Med, 2000,6(9):1029-1035.
6、 张琦,许进琼.环氧合酶-2及核因子-κB在宫颈癌组织中的表达及意义[J]. 现代医药卫生,2009,25(6):2417-2418. 张琦,许进琼.环氧合酶-2及核因子-κB在宫颈癌组织中的表达及意义[J]. 现代医药卫生,2009,25(6):2417-2418.
7、 DEMPKE W, RIE C, et al. Cyclooxygenase-2: a novel target for cancer chemotherapy[J]. Cancer Res Oncol,2001,127(7):411-417. DEMPKE W, RIE C, et al. Cyclooxygenase-2: a novel target for cancer chemotherapy[J]. Cancer Res Oncol,2001,127(7):411-417.
8、 陆俊国,杨磊,谭清和,等.非小细胞肺癌组织COX-2和HER-2表达及其临床意义[J]. 中华肿瘤防治杂志,2010,17(3):206-212. 陆俊国,杨磊,谭清和,等.非小细胞肺癌组织COX-2和HER-2表达及其临床意义[J]. 中华肿瘤防治杂志,2010,17(3):206-212.
9、 刘美兰,李乐云.COX-2和mPGEs-1与肿瘤关系的研究进展[J]. 中华肿瘤防治杂志,2010,17(14):1134-1137. 刘美兰,李乐云.COX-2和mPGEs-1与肿瘤关系的研究进展[J]. 中华肿瘤防治杂志,2010,17(14):1134-1137.
10、 PROTRKA Z, ARSENIJEVIC S, et al. Co-overexpression of bcl-2 and c-myc in uterine cervix carcinomas and premalignant lesions[J]. Eur J Histochem, 2011,55(1):44-49. PROTRKA Z, ARSENIJEVIC S, et al. Co-overexpression of bcl-2 and c-myc in uterine cervix carcinomas and premalignant lesions[J]. Eur J Histochem, 2011,55(1):44-49.
11、 朱华,施铮铮. Survivin、Bcl-2、HPV 16/18 在宫颈上皮内瘤变及 宫颈癌中的表达及临床意义[J]. 实用妇产科杂志,2010,26(1):57-60. 朱华,施铮铮. Survivin、Bcl-2、HPV 16/18 在宫颈上皮内瘤变及 宫颈癌中的表达及临床意义[J]. 实用妇产科杂志,2010,26(1):57-60.
12、 ZHOU XL, WANG M. Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis[J]. Genet Mol Res, 2015,14(4):17059-17067. ZHOU XL, WANG M. Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis[J]. Genet Mol Res, 2015,14(4):17059-17067.
13、 林悦欢,何慧仪.检测Bcl-2、COX-2在宫颈病变诊断中的可行性研究[J]. 中国妇幼保健,2013,28(28):4618-4620. 林悦欢,何慧仪.检测Bcl-2、COX-2在宫颈病变诊断中的可行性研究[J]. 中国妇幼保健,2013,28(28):4618-4620.
14、 林仲秋,王丽娟.国际妇产科联盟2012宫颈癌诊治指南解读[S]. 中国实用妇科与产科杂志,2013,29(5):323-325. 林仲秋,王丽娟.国际妇产科联盟2012宫颈癌诊治指南解读[S]. 中国实用妇科与产科杂志,2013,29(5):323-325.
15、 LEI T, MAO WM, LEI TH, et al. Incidence and mortality trend of cervical cancer in 11 cancer registries of China[J]. Chin J Cancer Res, 2011, 23(1):10-14. LEI T, MAO WM, LEI TH, et al. Incidence and mortality trend of cervical cancer in 11 cancer registries of China[J]. Chin J Cancer Res, 2011, 23(1):10-14.
16、 杨炜敏,袁力,何善阳,等.KAI1 转移抑制基因在宫颈鳞癌中的表达及临床意义[J]. 广州医药,2009,40(4):25-27. 杨炜敏,袁力,何善阳,等.KAI1 转移抑制基因在宫颈鳞癌中的表达及临床意义[J]. 广州医药,2009,40(4):25-27.
17、 谢幸,苟文丽.妇产科学(第8版)[M]. 北京:人民卫生出版社,2013.304. 谢幸,苟文丽.妇产科学(第8版)[M]. 北京:人民卫生出版社,2013.304.
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