Objective To observe the effects of wet compress based early comprehensive intervention therapy in the treatment of infant eczema. Methods 118 cases of infantile eczema within the jurisdiction were randomly divided into observati on group (60 cases)and control group (58 cases). The observation group was given early comprehensive therapy based on wet compress while the control group took general family intervention.Follow-up observations were adopted for both groups to examine the curing of eczema and to collect data for eczema recurrence. Results In the observation group of 60 cases, 38 were cured, accounting for 63.3%; 20 markedly improved (33.3%),2 effective(3.3%) and 0 ineffective; with the total effective rate of 100%.of the 38 cases cured, eczema reappeared in 8 cases after eight weeks of follow-up observation, with the recurrence rate of 21%. In the control group of 58 cases, 20 were cured, accounting for 34.48%; 14markedly improved (24.14%), 16 effective (27.59%),and 8 ineffective (13.79%),with the total effective rate of 86.21%. In the observation group, eczema recurred in 8 of the 38 cured cases after eight weeks of follow-up observation, with the recurrence rate of 21% while in the control group, eczema recurred in 6 cases, with the recurrence rate of 30%. Conclusion Wet compress based early comprehensive intervention therapy can effectively relieve the symptoms of eczema, so it can be effectively used in community treatment of infantile eczema.