目的 对比输尿管硬镜、输尿管软镜钬激光碎石术在输尿管上段结石治疗中的应用价值。方法 分析于我院接受住院手术治疗的80例输尿管上段结石患者基本资料,按照入院顺序对患者进行分组治疗,对照组实施输尿管硬镜钬激光碎石术治疗,研究组实施输尿管软镜钬激光碎石术治疗,对比两组治疗相关数据及并发症发生率。结果 术后研究组患者PCT、CRP、IL-6、IL-10指标均较对照组理想（P<0.05）;术后研究组患者生活质量评分高于对照组（P<0.05）;研究组高热发生率低于对照组（P<0.05）,其他并发症发生率无明显差异（P>0.05）。结论 相比输尿管硬镜,对输尿管上段结石患者实施输尿管软镜钬激光碎石术治疗能够显著改善手术指标和炎性因子指标,有利于提升患者术后生活质量,且安全性良好。

Objective To explore the value of ureteral rigid and ureteral flexible holmium laser lithotripsy in the treatment of upper ureteral stones．Methods The basic data of 80 patients with upper ureteral stones who underwent inpatient surgical treatment in our hospital were analysed,and the patients were divided into equal groups according to the order of admission．The control group was treated with holmium laser lithotripsy by rigid ureteroscopy,and the study group was treated with holmium laser lithotripsy by ureteroscopy,and the treatment-related data and the incidence of complications were compared between the two groups．Results PCT,CRP,IL-6,and IL-10 indices were closer to the standard range in patients in the study group after surgery（P<0.05）;postoperative quality of life scores of the patients in the study group were higher compared with those in the control group（P<0.05）;the incidence of hyperthermia was lower in the study group than in the control group（P<0.05）,and there was no significant difference in the incidence of other complications（P>0.05）．Conclusions Holmium laser lithotripsy with flexible ureteroscopy for patients with upper ureteral stones can significantly improve surgical indexes and inflammatory factor indexes,and is conducive to the improvement of postoperative quality of life and safety,and has the value of popularization．

目的 研究输尿管镜下钬激光碎石术治疗输尿管结石疗效及对氧化应激指标的影响。方法 选取我院2016年3月—2017年4月间收治的输尿管结石患者60例,随机将其分为对照组和观察组,每组各30例。观察组接受输尿管钬激光碎石术治疗,对照组接受传统开放手术治疗。比较两组手术前后白细胞介素-10(IL-10)、C反应蛋白(CRP)、白细胞(WBC)等炎性因子以及皮质醇(Cor)、丙二醛(MDA)、超氧化物歧化酶(SOD)等氧化应激指标水平,同时比较两组碎石情况。结果 观察组手术时间、住院天数低于对照组,结石排净率高于对照组(P<0.05);术后,观察组IL-10、CRP、WBC高于对照组(P<0.05);观察组Cor、MDA低于对照组,而SOD高于对照组(P<0.05)。结论 输尿管镜下钬激光碎石术治疗输尿管结石疗效显著,能够抑制炎性因子,减轻应激反应,促进患者疾病康复,值得临床推广。

Objective To study the effect of ureteroscopic holmium laser lithotripsy in the treatment of ureteral calculi and its effect on oxidative stress. Methods Sixty patients with ureteral calculi admitted to our hospital from March 2016 to April 2017 were randomly divided into control group and observation group, with 30 cases in each group. The observation group received ureteroscopic holmium laser lithotripsy and the control group received conventional open surgery. We compared inflammatory factors such as interleukin-10 (IL-10), C-reactive protein (CRP), and white blood cells (WBC) before and after surgery, as well as cortisol (Cor), malondialdehyde (MDA), and superoxide dismutase (SOD) and other levels of oxidative stress indicators, while comparing the two groups of debris. Results The operation time and hospitalization days in the observation group were lower than those in the control group. The stone removal rate was higher than that in the control group (P<0.05). After operation, the IL-10, CRP and WBC in the observation group were higher than those in the control group (P< 0.05). Cor and MDA in the observation group were lower than the control group, and SOD was higher than the control group (P<0.05). Conclusion Ureteroscopic holmium laser lithotripsy is effective in the treatment of ureteral calculi. It can inhibit inflammatory factors, reduce stress response, and promote the recovery of patients' diseases. It is worthy of clinical promotion.