目的 探讨替罗非班联合丁苯酞应用于进展性脑梗死的疗效与安全性。方法 选取2016年1月—2018年1月广州医科大学附属第三医院神经内科收治的进展性脑梗死患者98例。对照组采用硫酸氢氯吡格雷加阿司匹林（双抗）治疗,观察组采用替罗非班（静脉治疗48 h）联合丁苯酞序贯双抗治疗。结果 替罗非班联合丁苯酞序贯双抗治疗组的神经功能缺损（NIHSS）评分、日常生活能力评定量表（Barthel指数）、改良 Rankin 量表评分优于对照组,血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）与凝血酶时间（TT）水平高于对照组,两组有差异。两组患者药物不良反应发生率无差异。结论 替罗非班联合丁苯酞序贯双抗治疗可明显改善进展性脑梗死的神经功能,为时间窗外的进展性脑梗死提供了治疗方法,疗效显著。

Objective To observe the effect and safety of triofiban combined with butylphthalide in treatment of progressive cerebral infarction. Methods A total of 98 patients with progressive cerebral infarction in the department of neurology from January 2016 to January 2018.The control group was treated with clopidogrel hydrogen sulfate plus aspirin（dual antiplatelet）. The observer group was treated with Tirofiban（48 h intravenous treatment） combined with butylphthalide on the basis of the treatment of the control group. Results The score of National Institutes of Health Stroke、 Barthel Index and mRS in the triofiban combined with butylphthalide group were better than that of the control group. There were statistical differences between the two groups. PT,APTT and TT were higher than that in the control group .There was no significant difference in drug adverse reactions between the two groups. Conclusion Triofiban combined with butylphthalide may improve the neurologic function of progressive cerebral infarction and provide treatment for progressive cerebral infarction outside the time window.

目的 分析丁苯酞软胶囊联合疏血通治疗急性脑梗死的临床效果。方法 随机抽取我院近几年来收治的急性脑梗死患者87例,按照患者治疗方式分为两组,两组患者均予以常规治疗,对照组43例在此基础上以疏血通治疗,治疗组44例患者在此基础上以丁苯酞软胶囊联合疏血通治疗,对比两组患者治疗效果。结果 治疗组临床疗效总有效率较对照组临床疗效总有效率提高18.8%,两组患者治疗后NIHSS评分较治疗前降低,治疗组治疗后NIHSS评分较对照组低,心理健康、社会功能、精神功能及日常能力较对照组相比,P<0.05。两组患者治疗前后未发生肝肾功能异常情况,无出血等不良反应。结论 丁苯酞软胶囊联合疏血通治疗急性脑梗死具有效果,可改善患者神经功能缺损,临床价值确切。