Objective To analyze the problems existing in drug acceptance, inbound and outbound, to improve work efficiency and make it more scientific and refined. Methods The average time of acceptance, inbound, outbound,s tock checking and inbound error rate before and after improvement were compared, PDCA(Plan, Do, Check, Action) cycle model was applied to analyze problems in drug acceptance, inbound,outbound, distribution and stock checking, countermeasures were formed. Data in March and June 2022 was used as comparative indicators to compare the quality improvement effects before and after the implementation of PDCA cycle management. Results After implementing the PDCA cycle management strategy, and improving the process and applying information technology, the average time for drug acceptance, inbound, outbound, stock checking was reduced by 54%, and the error rate of inbound was reduced by 80%, achieving the predetermined goals and significantly improving work efficiency. Conclusions The application of the PDCA cycle management model can effectively improve the efficiency of drug acceptance, inbound and outbound, reduce personnel costs, ensure the timely supply of drugs, and also effectively improve pharmacists’work enthusiasm and team cohesion.