目的 基于Logistic多因素回归分析颈椎病患者发生项韧带钙化的影响因素，以期为临床制定相应干预方案提供参考。 方法 回顾性选取我院2021年5月~2025年5月收治的198例颈椎病患者作为研究对象，根据是否发生项韧带钙化分为发生组（n=115）、未发生组（n=83），比较两组临床资料，将差异有统计学意义的资料纳入logistic多因素回归分析，分析颈椎病患者发生项韧带钙化的影响因素。 结果 两组年龄、合并糖尿病、高枕睡眠、规律体育锻炼、颈椎曲度异常、每日低头时间、血钙、血磷水平比较，差异具有统计学意义（P＜0.05）；经Logistic回归方程分析结果显示，年龄、合并糖尿病、高枕睡眠、规律体育锻炼、颈椎曲度异常、每日低头时间均为颈椎病患者发生项韧带钙化的独立影响因素（P＜0.05）。 结论 颈椎病患者发生项韧带钙化与年龄、合并糖尿病、高枕睡眠、规律体育锻炼、颈椎曲度异常、每日低头时间密切相关，临床可结合其针对性制定相应干预方案，以降低钙化风险、延缓颈椎病进展。

目的 探讨血碱性磷酸酶水平对维持性透析患者血管钙化与骨质疏松的评估价值。方法 纳入我院186例维持性透析患者,记录相关临床资料并完善实验室检查,以X线片评价血管钙化情况,双能X线吸收法检查骨密度。对上述资料进行双变量相关分析、ROC曲线分析等统计学处理。结果 血碱性磷酸酶水平与股骨颈骨密度负相关,与腹主动脉钙化评分正相关。腹主动脉钙化评分与骨密度负相关。ALP对骨质疏松及严重腹主动脉钙化诊断的ROC曲线下面积分别为0.777及0.701。结论 碱性磷酸酶是评估透析患者血管钙化骨质疏松的良好指标。

Objective To explore evaluation value of alkaline phosphatase in vascular calcification and osteoporosis in maintenance dialysis patients. Methods 186 patients in maintenance dialysis were enrolled in this study. The related clinical data was recorded. The examination of X-ray (lateral abdomens) was done to estimate vascular calcification in patients. Bone mineral density was measured by dual energy X-ray absorptiometry. The results above were analyzed by bivariate correlation analysis and receiver operator characteristic curve. Results By bivariate correlation analysis,serum alkaline phosphatase level was negatively associated with femoral neck bone mineral density, and was positively associated with abdominal aortas calcification scores. Abdominal aortas calcification scores were negatively associated with femoral neck bone mineral density. ROC curve revealed AUCs were respectively 0.777 and 0.701 for serum alkaline phosphatase level in diagnosis of osteoporosis and severe abdominal aortas calcification. Conclusion Alkaline phosphatase may be a good index to evaluate calcification and osteoporosis in maintenance dialysis patients.