Objective To analyze the clinical manifestations of brucellosis and the key characteristics in laboratory testing,and systematically summarize the diagnostic process and treatment strategies of brucellosis.Methods The 70 patients with brucellosis diagnosed via rose bengal test(RBT)and standard agglutination test(SAT) were at Yanbian University Affiliated
Hospital from November 2013 to November 2023.This study conducted a retrospective analysis of the epidemiological data,clinical manifestations and routine laboratory pathological examination data of these patients,and the characteristics of clinical changes were summarized.Results Among the 70 patients with brucellosis,84.29% were male,with a median age of 45(IQR 35-58);91.43% patients had a history of cattle/sheep exposure.The acute phase accounted for 92.86%,and the main symptoms were fever(100%),sweating(88.57%),arthragia(84.29%),hepatosplenomegaly(55.71%),and 90% were irregular fever.The misdiagnosis rate was 27.14%,and most of them were misdiagnosed as sepsis or osteoarthritis.Combined treatment with antibiotics(rifampin + doxycycline)was effective.Conclusions The increase in atypical symptoms(such as irregular heat type)leads to a high misdiagnosis rate.Epidemiological history(cattle/sheep contact)is the key to diagnosis.It is necessary to strengthen occupational protection and atypical case identification,standardize treatment and control the source of infection to curb the epidemic.