目的 观察百令胶囊辅助缬沙坦治疗IgA肾病效果及对患者肾功能、细胞免疫调节、尿足细胞标志蛋白的影响。方法 选取2019年5月—2021年5月西部战区总医院肾内科收治经肾活检确诊为IgA肾病,筛选治疗方案中尚未使用激素及免疫抑制剂的80例患者,按住院先后顺序随机分为观察组和对照组,每组各40例。对照组给予缬沙坦治疗,观察组给予百令胶囊辅助缬沙坦治疗,治疗12周后,比较2组的疗效、治疗前后肾功能指标[24 h蛋白尿(24 h Upro)、尿素氮(BUN)、血肌酐(SCr)、尿红细胞(RBC)计数]、1型/2型辅助性T细胞(Th1/Th2)代表细胞因子[γ-干扰素(IFN-γ)、白介素-4(IL-4)]、尿足细胞标志蛋白[尿足萼糖蛋白(PCX)、尿足细胞B7-1分子(B7-1)]水平。结果 治疗12周后,观察组的治疗总有效率为95.0%,高于对照组的82.5%;观察组的24 h Upro、BUN、SCr、尿RBC计数低于对照组,IFN-γ、Th1/Th2低于对照组、IL-4高于对照组,尿PCX、B7-1水平低于对照组;差异均有统计学意义(P<0.05)。结论 百令胶囊辅助缬沙坦治疗IgA肾病患者,可以提高临床疗效,有效保护患者肾功能,调节其免疫状态,减轻肾损伤。

Objective To observe the effects of Bailing capsules assisting valsartan in the treatment of IgA nephropathy and its influence on renal function, cellular immune regulation and urine prodocytes marker protein. Methods From May 2019 to May 2021, 80 patients with IgA nephropathy confirmed by renal biopsy in the Nephrology Department of Western Theatre Command General Hospital, who had not used hormones or immunosuppressants in the treatment were selected.Patients were divided into observation group and control group according to the order of hospitalization, 40 cases in each group.The control group was given valsartan, and the observation group was given Bailing capsules and valsartan.After 12 weeks of treatment, the efficacy, the levels of renal function indexes [24 h proteinuria (24 h Upro), urea nitrogen (BUN), serum creatinine (SCr), urinary red blood cell (RBC) count], type 1/type 2 helper T cells (Th1/Th2) represent cytokines [interferon-γ (IFN-γ), interleukin-4 (IL-4)], urine prodocytes marker protein [urine podocalyxin (PCX), urinary podocyte B7-1 molecule (B7-1)] before and after treatment were compared between the two groups. Results After treatment, the total effective rate in observation group was higher than that in control group (95.0% vs 82.5%).The 24 h Upro, BUN, SCr levels and urine RBC count in observation group were lower than those in control group, IFN-γ and Th1/Th2 levels were lower than those in control group, the IL-4 level was higher than that in control group, and the levels of urine PCX and B7-1 were lower than those in control group.Those differences were statistically significant (P<0.05). Conclusions Bailing capsules assisting valsartan in the treatment of IgA nephropathy can improve clinical efficacy, effectively protect the renal function of patients, regulate the immune status, and alleviate renal injury.

目的 分析慢性肾衰竭患者接受肾衰康方治疗对其血清微炎症状态的影响及肾功能的保护作用。方法 将2020年1月—2020年12月作为研究时间段,选取期间广东祈福医院接诊的50例慢性肾衰竭患者,另将随机数字表法作为分组依据,将全部病例分为对照组(行常规治疗,纳入25例)、观察组(加用肾衰康方治疗,纳入25例),对组间中医症状评分、血清微炎症状态、肾功能指标、氧化应激指标展开分析。结果 组间中医症状评分、血清微炎症状态、肾功能指标、氧化应激指标在治疗前无明显差异,P>0.05;观察组中医症状评分、血清微炎症状态、肾功能指标、氧化应激指标在治疗后优于对照组,P<0.05。结论 肾衰康方对改善慢性肾衰竭患者血清微炎症状态、氧化应激水平、临床症状均有较好效果,且能保护肾功能,值得推广。

Objective To analyze the effect of Shenshuaikang decoction on serum microinflammation and renal function in patients with chronic renal failure. Methods From January 2020 to December 2020, 50 patients with chronic renal failure treated by Clifford Hospital were selected, and the random number table method was used for grouping. All cases were divided into control group (n=25) and observation group (n=25). The TCM symptom score, serum microinflammatory state, renal function index and oxidative stress index were analyzed. Results There were no significant differences in TCM symptom score, serum microinflammatory state, renal function index and oxidative stress index between the two groups before treatment, P>0.05; the TCM symptom score, serum microinflammatory state, renal function index and oxidative stress index of the observation group were better than those of the control group after treatment, P<0.05. Conclusion Shenshuaikang decoction has good effect on improving serum microinflammation, oxidative stress level and clinical symptoms of patients with chronic renal failure, and also can protect renal function, which is worthy of promotion.

目的 了解南昌市某政府机关退休人员的健康状况,为制定有针对性的疾病防治措施提供依据。方法 根据南昌大学医院体检科常规体检项目,于2016—2018年对南昌市某政府机关退休职工进行健康体检,分析体检异常所占比例,采用χ²检验比较两样本率。结果 腹部彩超、甲状腺彩超、血脂、幽门螺杆菌（HP）、心电图、肝肾功能、宫颈刮片与白带（女）、血糖、肿瘤指标等为主要异常指标。2016—2018年的腹部彩超异常率分别高达82.98%、88.64%和82.95%,腹部彩超异常者中前列腺增生、脂肪肝和胆道系统异常所占比例较高。腹部彩超异常比例男性高于女性,甲状腺彩超和肿瘤指标异常比例女性高于男性（P<0.05）。结论 该政府机关退休职工健康体检指标异常所占比例较高,需要建立健康档案数据库进行健康管理,并对体检指标异常者安排定期复检,以实现对疾病的“早发现,早诊断,早治疗”。

Objective To understand the health status of retired people in a government agency in Nanchang city,and to provide evidence for the prevention and treatment of diseases. Methods According to the routine physical examination items of the department of physical examination of Nanchang university hospital,the health examination of retired staffs of a government agency in Nanchang city from 2016 to 2018 was carried out. The proportion of abnormal physical examination was analyzed,and the rate of two samples was compared by χ² test. Results Abdominal ultrasound,thyroid ultrasound,blood lipid,helicobacter pylori （HP）,electrocardiogram,liver and kidney function,cervical scraper and leucorrhea （female）,blood sugar,tumor index were the main abnormal indexes. The abnormal rate of color Doppler ultrasound was as high as 82.98% and 82.95%,respectively. The proportions of benign prostatic hyperplasia,fatty liver and abnormal biliary system were higher in the patients with abnormal abdominal color Doppler ultrasound. The abnormal rate of abdominal color Doppler ultrasound was higher in male than that in female,and the abnormal rate of thyroid ultrasound and tumor index were higher in female than that in male （P< 0.05）. Conclusion The proportions of abnormal health examination indexes of retired staffs in this government agency are relatively high. It is necessary to establish a health record database for health management,and arrange periodic reexamination for those who have abnormal physical examination indexes in order to realize importance of early detection and early diagnosis of diseases,and have early treatment.