慢性肾衰竭（CRF）核心病机为脾肾两虚、湿浊瘀毒互结，形成“精亏-络损-浊毒”的恶性循环。文章基于“肾藏精泄浊”理论，系统阐释固肾泄浊法论治CRF的理论依据及临床实践经验。固肾泄浊法以“固肾培本，分消浊毒”为纲，通过填精固摄恢复脾肾气化枢纽，通络活血改善肾络瘀阻，并分消三焦湿浊、瘀浊、毒浊，打破“精微漏泄－浊毒蓄积—络脉损伤”病理过程。唐阁主任基于此创立固肾泄浊方，临床观察表明该方治疗CRF患者疗效确切。固肾泄浊方组方注重脾肾互根、寒温相济、升降相因，动态调整固肾与泄浊权重，契合CRF不同分期病机演变。固肾泄浊法融合藏象学说、络病理论及三焦气化论，以“补泻兼施、藏泄并调”实现标本同治，为CRF中医药治疗提供新思路。

       The core pathological mechanism of chronic renal failure（CRF）involves deficiency of the spleen and kidney，intertwined with dampness，turbidity，blood stasis and toxins，forming a vicious cycle of “essence deficiency-collateral damage-turbid toxin accumulation” Based on the theory of “The kidney stores essence and reduces turbidity”，this article systematically elucidates the theoretical foundation and clinical application of  reinforcing the kidney and  reducing turbidity method for treating CRF．This method，guided by the principles of “securing the kidney to strengthen the root，and resolving turbid toxins”，aims to replenish essence and consolidate the kidney to restore the pivotal qi transformation functions of the spleen and kidney，to unblock collaterals and circulate blood to ameliorate renal collateral stasis，to resolve damp-turbidity，stasis-turbidity，and toxin-turbidity from the Sanjiao．This strategy breaks the pathological progression of “leakage of essence-accumulation of turbid toxins-damage to collaterals”．Professor Tang Ge formulate this Reinforcing the Kidney and Reducing Turbidity Formula（固肾泄浊方，Gushen Xiezhuo Fang）based on this approach．Clinical observations confirmed its significant efficacy in CRF patients．The formula focuses on the interdependence of the spleen and kidney，balance of warm and cool properties，and harmony of ascending and descending actions．It dynamically adjusts the therapeutic focus between kidney-securing and turbidity-reducing to align with the evolving pathogenesis across different CRF stages．Integrating theories of visceral manifestation（Zangxiang），collateral disease，and Sanjiao qi transformation，reinforcing the kidney and  reducing turbidity method achieves simultaneous treatment of  root and branch through “simultaneous supplementation and drainage，concurrent storing and discharging”．This approach offers a novel perspective for the traditional Chinese medicine treatment of CRF．