目的 探讨血浆凝血酶原时间(prothrombin time,PT)和血清蛋白(albumin,Alb)检测在腹内高压(IAH)患者中的临床意义。方法 选取IAH患者30例,另取30例健康者作为对照组,分别检测检验指标PT和ALB。PT检测应用凝固酶法,Alb检测应用溴甲酚绿法。结果 IAH患者组PT、PTR高于对照组,差异有统计学意义(P＜0.05),患者组PTA、Alb低于对照组,差异有统计学意义(P＜0.05)。结论 IAH可引起凝血功能障碍及蛋白丢失,PT和Alb的检测有助于了解IAH患者的病情。
Objective To detect the significance of plasma prothrombin time(PT)and serum albumin(Alb)in patients with intra-abdominal hypertension(IAH). Methods Selected 30 patients with IAH,another 30 healthy persons as control group,were dectected PT and ALB.Coagulase method was used to dectect PT,bromocresol green method was used to dectect ALB. Results PT and PTR in IAH group were significantly higher than those in control group,the difference was statistically significant(P＜0.05),PTA and ALB in IAH group were significantly lower than those in control group,the difference was statistically significant(P＜0.05). Conclusion IAH may cause coagulation dysfunction and loss of protein,detection of PT and Alb is helpful to the understanding of the disease in patients with IAH.
目的 水解乳清蛋白对炎症性肠病大鼠的抗炎作用及机制。方法 将40只雄性大鼠随机分为实验组和对照组,并建立炎症性肠病动物模型,分别喂食添加了水解乳清蛋白及普通蛋白的饲料,喂养4周后处死大鼠,每周检测体重,血清ALB、TNF-α、IL-2、IL-6等。结果 二组间体重及血清白蛋白无区别(P>0.05),实验组与对照组的TNF-α、IL-2及IL-6无区别(P>0.05),从第二周到第四周,实验组的炎症因子水平低于对照组(P<0.05)。结论 水解乳清蛋白具有抗炎作用,能够减少炎症性肠病大鼠动物模型的炎症因子的释放,并改善其营养状况。
Objective To evaluate the anti-inflammatory effects of whey protein on SD rats model of inflammatory bowel disease. Methods 40 SD rats model of inflammatory bowel disease were established and randomly divided into experimental and control groups equally. Experimental and control groups were fed whey protein and ordinary protein respectively. After 4 weeks, TNF-α, IL-2 and IL-6 were detected. Results There were no significant difference between the two groups of weights and the level of ALB. The level of TNF-α, IL-2 and IL-6 between groups were not significantly different in the first week(P>0.05). However, thelevels of TNF-α, IL-2 and IL-6 in experimental group were significantly lower than those of the control group in the follow weeks. Conclusion The whey protein could reduce the production of inflammatory cytokines.
焦虑症是最常见的精神障碍，区别于生理性焦虑，患者常表现出持续的焦虑状态。越来越多证据表明，抑制性神经元参与生理性焦虑的产生和消退，而这类神经元功能异常与焦虑症的发生密切相关。小清蛋白（PV）神经元是一类主要的抑制性中间神经元，广泛分布于大脑皮质和其他脑区，并且具有独特形态和功能。PV神经元可通过快速放电活动精确控制局部微环路和大脑网络活动，进而调控焦虑发生。文章综述PV神经元如何介导生理性焦虑及其功能异常及如何导致焦虑症的产生，重点介绍了PV神经元的解剖和功能特性，这些特性使它们拥有快速和强力的抑制作用，能够快速调控神经网络活动，和PV神经元以及相关的神经环路调控焦虑发生的环路机制，以及PV神经元调控焦虑发生的分子机制，并展望未来的研究方向，以期为开发新的焦虑症干预策略提供科学依据。
Anxiety disorders，distinct from physiological anxiety，are characterized by a chronic and pervasive state of heightened anxiety and represent the most common mental diseases．Emerging evidence implicates inhibitory neurons in both the generation and extinction of physiological anxiety，with dysfunction in these neurons strongly associated with the pathogenesis of anxiety disorders．Among inhibitory neurons，parvalbumin（PV）-positive interneuron，a key subset with unique morphological and functional characteristics，are widely distributed across the cerebral cortex and various brain regions．These neurons exert rapid，potent inhibitory control over local microcircuits and broader neural networks through their fast-spiking activity，making them integral to the regulation of anxiety-related behaviors．This review highlights three key aspects：the anatomical and functional properties of PV neurons；their role in circuit mechanisms；the molecular pathways by which PV neurons regulate anxiety．By elucidating the role of PV neurons in modulating physiological anxiety and highlighting their dysfunction in anxiety disorders，this review aims to inform future research and foster the development of novel therapeutic interventions for anxiety disorders．
