Objective To explore the application value of intrapartum ultrasound for labor management of pregnant women with gestational diabetes mellitus.Methods A total of 100 primiparous women with gestational diabetes mellitus who gave birth in the Obstetrics and Gynecology Department of Foshan Gaoming District People’s Hospital from January 1, 2022 to December 31, 2023 were selected.After signing the informed consent form, the patients were randomly divided into a control group and a study group with 50 cases in each group according to a ratio of 1∶1, using a random number table method.The control group underwent vaginal digital examination to assess the labor process and delivery method.For the study group, the labor process and delivery mode were determined using transabdominal ultrasound measurement.Blood glucose level,routine blood test results, delivery methods, 24-hour postpartum bleeding volume and incision conditions of two groups of primiparas, as well as the Apgar score of newborns were collected.Results The study group demonstrated a significantly higher vaginal delivery rate than the control group(88.0% vs 72.0%, P<0.05), with fewer vaginal examinations(4.18±0.80 vs 6.82±0.80, P<0.05)and a lower incidence of adverse events(4% vs 16%, P<0.05).Compared to the control group, the study group exhibited higher hemoglobin levels([104.10±5.25]g/L vs [100.30±4.78] g/L, P<0.05), but lower white blood cell counts([11.40±1.49]×109/L vs [12.04±1.66]×109/L, P<0.05)and reduced neutrophil percentages([72.79±4.04]% vs [75.01±5.53]%, P<0.05).Conclusions Intrapartum ultrasound monitoring for assessing labor progression in primiparas with gestational diabetes mellitus reduces infection risks associated with vaginal procedures, increases vaginal delivery rates, effectively decreases maternal infections, enhances maternal satisfaction and comfort during delivery,and improves maternal-neonatal outcomes.