Pre-prescription audit is an important measure to promote clinical rational use of drugs,which is of great significance to the transformation of hospital pharmaceutical care mode.Traditional prescription review for retrospective review has lag and limitations,can not real-time monitoring rational drug use.By contrast,pre-prescription audit can timely and effective intervene problem prescription,simplify the unqualified prescription modification process,improve the efficiency of patients take medicine,and man-machine combination can make more pharmaceutical information intelligent multiple advantages.Advanced audit work in various hospitals presents different forms and development level,exploring the new mode,establishing independent maintenance knowledge base,developing basic principles,perfecting personalized principle,comprehensive check of advanted audit system,can intercept or intervene doctors unreasonable prescription from the source,contribute to normative,improve the prescription or advice reasonable rate,realize pharmaceutical wisdom informatization,auxiliary clinical rational use of drugs.