Objective To explore the effects of proprioceptive neuromuscular facilitation(PNF)and home-based remote rehabilitation on coagulation function and balance function in patients with ischemic stroke.Methods From January 2023 to January 2024, 60 patients with ischemic stroke were selected from our hospital.The patients were divided into two groups according to the treatment plan chosen by themselves.The patients in the observation group received PNF technology combined with home-based remote rehabilitation guidance, while the patients in the control group received routine home-based remote rehabilitation guidance.The curative effect, coagulation function and neurological deficit were recorded.Results After treatment, activated partial thrombin time(APTT)and prothrombin time(PT)were significantly higher, D-dimer(D-D)and fibrinogen(FIB)were significantly lower in the observation group than those before treatment(P<0.05).Compared with the control group, the APTT, PT, D-D and FIB of the observation group were similar, and there was no significant difference between the two groups(P>0.05).After treatment, the Berg Balance Scale score of the observation group was higher than that before treatment, and there was significant difference between the two groups(P<0.05).The Berg Balance Scale score, Fugl-Meyer Assessment score and muscle strength grade of observation group were higher than those of control group(P<0.05).Conclusions PNF combined with home-based remote rehabilitation can be used as an effective method for the treatment of patients with ischemic stroke.The coagulation function, balance, extremity function and muscle strength were significantly improved after combined treatment, which indicated that the combined treatment was especially effective in relieving the patients’ symptoms.