目的：探讨粒细胞集落刺激因子（GCSF）宫腔灌注联合宫腔粘连冷刀分离术治疗薄型子宫内膜的临床效果。方法：选取2023年9月—2025年9月间在桐乡市妇幼保健院妇科因薄型子宫内膜住院并行手术治疗的患者101例，按治疗方式不同，分为对照组（56例）与治疗组（45例）。对照组采用宫腔镜下宫腔粘连冷刀分离术治疗，治疗组采取G-CSF宫腔灌注联合宫腔粘连冷刀分离术的方式治疗。比较两组手术前后的子宫内膜厚度情况、性激素指标水平、子宫动脉血流参数、术后临床妊娠情况。结果：治疗组子宫内膜厚度、子宫内膜厚度改善值、LH、E2、AMH、PSV、EDV、临床妊娠率均高于对照组，RI、PI低于对照组（P＜0.05）。结论：G-CSF宫腔灌注联合宫腔粘连冷刀分离术在治疗薄型子宫内膜中可取得令人满意的效果，能通过改善子宫的血流，促进子宫内膜的生长，而且还可提升性激素水平，对促进术后妊娠率的上升有积极的作用。

目的 探索冻融胚胎移植周期胚胎移植前宫腔灌注胚胎培养上清液对胚胎种植及妊娠结局的影响。方法 纳入我院 2019 年 3 月—2019 年 12 月 共计198个冻 融 胚 胎 移 植 ( frozen-thawed embryo transfer,FET)周期。根据 FET 术前是否予胚胎培养液上清液宫腔灌注操作分成 2 组,灌注组93 个周期,对照组即未灌注组105个周期。灌注组分别于FET术前 4 周和术前 1 天行宫腔灌注胚胎培养上清液,对照组未行胚胎培养上清液宫腔灌注,对比两组患者胚胎着床率、临床妊娠率、流产率。结果 灌注组患者的胚胎着床率高于对照组,差异有统计学意义(P＜0.05)。两组间的临床妊娠率、流产率未见统计学差异(P>0.05)。结论 FET术前宫腔灌注胚胎培养上清液可提高胚胎种植率。

Objective To investigate the potential impact of intrauterine perfusion of embryo culture supernatant before frozen-thawed embryo transfer (FET) on pregnancy outcome. Methods From March to December 2019, a total of 198 FET cycles were enrolled for the present study.Patients were divided into two groups: the study group included 93 cycles, patients in this group received intrauterine perfusion of embryo culture supernatant four weeks and one day before the embryo transfer, respectively; the control group included 105 cycles, and patients in this group did not receive intrauterine perfusion. Rates of implantation, pregnancy, and miscarriage were compared between the two groups. Results The implantation rate in the study group was higher than that in the control group (P<0.05). There were no significant differences in clinical pregnancy rate and abortion rate between the two groups (P>0.05). Conclusion With the performance of intrauterine perfusion of embryo culture supernatant before embryo transfer, the implantation rate may be improved in FET cycles.