目的 分析中枢神经系统孤立性纤维瘤(SFT)11例患者的临床特点、影像学及病理学表现、手术结果。方法 回顾性分析2013年—2021年于广州医科大学附属第二医院神经外科接受手术并经病理检查证实为中枢神经系统SFT的11例患者的临床资料。结果 11例患者主要症状为头晕、头痛或肢体乏力。MRI:病灶主要表现为T1WI等-低信号,T2WI混杂信号或等-稍高信号。病理组织学:镜下表现为疏密不一的梭形肿瘤细胞呈交替排列。免疫组化:肿瘤细胞主要表现为STAT6阳性、CD34阳性等特点。病灶全切除患者预后较好,病灶次全切除或既往有SFT复发病史患者容易再次复发。结论 中枢神经系统SFT患者MRI T2WI信号有助于诊断,但是最终诊断依靠病理学检查。手术切除是首选的治疗方式。

Objective To analyze the clinical features,radiological and pathological manifestations and surgical results of 11 patients with solitary fibrous tumors (SFT) of the central nervous system (CNS). Methods The clinical data of 11 patients with SFT of CNS confirmed by pathological examination in the Neurosurgery Department of the Second Affiliated Hospital of Guangzhou Medical University from 2013 to 2021 were retrospectively analyzed. Results The main symptoms of 11 patients were dizziness,headache or extremity weakness. MRI: the lesions mainly showed iso-low signal on T1WI,mixed signal or iso-slightly high signal on T2WI. Histopathological features: microscopically,there were alternating rows of spindle tumor cells with irregular density. Immunohistochemistry showed that the tumor cells were STAT6 positive,CD34 positive,etc. Patients with total resection of the lesion had a better prognosis. Patients with subtotal resection of the lesion or previous history of SFT relapse were prone to relapse. Conclusions MRI T2WI signals in patients with CNS SFT were helpful for diagnosis,but the final diagnosis depended on pathology. Surgical excision is the preferred treatment.

       目的   初步探讨可注射型载阿霉素水凝胶对胶质瘤的治疗作用。方法   使用透析法检测载阿霉素水凝胶在体外释放药物的情况。构建大鼠皮下C6胶质瘤模型，按不同给药途径分为空白对照组、经静脉注射组、水凝胶组。给药15 h后，经免疫荧光检测阿霉素在肿瘤内部的分布情况。给药7 d后，计算出各组的抑瘤率；并对肿瘤组织进行苏木精-伊红染色。结果   在体外，载阿霉素水凝胶具有缓释药物的性能。在体内，与经静脉给药相比，局部注射载阿霉素水凝胶使瘤内分布更多阿霉素，抑瘤率更高（42% vs 64%），肿瘤细胞坏死更明显。结论   载阿霉素水凝胶可为胶质瘤局部化学治提供新的载体。

      Objective  To investigate the therapeutic effect of injectable doxorubicin-containing hydrogel on glioma．Methods  The release of doxorubicin hydrogel in vitro was detected by dialysis．The subcutaneous C6 glioma model of  rats was constructed and divided into blank control group，intravenous injection group and hydrogel group according to different administration methods．The distribution of doxorubicin in the tumor was detected by immunofluorescence 15 hours after administration．After 7 days of administration，the tumor inhibition rate of each group was calculated．The tumor tissue was stained with hematoxylin eosin．Results  In vitro，doxorubicin-containing hydrogels had sustained drug release properties．In vivo，compared with intravenous administration，local injection of doxorubicin-containing hydrogel resulted in more doxorubicin distribution，higher tumor inhibition rate（42% vs 64%）and more obvious tumor cell necrosis．Conclusions  Doxorubicin-containing hydrogel can provide a new carrier 

for local chemotherapy of glioma．