Objective To explore effective strategies for establishing a lymphoedema specialty nursing team within alliance hospitals based on a regional specialty alliance and assess its impact on patient care outcomes.Methods A regional lymphedema specialty nursing team was established by training 20 healthcare professionals from 7 hospitals(Deyang City People’s Hospital,Guanghan People’s Hospital, Luojiang People’s Hospital, Guanghan Maternal and Child Health Hospital, Deyang Tumor Hospital, Zhongjiang Maternal and Child Health Hospital, and Shifang Maternal and Child Health Hospital)in a regional medical consortium, focusing on lymphedema knowledge and intervention skills.The team’s responsibilities and nursing quality control protocols were standardized.The observation group included data from May to August in 2024(post-intervention period), while the control group comprised data from January to April in 2024(pre-intervention period).Comparisons were made between the two groups regarding healthcare professionals’qualification rate in lymphedema knowledge,inpatients’ lymphedema risk screening rate, implementation rate of preventive measures for high-risk patients, upper extremity function assessment scores(using the Disabilities of the Arm,Shoulder and Hand [DASH] scale)at discharge and 1-month post-discharge, and patient satisfaction.Results After the intervention, healthcare professionals’ lymphedema knowledge scores significantly improved across all domains:basic knowledge(17.36±2.54 vs 11.35±2.29), diagnosis/assessment(25.66±4.34 vs 17.87±3.18), treatment/management(25.08±4.73 vs 18.28±3.85),prevention/rehabilitation(15.36±2.53 vs 10.39±2.24),and total score(85.36±8.52 vs 55.35±7.56)(t=7.859, P<0.001; t=6.475, P<0.001; t=4.986, P<0.001; t=6.578, P<0.001; t=11.782, P<0.001).The observation group demonstrated a higher lymphedema risk screening rate(80.72% vs 61.24%,χ2=31.454,P<0.001).DASH scores in the observation group were significantly lower than the control group at discharge(23.36±8.63 vs 25.32±9.16)and 1-month post-discharge(20.16±7.34 vs 22.25±7.67)(t=2.884, P=0.004; t=3.646, P=0.001).Patient satisfaction scores at discharge were higher in the observation group(83.36±8.63 vs 71.37±10.33, t=16.460, P<0.001).Conclusions The lymphoedema specialty nursing team in alliance hospitals based on a regional specialty alliance effectively facilitates the high-quality nursing resources homogenization in primary hospitals.Within the alliance, it achieves homogenization of lymphoedema prevention and treatment, establishes a training base for specialty talents, and overall enhances lymphoedema prevention and control within the region, thereby improving patient satisfaction with healthcare.