MDSCs调控新生儿免疫应答机制及其临床意义

来源期刊：广州医药 | 457-462 发布时间：2024-06-28 收稿时间：2025/11/17 15:49:09 阅读量：64

作者：: 徐凝,

王丽娜,

刘国成,

刘雨丰,

关键词：: 新生儿髓源性抑制细胞免疫调节; newborn myeloid-derived suppressor cells（MDSCs）immune regulation

DOI：: 10.3969/j.issn.1000-8535.2024.05.002

收稿时间：: 2024-03-15
修订日期：
接收日期：
引用总数：: 0

新生儿期的免疫系统发育阶段对维持新生儿健康至关重要,具有独特的免疫调节机制。近年来,人们越来越关注髓源性抑制细胞（MDSCs）在新生儿免疫调节中的作用。MDSCs是一类免疫抑制功能强大的异质性细胞群体,它们能够通过多种机制调节免疫应答。MDSCs在新生儿中的调节作用对防止过度免疫反应和促进免疫耐受至关重要,有助于预防新生儿期炎症性疾病,并对其后续健康产生积极影响。近期研究文献分析展示了MDSCs在新生儿免疫调节中的多种作用机制,包括在特定病理条件下的保护作用、与新生儿期炎症反应的相互作用,以及对长期免疫发展的潜在影响。因此,深入理解MDSCs在新生儿免疫中的角色,不仅有助于揭示其复杂的调节机制,也为制定新的预防和治疗新生儿炎症性疾病的策略提供了新的思路。

1、 ZHOU D,YAO M,ZHANG L,et al.Adenosine alleviates necrotizing enterocolitis by enhancing the immunosuppressive function of myeloid-derived suppressor cells in newborns[J].J Immunol,2022,209(2):401-411.

2、 SCHWARZ J,RüHLE J,STEPHAN K,et al.HIF-1α targeted deletion in myeloid cells decreases MDSC accumulation and alters microbiome in neonatal mice[J].Eur J Immunol,2023,53(7):e2250144.

3、 KOLAHIAN S,?Z H H,ZHOU B,et al.The emerging role of myeloid-derived suppressor cells in lung diseases[J].Eur Respir J,2016,47(3):967-977.

4、 GERVASSI A,LEJARCEGUI N,DROSS S,et al.Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses[J].PLoS One,2014,9(9):e107816.

5、 K?STLIN N,VOGELMANN M,SPRING B,et al.Granulocytic myeloid-derived suppressor cells from human cord blood modulate T-helper cell response towards an anti-inflammatory phenotype[J].Immunology,2017,152(1):89-101.

6、 PEREGO M,FU S,CAO Y,et al.Mechanisms regulating transitory suppressive activity of neutrophils in newborns:PMNs-MDSCs in newborns[J].J Leukoc Biol,2022,112(5):955-968.

7、 JABLONSKA J,BRANDAU S.PMN-MDSC in newborns:Regulation of the regulators[J].J Leukoc Biol,2022,112(5):949-950.

8、 SHI M,CHEN Z,CHEN M,et al.Continuous activation of polymorphonuclear myeloid-derived suppressor cells during pregnancy is critical for fetal development[J].Cell Mol Immunol,2021,18(7):1692-1707.

9、 ZHANG Y,QU D,SUN J,et al.Human trophoblast cells induced MDSCs from peripheral blood CD14⁺ myelomonocytic cells via elevated levels of CCL2[J].Cell Mol Immunol,2016,13(5):615-627.

10、 ZHAO A M,XU H J,KANG X M,et al.New insights into myeloid-derived suppressor cells and their roles in feto-maternal immune cross-talk[J].J Reprod Immunol,2016(113):35-41.

11、 GANTT S,GERVASSI A,JASPAN H,et al.The role of myeloid-derived suppressor cells in immune ontogeny[J].Front Immunol,2014(5):387.

12、 VEGLIA F,SANSEVIERO E,GABRILOVICH D I.Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity[J].Nat Rev Immunol,2021,21(8):485-498.

13、 PANG B,HU C,LI H,et al.Myeloidderived suppressor cells:Escorts at the maternal-fetal interface[J].Front Immunol,2023(14):1080391.

14、 K?STLIN N,KUGEL H,SPRING B,et al.Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T-cell responses[J].Eur J Immunol,2014,44(9):2582-2591.

15、 DIETZ S,SCHWARZ J,RüHLE J,et al.Extracellular vesicles released by myeloid-derived suppressor cells from pregnant women modulate adaptive immune responses[J].Cell Immunol,2021(361):104276.

16、 K?STLIN-GILLE N,FLAIG L A,GINZEL M,et al.Granulocytic myeloid-derived suppressor cells in breast milk(BM-MDSC)correlate with gestational age and postnatal age and are influenced by infant’s sex[J].Nutrients,2020,12(9):2571.

17、 K?STLIN N,SCHOETENSACK C,SCHWARZ J,et al.Granulocytic myeloid-derived suppressor cells(GR-MDSC)in breast milk(BM);GR-MDSC accumulate in human bm and modulate T-Cell and monocyte function[J].Front Immunol,2018(9):1098.

18、 SCHWARZ J,SCHECKENBACH V,KUGEL H,et al.Granulocytic myeloid-derived suppressor cells(GR-MDSC)accumulate in cord blood of preterm infants and remain elevated during the neonatal period[J].Clin Exp Immunol,2018,191(3):328-337.

19、 LIU Y,PEREGO M,XIAO Q,et al.Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice[J].J Clin Invest,2019,129(10):4261-4275.

20、 HE Y M,LI X,PEREGO M,et al.Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation[J].Nat Med,2018,24(2):224-231.

21、 LEIBER A,SCHWARZ J,K?STLIN N,et al.Neonatal myeloid derived suppressor cells show reduced apoptosis and immunosuppressive activity upon infection with Escherichia coli[J].Eur J Immunol,2017,47(6):1009-1021.

22、 RIEBER N,GILLE C,K?STLIN N,et al.Neutrophilic myeloid-derived suppressor cells in cord blood modulate innate and adaptive immune responses[J].Clin Exp Immunol,2013,174(1):45-52.