Ki-67、MCM2、p16在宫颈鳞状上皮内病变中表达及意义

来源期刊：广州医药 | 82-88 发布时间：2025-02-13 收稿时间：2025/11/13 18:56:13 阅读量：21

作者：: 温俊秀,

张可心,

王琦,

宋慧茹,

倪璐,

宋旭东,

关键词：: 宫颈鳞状上皮内病变 Ki-67 微小染色体维持蛋白2 p16; cervical intraepithelial lesions Ki-67 MCM2 p16

DOI：: 10.20223/j.cnki.1000-8535.2025.01.012

收稿时间：: 2024-02-21
修订日期：
接收日期：
引用总数：: 1

目的探讨Ki-67、微小染色体维持蛋白2（MCM2）、p16在宫颈鳞状上皮内病变中的表达及其临床意义。方法采用免疫组化检测Ki-67、MCM2、p16在宫颈炎症组14例、低级别鳞状上皮内病变（LSIL）组47例、高级别鳞状上皮内病变（HSIL）组49例中的表达情况,以病理结果作为金标准,对结果进行统计分析。结果 HSIL组中Ki-67、MCM2、p16阳性率均高于炎症组和LSIL组（均P<0.017）。HSIL组中Ki-67、MCM2过表达率均显著高于炎症组和LSIL组（均P<0.017）。随着宫颈病变级别增加,Ki-67及MCM2阳性范围从基底层至表层逐渐扩大。MCM2及Ki-67在LSIL组中表达模式多为基底层的非过表达模式,HSIL组多为中层及以上的过表达模式。Spearman相关性分析显示,MCM2和Ki-67在宫颈鳞状上皮内病变中的表达强度之间呈正相关（r=0.801,P<0.05）;p16与MCM2在宫颈鳞状上皮内病变中的表达呈正相关（r=0.559,P<0.05）;p16与Ki-67在宫颈鳞状上皮内病变中的表达呈正相关（r=0.478,P<0.05）。结论 p16阳性提示宫颈高级别鳞状上皮内病变。MCM2与Ki-67在宫颈鳞状上皮内病变中的表达具有较高一致性,MCM2可作为宫颈鳞状上皮内病变新的增殖标志物。

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