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基于生物信息学分析TRIB2与结肠癌预后和免疫浸润相关性

Correlation of TRIB2 expression with prognosis and immune infiltration in colon cancer based on bioinformatics

来源期刊: 广州医药 | 766-774 发布时间:2025-07-23 收稿时间:2025/11/13 18:53:04 阅读量:33
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关键词:
结肠癌TRIB2预后免疫
colon cancerTRIB2prognosisimmunity
DOI:
10.20223/j.cnki.1000-8535.2025.06.006
收稿时间:
2024-04-30 
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引用总数:
0  
目的 探讨TRIB2在结肠癌中的表达水平及与预后及免疫浸润之间的关系。方法 TIMER数据库分析TRIB2在泛癌种中的表达;TCGA、GSE17538下载结肠癌患者RNA-seq数据和临床信息,评估其与临床病理特征的相关性;生存曲线、单因素和多因素Cox分析探讨TRIB2与预后的相关性,并构建列线图;对TRIB2进行差异基因的富集分析;分析TRIB2表达水平与免疫细胞浸润、免疫检查点、肿瘤突变负荷(TMB)以及免疫治疗敏感性之间的相关性。结果 TRIB2在结肠癌组织中高表达(P<0.05);CMS1结肠癌患者TRIB2 mRNA表达水平最高;TRIB2是结肠癌患者的独立预后因素(单因素Cox回归分析:HR=1.397,95%CI:1.100~1.774,P=0.006;多因素Cox回归分析:HR=1.502,95%CI:1.158~1.947,P=0.002);TRIB2与免疫细胞的浸润密切相关,并且与免疫检查点分子表达水平以及TMB正相关(r=0.39,P<0.001);TRIB2的表达水平与免疫检查点抑制剂的疗效相关。结论 TRIB2在结肠癌中高表达且与结肠癌患者预后差和免疫微环境密切相关。
Objective To explore the expression of TRIB2 in colon cancer and its relationship with prognosis and immune cell infiltration. Methods TIMER database was used to analyse the expression of TRIB2 in pan-cancer.RNA-seq data and clinical information of colon cancer patients were downloaded from TCGA and GSE17538 to assess the correlation between TRIB2 with clinicopathological features.Survival curves,univariate and multivariate COX regression analysis were performed to explore the correlation between TRIB2 and prognosis,and a nomogram was constructed.Gene enrichment analyses were performed for TRIB2.Correlations between TRIB2 expression and immune cell infiltration,immune checkpoints,tumor mutation burden(TMB),and immunotherapy sensitivity were analyzed.Results TRIB2 was highly expressed in colon cancer tissues(P<0.05).The highest level of TRIB2 mRNA expression was found in CMS1.TRIB2 was an independent prognostic factor for colon cancer patients(univariate Cox regression analysis:HR=1.397,95%CI:1.100-1.774,P=0.006;multivariate Cox regression analysis:HR=1.502,95%CI:1.158-1.947,P=0.002).TRIB2 was closely associated with immune cell infiltration and positively correlated with the expression level of immune checkpoint molecules as well as TMB(r=0.39,P<0.001).The expression of TRIB2 was correlated with the efficacy of immune checkpoint inhibitors.Conclusions TRIB2 is highly expressed in colon cancer and is closely associated with poor prognosis and the immune microenvironment of colon cancer patients.
1、 GROSSER R,CHERKASSKY L,CHINTALA N,et al.Combination immunotherapy with CAR T cells and checkpoint blockade for the treatment of solid tumors[J].Cancer Cell,2019,36(5):471-482. GROSSER R,CHERKASSKY L,CHINTALA N,et al.Combination immunotherapy with CAR T cells and checkpoint blockade for the treatment of solid tumors[J].Cancer Cell,2019,36(5):471-482.
2、 SHOLL L M,HIRSCH F R,HWANG D,et al.The promises and challenges of tumor mutation burden as an immunotherapy biomarker:A perspective from the international association for the study of lung cancer pathology committee[J].J Thorac Oncol,2020,15(9):1409-1424. SHOLL L M,HIRSCH F R,HWANG D,et al.The promises and challenges of tumor mutation burden as an immunotherapy biomarker:A perspective from the international association for the study of lung cancer pathology committee[J].J Thorac Oncol,2020,15(9):1409-1424.
3、 LENZ H J,OU F S,VENOOK A P,et al.Impact of consensus molecular subtype on survival in patients with metastatic colorectal cancer:Results from CALGB/SWOG 80405(alliance)[J].J Clin Oncol,2019,37(22):1876-1885. LENZ H J,OU F S,VENOOK A P,et al.Impact of consensus molecular subtype on survival in patients with metastatic colorectal cancer:Results from CALGB/SWOG 80405(alliance)[J].J Clin Oncol,2019,37(22):1876-1885.
4、 GUINNEY J,DIENSTMANN R,WANG X,et al.The consensus molecular subtypes of colorectal cancer[J].Nat Med,2015,21(11):1350-1356. GUINNEY J,DIENSTMANN R,WANG X,et al.The consensus molecular subtypes of colorectal cancer[J].Nat Med,2015,21(11):1350-1356.
5、 LI K,WANG F,YANG Z N,et al.TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation[J].Nat Commun,2020,11(1):6316. LI K,WANG F,YANG Z N,et al.TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation[J].Nat Commun,2020,11(1):6316.
6、 LIANG K,O’CONNOR C,VEIGA J P,et al.TRIB2 regulates normal and stress-induced thymocyte proliferation[J].Cell Discov,2016(2):15050. LIANG K,O’CONNOR C,VEIGA J P,et al.TRIB2 regulates normal and stress-induced thymocyte proliferation[J].Cell Discov,2016(2):15050.
7、 LU H,SHI T,WANG M,et al.B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells[J].Oncoimmunology,2020,9(1):1748991. LU H,SHI T,WANG M,et al.B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells[J].Oncoimmunology,2020,9(1):1748991.
8、 WANG H,GAO Y,VAFAEI S,et al.A chemoresistance lncRNA signature for recurrence risk stratification of colon cancer patients with chemotherapy[J].Mol Ther Nucleic Acids,2022(27):427-438. WANG H,GAO Y,VAFAEI S,et al.A chemoresistance lncRNA signature for recurrence risk stratification of colon cancer patients with chemotherapy[J].Mol Ther Nucleic Acids,2022(27):427-438.
9、 NEWMAN A M,LIU C L,GREEN M R,et al.Robust enumeration of cell subsets from tissue expression profiles[J].Nat Methods,2015,12(5):453-457. NEWMAN A M,LIU C L,GREEN M R,et al.Robust enumeration of cell subsets from tissue expression profiles[J].Nat Methods,2015,12(5):453-457.
10、 YOSHIHARA K,SHAHMORADGOLI M,MARTíNEZ E,et al.Inferring tumour purity and stromal and immune cell admixture from expression data[J].Nat Commun,2013(4):2612. YOSHIHARA K,SHAHMORADGOLI M,MARTíNEZ E,et al.Inferring tumour purity and stromal and immune cell admixture from expression data[J].Nat Commun,2013(4):2612.
11、 HOU Z,GUO K,SUN X,et al.TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling[J].Mol Cancer,2018,17(1):172. HOU Z,GUO K,SUN X,et al.TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling[J].Mol Cancer,2018,17(1):172.
12、 MAI Z,GUO K,SUN X,et al.Expression and related mechanisms of miR-100 and TRIB2 in COPD patients[J].J Healthc Eng,2022(2022):6556208. MAI Z,GUO K,SUN X,et al.Expression and related mechanisms of miR-100 and TRIB2 in COPD patients[J].J Healthc Eng,2022(2022):6556208.
13、 GUO S,CHEN Y,XUE X,et al.TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells[J].Cell Death Discov,2021,7(1):196. GUO S,CHEN Y,XUE X,et al.TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells[J].Cell Death Discov,2021,7(1):196.
14、 MAYORAL-VARO V,JIMéNEZ L,LINK W,The critical role of TRIB2 in cancer and therapy resistance[J].Cancers(Basel),2021,13(11):2701. MAYORAL-VARO V,JIMéNEZ L,LINK W,The critical role of TRIB2 in cancer and therapy resistance[J].Cancers(Basel),2021,13(11):2701.
15、 ROME K S,STEIN S J,KURACHI M,et al.Trib1 regulates T cell differentiation during chronic infection by restraining the effector program[J].J Exp Med,2020,217(5):e20190888. ROME K S,STEIN S J,KURACHI M,et al.Trib1 regulates T cell differentiation during chronic infection by restraining the effector program[J].J Exp Med,2020,217(5):e20190888.
16、 LIU Y R,SONG D D,LIANG D M,et al.Oncogenic TRIB2 interacts with and regulates PKM2 to promote aerobic glycolysis and lung cancer cell procession[J].Cell Death Discov,2022,8(1):306. LIU Y R,SONG D D,LIANG D M,et al.Oncogenic TRIB2 interacts with and regulates PKM2 to promote aerobic glycolysis and lung cancer cell procession[J].Cell Death Discov,2022,8(1):306.
17、 LIU I D,WILLIS N S,CRAIG J C,et al.Interventions for idiopathic steroid-resistant nephrotic syndrome in children[J].Cochrane Database Syst Rev,2019,2019(11):CD003594. LIU I D,WILLIS N S,CRAIG J C,et al.Interventions for idiopathic steroid-resistant nephrotic syndrome in children[J].Cochrane Database Syst Rev,2019,2019(11):CD003594.
18、 OLIVEIRA A F,BRETES L,FURTADO I.Review of PD-1/PD-L1 inhibitors in metastatic dMMR/MSI-H colorectal cancer[J].Front Oncol,2019(9):396. OLIVEIRA A F,BRETES L,FURTADO I.Review of PD-1/PD-L1 inhibitors in metastatic dMMR/MSI-H colorectal cancer[J].Front Oncol,2019(9):396.
19、 PETERSON C,DENLINGER N,YANG Y.Recent advances and challenges in cancer immunotherapy[J].Cancers(Basel),2022,14(16):3972. PETERSON C,DENLINGER N,YANG Y.Recent advances and challenges in cancer immunotherapy[J].Cancers(Basel),2022,14(16):3972.
20、 NTAVATZIKOS A,SPATHIS A,PATAPIS P,et al.TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer[J].World J Gastrointest Oncol,2019,11(7):551-566. NTAVATZIKOS A,SPATHIS A,PATAPIS P,et al.TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer[J].World J Gastrointest Oncol,2019,11(7):551-566.
21、 BREAKSTONE R.Colon cancer and immunotherapy-can we go beyond microsatellite instability?[J].Transl Gastroenterol Hepatol,2021(6):12. BREAKSTONE R.Colon cancer and immunotherapy-can we go beyond microsatellite instability?[J].Transl Gastroenterol Hepatol,2021(6):12.
22、 BRAY F,LAVERSANNE M,SUNG H,et al.Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2024,74(3):229-263. BRAY F,LAVERSANNE M,SUNG H,et al.Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2024,74(3):229-263.
23、 黄庆,索彩霞,何凤,等.结直肠癌的早期诊断策略和治疗进展[J].广州医药,2024.55(1):1-8. 黄庆,索彩霞,何凤,等.结直肠癌的早期诊断策略和治疗进展[J].广州医药,2024.55(1):1-8.
24、 SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics,2019[J].CA Cancer J Clin,2019,69(1):7-34. SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics,2019[J].CA Cancer J Clin,2019,69(1):7-34.
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