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2023年7月 第38卷 第7期11
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Wnt/β-catenin信号通路在心肌纤维化中的作用研究进展

Research progress on the role of Wnt / β-catenin signaling pathway in myocardial fibrosis

来源期刊: 广州医药 | 85-90 发布时间:2024-01-24 收稿时间:2025/11/13 18:51:59 阅读量:87
作者:
关键词:
Wnt/β-catenin心肌纤维化心血管疾病
Wnt / β-cateninmyocardial fibrosiscardiovascular disease
DOI:
10.3969/j.issn.1000-8535.2024.01.015
收稿时间:
2023-08-07 
修订日期:
 
接收日期:
 
引用总数:
6  
Wnt/β-catenin信号通路是一种在胚胎发育,细胞增殖分化、迁移,干细胞更新等中起关键作用的蛋白质家族。Wnt/β-catenin信号通路的失调常常会导致各种严重的疾病,例如肿瘤、心脏疾病、肺部疾病、肝脏疾病、骨骼疾病、神经疾病等。大量研究表明,Wnt/β-catenin信号通路在心肌纤维化发病机制中起重要作用,本文结合最新研究成果,从心肌纤维化相关疾病的角度对Wnt/β-catenin通路进行综述,为预防心肌纤维化提供新的思路,进一步达到防治心血管疾病的目的。
The Wnt/β-catenin signaling pathway is a family of proteins that play a key role in embryonic development,cell proliferation and differentiation,migration,stem cell renewal,etc.Dysfunctions of Wnt/β-catenin signaling pathway often lead to various serious diseases,such as tumor,heart,lung,liver,bone and neurological diseases,etc.Numerous studies have shown that the Wnt/β-catenin signaling pathway plays an important role in the pathogenesis of cardiac fibrosis.This article,in combination with the latest research findings,presents a review of the Wnt/β-catenin pathway from the perspective of myocardial fibrosis-related diseases,in order to provide new ideas for preventing myocardial fibrosis and achieving the goal of combating cardiovascular disease.
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1、张晓红.西妥昔单抗通过激活PLCB3/Wnt/β—Catenin信号通路抑制EGFR泛素化并抑制结直肠癌进展的机制研究[D].锦州医科大学,2024.DOI:10.27812/d.cnki.glnyx.2024.000910. 张晓红.西妥昔单抗通过激活PLCB3/Wnt/β—Catenin信号通路抑制EGFR泛素化并抑制结直肠癌进展的机制研究[D].锦州医科大学,2024.DOI:10.27812/d.cnki.glnyx.2024.000910.
2、高雅婷.人参皂苷Rg1调控Wnt1/β-Catenin通路减轻心肌纤维化的研究[D].南京中医药大学,2024.DOI:10.27253/d.cnki.gnjzu.2024.000289. 高雅婷.人参皂苷Rg1调控Wnt1/β-Catenin通路减轻心肌纤维化的研究[D].南京中医药大学,2024.DOI:10.27253/d.cnki.gnjzu.2024.000289.
3、黄昕.针刺调控wnt/β—catenin通路防治女运动员三联征骨质疏松机制研究[D].广州中医药大学,2024.DOI:10.27044/d.cnki.ggzzu.2024.000766. 黄昕.针刺调控wnt/β—catenin通路防治女运动员三联征骨质疏松机制研究[D].广州中医药大学,2024.DOI:10.27044/d.cnki.ggzzu.2024.000766.
4、班江文.珍珠舌草胶囊调控萎缩性胃炎大鼠Wnt/β-catenin信号通路的机制研究[D].山西省中医药研究院,2024.DOI:10.27286/d.cnki.gsxzy.2024.000020. 班江文.珍珠舌草胶囊调控萎缩性胃炎大鼠Wnt/β-catenin信号通路的机制研究[D].山西省中医药研究院,2024.DOI:10.27286/d.cnki.gsxzy.2024.000020.
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