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弥漫性大B细胞淋巴瘤的放射治疗进展

Recent progress in radiation therapy for diffuse large B-cell lymphoma

来源期刊: 广州医药 | 974-984 发布时间:2024-10-22 收稿时间:2025/11/13 18:45:06 阅读量:37
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关键词:
弥漫性大B细胞淋巴瘤放射治疗复发性/难治性弥漫性大B细胞淋巴瘤利妥昔单抗
diffuse large B-cell lymphomaradiation therapyrelapsed / refractory DLBCLrituximab
DOI:
10.3969/j.issn.1000-8535.2024.09.002
收稿时间:
2024-05-18 
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接收日期:
 
引用总数:
1  
弥漫性大B细胞淋巴瘤(DLBCL)是最常见的高度异质性非霍奇金淋巴瘤(NHL),不同的疾病阶段或临床亚型预后不尽相同。放射治疗作为无交叉耐药的理想局部治疗技术,应用于DLBCL可有效改善患者预后。初治DLBCL通过放射治疗联合化学治疗、免疫治疗等综合治疗可使约60%~70%患者疾病缓解。对于不同预后影响因素,如年龄、肿瘤体积、淋巴结外侵犯等,联合放射治疗也可取得更佳疗效。在复发性/难治性DLBCL的治疗中,自体造血干细胞移植(ASCT)和嵌合抗原受体T细胞免疫治疗(CAR-T)是目前的研究热点,而放射治疗无论是作为ASCT与CAR-T术前的桥接治疗或失败后的挽救性治疗均有助改善患者预后。随着放射治疗技术的日益优化,放射治疗在综合治疗方案中扮演着越来越重要的角色。
Diffuse large B-cell lymphoma(DLBCL)is a highly heterogeneous type of non-Hodgkin lymphoma(NHL)and its prognosis is different for different disease stages or clinical subtypes.Radiation therapy(RT)is a local treatment technique that does not cause cross-resistance and can effectively improve the prognosis of patients with DLBCL.When combined with chemotherapy and immunotherapy,RT can alleviate the disease in more than 60% of patients.Furthermore,RT can achieve better results for different prognostic factors such as age,tumor volume and external nodal invasion.For treating relapsed / refractory DLBCL,autologous stem cell transplantation(ASCT)and chimeric antigen receptor T cell immunotherapy(CAR-T)are currently being researched,while RT can help as bridging therapy before ASCT and CAR-T or salvage therapy after failure.With the increasing optimization of technology,radiotherapy plays an increasingly important role in combined treatment options.
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1、杜均如.原发胃肠道淋巴瘤多中心回顾性分析及其亚型为弥漫大B细胞淋巴瘤的预后模型构建[D].南方医科大学,2025.DOI:10.27003/d.cnki.gojyu.2025.000853. 杜均如.原发胃肠道淋巴瘤多中心回顾性分析及其亚型为弥漫大B细胞淋巴瘤的预后模型构建[D].南方医科大学,2025.DOI:10.27003/d.cnki.gojyu.2025.000853.
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