复方甘草酸苷联合卡泊三醇乳膏治疗寻常型银屑病的效果观察

来源期刊：广州医药 | 1172-1176 发布时间：2024-11-05 收稿时间：2025/11/13 18:44:23 阅读量：30

作者：: 马雪姣,

聂丽,

沈路路,

王环,

黄宽,

姜永刚,

关键词：: 复方甘草酸苷卡泊三醇乳膏寻常型银屑病; compound glycyrrhetinic acid glycoside capotriol cream psoriasis vulgaris

DOI：: 10.20223/j.cnki.1000-8535.2024.10.012

收稿时间：: 2024-01-08
修订日期：
接收日期：
引用总数：: 1

目的探讨复方甘草酸苷联合卡泊三醇乳膏治疗寻常型银屑病的效果观察。方法选取辽健集团阜新矿总医院2019年12月—2022年12月收治的96例寻常型银屑病患者,分为联合组与对照组,每组48例。对照组使用卡泊三醇乳膏治疗,联合组在对照组基础上联用复方甘草酸苷治疗,对比临床疗效,以皮质含量、经表皮水分流失（TEWL）、角质层水含量变化评价患者的皮肤屏障功能,并对比两组患者治疗前后T细胞相关炎症因子表达水平。结果联合组治疗总有效率较对照组高[93.75% vs 77.08%,χ²=5.352,P=0.021];治疗后两组皮质含量、角质层水含量升高,联合组高于对照组,TEWL降低,联合组低于对照组[皮质含量：（73.59±7.24）μg/cm² vs（110.12±13.64）μg/cm²,t=16.389,P<0.001;角质层水含量：（25.28±3.25）% vs（16.24±2.14）%,t=16.095,P<0.001;TEWL：（8.06±1.44）g/（h·m²）vs（11.71±2.68）g/（h·m²）,t=8.312,P<0.001];治疗后两组患者白细胞介素-2（IL-2）、白细胞介素-6（IL-6）、γ干扰素（IFN-γ）表达水平均降低,且联合组低于对照组[IL-2：（22.25±3.32）vs（26.62±3.24）pg/mL,t=6.661,P<0.001;IL-6：（80.46±5.11）vs（112.62±12.16）pg/mL,t=16.892,P<0.001;IFN-γ：（68.62±10.73）vs（51.26±6.37）ng/L,t=9.639,P<0.001]。结论复方甘草酸苷联合卡泊三醇乳膏可改善寻常型银屑病皮肤屏障功能,降低炎症因子,改善Th1/Th2细胞因子失衡情况。

Objective To investigate the effect of compound glycyrrhizin and caspotriol cream in psoriasis vulgaris. Methods The 96 psoriasis patients admitted to Fuxin Mine General Hospital from December 2019 to December 2022 were selected and divided into combined group and control group,with 48 patients in each group．The control group was treated with caspotriol cream,the combined group treated with compound glycyrrhizin treatment,the clinical efficacy was compared,and the skin barrier function of patients was evaluated by cortical content,transepidermal water loss（TEWL）,and changes in stratum corneum water content．The expression levels of T cell related inflammatory factors before and after treatment were compared between the two groups. Results The overall effective treatment rate in the combined group was higher than in the control group[93.75% vs 77.08%,χ²=5.352,P=0.021]．After treatment,cortical and stratum corneum water levels increased in both groups,with the combined group being higher than the control group．TEWL decreased and the combined group was lower than the control group[cortical content：（73.59±7.24）μg/cm² vs（110.12±13.64）μg/cm²,t=16.389,P<0.001;water content in the stratum corneum：（25.28±3.25）% vs（16.24±2.14）%,t=16.095,P<0.001;TEWL：（8.06±1.44）g/（h·m²）vs（11.71±2.68）g/（h·m²）,t=8.312,P<0.001]．After treatment,two groups of patients were treated with interleukin-2（IL-2）,interleukin-6（IL-6） and interferon（IFN）-γ,and the combined group was lower than the control group[IL-2：（22.25±3.32）pg/mL vs（26.62±3.24）pg/mL,t=6.661,P<0.001;IL-6：（80.46±5.11）pg/mL vs（112.62±12.16）pg/mL,t=16.892,P<0.001;IFN-γ：（68.62±10.73）ng/L vs（51.26±6.37）ng/L,t=9.639,P<0.001]. Conclusions The combination of compound glycyrrhizin and carpotriol cream can improve the skin barrier function of psoriasis vulgaris,reduce inflammatory factors,and improve the imbalance of Th1/Th2 cytokines．

1、欧阳飞,刘婷婷,房慧,等.富马酸卢帕他定联合复方甘草酸苷治疗慢性荨麻疹疗效观察[J].重庆医学,2022,51(S01):238-240.

2、杨琦,雒姣,廖静.卡泊三醇软膏联合地奈德乳膏在慢性湿疹患者中的应用效果[J].山西医药杂志,2022,51(5):522-524.

3、 JENSEN K K,SERUP J,ALSING K K.Psoriasis and seasonal variation:A systematic review on reports from Northern and Central Europe-Little overall variation but distinctive subsets with improvement in summer or wintertime[J].Skin Res Technol,2022,28(1):180-186.

4、张亮,唐城,薛红瑞,等.复方甘草酸苷片中三种活性成分在四种不同溶出介质中溶出曲线的测定[J].新疆医科大学学报,2023,46(1):9-15.

5、 NORDEN A,OULEE A,MUNAWAR L,et al.Anti-drug antibodies of IL-17 inhibitors for psoriasis:A systematic review[J].J Dermatolog Treat,2022,33(8):3080-3085.

6、陆明敏,乔丽,白明明,等.寻常型银屑病患者皮肤屏障功能相关指标检测分析[J].中国麻风皮肤病杂志,2022,38(11):797-799.

7、李妍,李明,徐薇,等.丙酸氟替卡松乳膏单独或联合卡泊三醇软膏治疗轻中度斑块状银屑病的随机自身对照研究[J].中华皮肤科杂志,2022,55(3):260-263.

8、王晓晓,李青青.308 nm准分子激光联合复方甘草酸苷片对白癜风患者T细胞亚群及血清ICAM-1、SOD的影响[J].中国医药导刊,2023,25(1):71-75.

9、张玲玲,刘佳.复方甘草酸苷胶囊对系统性红斑狼疮患者免疫应激反应的调节作用研究[J].现代中西医结合杂志,2021,30(24):2708-2711.

10、陈小英,莫伟英,张冠文.复方甘草酸苷与雷公藤多苷在银屑病中的治疗效果[J].慢性病学杂志,2022(5):770-773.

11、 BERTH-JONES J.,GROTZINGER K,RAINVILLE C.等.一项评价银屑病严重程度的3种量表(银屑病面积和严重性指数、医师全面评估指标和点阵系统医师)的评定者之间和之内可靠性的研究[J].世界核心医学期刊文摘(皮肤病学分册),2006(12):12.

12、朱学骏. 组织病理学在临床皮肤科学中的作用与地位——通过临床学习皮肤组织病理学[C]// 中华中医药学会皮肤科分会学术会议、全国中医药防治皮肤病成果与技术交流大会、全国中西医结合皮肤科治疗新技术临床推广应用高级研修班文献汇编. 2004.

13、栾冰,信琪琪,王丽丹,等.复方甘草酸苷制剂联合雷公藤多苷治疗银屑病的meta分析[J].国际中医中药杂志,2021,43(4):403-408.

14、曾芬,饶美荣,张佳音,等.复方甘草酸苷调控miR-155对寻常型银屑病表皮细胞细胞周期的影响[J].中国免疫学杂志,2021,37(24):2976-2980.

15、蒋晓妍,刘克帅,张晓艳.阿维A胶囊联合复方甘草酸苷治疗红皮病型银屑病的疗效及安全性Meta分析[J].中国中西医结合杂志,2022,42(5):568-574.

16、于伟,王娟,肖春才.银屑胶囊联合卡泊三醇软膏治疗寻常型银屑病对炎症反应及复发的影响[J].辽宁中医杂志,2023,50(8):169-172.

17、翟伟,孟静,王倩,等.疗癣卡西甫丸联合卡泊三醇乳膏治疗寻常型银屑病的临床研究[J].现代药物与临床,2022,37(5):1081-1084.

18、张琪,李改叶,刘保国,等.八宝五胆药墨联合卡泊三醇软膏治疗儿童点滴状银屑病的疗效观察[J].中国中西医结合皮肤性病学杂志,2021,20(5):474-476.

19、马卉,毕晓东.寻常型银屑病皮损中CXCL8、miR-150表达与病情严重程度相关[J].基础医学与临床,2023,43(2):293-297.

20、 PARISI R,ISKANDAR I Y K,KONTOPANTELIS E,et al.National,regional,and worldwide epidemiology of psoriasis:Systematic analysis and modelling study[J].BMJ,2020,369(5):m1590.

21、吴治民,段行武,李峻崎,等.寻常型银屑病患者焦虑与病情、氧化应激及炎症因子的相关性研究[J].海南医学院学报,2023,29(3):203-209.

22、 SBIDIAN E,CHAIMANI A,GARCIA-DOVAL I,et al.Systemic pharmacological treatments for chronic plaque psoriasis:A network meta-analysis[J].Cochrane Database Syst Rev,2022,5(5):CD011535.

1、沈博芳.105例血热证白疕住院患者的回顾性分析[D].辽宁中医药大学,2025.DOI:10.27213/d.cnki.glnzc.2025.000327.