您的位置: 首页 > 2024年10月 第55卷 第10期 > 文字全文
2023年7月 第38卷 第7期11
目录

长链非编码RNA在消化道肿瘤中的研究进展

Long non-coding RNAs in human gastrointestinal cancer

来源期刊: 广州医药 | 1105-1112 发布时间:2024-11-05 收稿时间:2025/11/13 18:43:52 阅读量:167
作者:
关键词:
长链非编码RNA消化道肿瘤作用机制基因调控
long non-coding RNAsgastrointestinal cancermechanismsregulation of gene expression
DOI:
10.20223/j.cnki.1000-8535.2024.10.001
收稿时间:
2024-08-07 
修订日期:
 
接收日期:
 
引用总数:
0  
在过去的几十年中,随着RNA生物学的深入研究,越来越多的证据表明,非编码RNA(ncRNA)对包括癌症在内的多种疾病进展起着关键作用,同时在作为生物标志物和治疗靶点方面表现出了巨大的潜力。在全球范围内,消化道(GI)肿瘤是肿瘤相关死亡的主要原因,目前消化道肿瘤晚期患者的生存率依然很低。既往大量研究报道了ncRNA中,特别是长链非编码RNA(lncRNA)在消化道肿瘤发生发展中发挥重要作用。本文将着重阐述lncRNA在消化道肿瘤分子生物学中的作用,旨在为深入理解lncRNA在消化道肿瘤发生发展机制以及临床转化应用提供新的思路和线索。
In recent decades,an increasing body of evidence has pointed to the pivotal roles of non-coding RNAs(ncRNAs),particularly long non-coding RNAs(lncRNAs),in the development of various diseases,including cancer.Meanwhile,ncRNAs have been shown great potential as biomarker and therapeutic target.Gastrointestinal(GI)cancers are a leading cause of cancer-related mortality globally and the survival rate of advanced GI cancer patients is still very low.Extensive research has underscored the significant involvement of lncRNAs in the initiation and progression of GI cancers.This review aims to offer a comprehensive overview of lncRNAs,shedding light on their roles in the molecular biology of GI cancers.By synthesizing previous studies,this review seeks to provide new insights into the mechanisms underlying lncRNAs' contribution to GI cancer development and their potential clinical applications.
1、 BESTER A C,LEE J D,CHAVEZ A,et al.An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance[J].Cell,2018,173(3):649-664.e20. BESTER A C,LEE J D,CHAVEZ A,et al.An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance[J].Cell,2018,173(3):649-664.e20.
2、 COUTINHO M F,MATOS L,SANTOS J I,et al.RNA Therapeutics:How Far Have We Gone?[J].Adv Exp Med Biol,2019(1157):133-177. COUTINHO M F,MATOS L,SANTOS J I,et al.RNA Therapeutics:How Far Have We Gone?[J].Adv Exp Med Biol,2019(1157):133-177.
3、 MATSUI M,COREY D R.Non-coding RNAs as drug targets[J].Nat Rev Drug Discov,2017,16(3):167-79. MATSUI M,COREY D R.Non-coding RNAs as drug targets[J].Nat Rev Drug Discov,2017,16(3):167-79.
4、 ZHOU L Y,QIN Z,ZHU Y H,et al.Current RNA-based Therapeutics in Clinical Trials[J].Current Gene ther,2019,19(3):172-96. ZHOU L Y,QIN Z,ZHU Y H,et al.Current RNA-based Therapeutics in Clinical Trials[J].Current Gene ther,2019,19(3):172-96.
5、 HAGENACKER T,WURSTER C D,GüNTHER R,et al.Nusinersen in adults with 5q spinal muscular atrophy:a non-interventional,multicentre,observational cohort study[J].Lancet Neurol,2020,19(4):317-25. HAGENACKER T,WURSTER C D,GüNTHER R,et al.Nusinersen in adults with 5q spinal muscular atrophy:a non-interventional,multicentre,observational cohort study[J].Lancet Neurol,2020,19(4):317-25.
6、 BAO Y,TANG J,QIAN Y,et al.Long noncoding RNA BFAL1 mediates enterotoxigenic Bacteroides fragilis-related carcinogenesis in colorectal cancer via the RHEB/mTOR pathway[J].Cell Death Dis,2019,10(9):675. BAO Y,TANG J,QIAN Y,et al.Long noncoding RNA BFAL1 mediates enterotoxigenic Bacteroides fragilis-related carcinogenesis in colorectal cancer via the RHEB/mTOR pathway[J].Cell Death Dis,2019,10(9):675.
7、 YU T,ZHAO Y,HU Z,et al.MetaLnc9 facilitates lung cancer metastasis via a PGK1-Activated AKT/mTOR Pathway[J].Cancer Res,2017,77(21):5782-5794. YU T,ZHAO Y,HU Z,et al.MetaLnc9 facilitates lung cancer metastasis via a PGK1-Activated AKT/mTOR Pathway[J].Cancer Res,2017,77(21):5782-5794.
8、 GUTSCHNER T,H?MMERLE M,DIEDERICHS S.MALAT1 -- a paradigm for long noncoding RNA function in cancer[J].J Mol Med(Berl),2013,91(7):791-801. GUTSCHNER T,H?MMERLE M,DIEDERICHS S.MALAT1 -- a paradigm for long noncoding RNA function in cancer[J].J Mol Med(Berl),2013,91(7):791-801.
9、 ZHOU J,ZHI X,WANG L,et al.Linc00152 promotes proliferation in gastric cancer through the EGFR-dependent pathway[J].J Exp Clin Cancer Res :CR,2015(34):135. ZHOU J,ZHI X,WANG L,et al.Linc00152 promotes proliferation in gastric cancer through the EGFR-dependent pathway[J].J Exp Clin Cancer Res :CR,2015(34):135.
10、 GUO F X,WU Q,LI P,et al.The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling[J].Cell Death Differ,2019,26(9):1670-1687. GUO F X,WU Q,LI P,et al.The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling[J].Cell Death Differ,2019,26(9):1670-1687.
11、 WU Z R,YAN L,LIU Y T,et al.Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours[J].Nat Commun,2018,9(1):4624. WU Z R,YAN L,LIU Y T,et al.Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours[J].Nat Commun,2018,9(1):4624.
12、 LIU X,XIAO Z D,HAN L,et al.LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress[J].Nat Cell Biol,2016,18(4):431-442. LIU X,XIAO Z D,HAN L,et al.LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress[J].Nat Cell Biol,2016,18(4):431-442.
13、 CHEN J F,WU P,XIA R,et al.STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy[J].Mol Cancer,2018,17(1):6. CHEN J F,WU P,XIA R,et al.STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy[J].Mol Cancer,2018,17(1):6.
14、 LI X,LI Z,LIU Z,et al.Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2[J].Cancer Gene ther,2018,25(3-4):58-67. LI X,LI Z,LIU Z,et al.Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2[J].Cancer Gene ther,2018,25(3-4):58-67.
15、 LIU T,HAN Z,LI H,et al.LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3[J].Mol Cancer,2018,17(1):118. LIU T,HAN Z,LI H,et al.LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3[J].Mol Cancer,2018,17(1):118.
16、 ZHAO Q,ZHAO Y,HU W,et al.m(6)A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer[J].Theranostics,2020,10(21):9528-9543. ZHAO Q,ZHAO Y,HU W,et al.m(6)A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer[J].Theranostics,2020,10(21):9528-9543.
17、 WU G,CAI J,HAN Y,et al.LincRNA-p21 regulates neointima formation,vascular smooth muscle cell proliferation,apoptosis,and atherosclerosis by enhancing p53 activity[J].Circulation,2014,130(17):1452-1465. WU G,CAI J,HAN Y,et al.LincRNA-p21 regulates neointima formation,vascular smooth muscle cell proliferation,apoptosis,and atherosclerosis by enhancing p53 activity[J].Circulation,2014,130(17):1452-1465.
18、 LIN J,TAN X,QIU L,et al.Long Noncoding RNA BC032913 as a novel therapeutic target for colorectal cancer that suppresses metastasis by upregulating TIMP3[J].Mol Ther Nucleic Acids,2017(8):469-481. LIN J,TAN X,QIU L,et al.Long Noncoding RNA BC032913 as a novel therapeutic target for colorectal cancer that suppresses metastasis by upregulating TIMP3[J].Mol Ther Nucleic Acids,2017(8):469-481.
19、 ZHANG Z,ZHOU C,CHANG Y,et al.Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/β-catenin pathway to promote growth and metastasis in colorectal cancer[J].Cancer Lett,2016,376(1):62-73. ZHANG Z,ZHOU C,CHANG Y,et al.Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/β-catenin pathway to promote growth and metastasis in colorectal cancer[J].Cancer Lett,2016,376(1):62-73.
20、 LIU Y,SETHI N S,HINOUE T,et al.Comparative molecular analysis of gastrointestinal adenocarcinomas[J].Cancer Cell,2018,33(4):721-735.e8. LIU Y,SETHI N S,HINOUE T,et al.Comparative molecular analysis of gastrointestinal adenocarcinomas[J].Cancer Cell,2018,33(4):721-735.e8.
21、 GUINNEY J,DIENSTMANN R,WANG X,et al.The consensus molecular subtypes of colorectal cancer[J].Nat Med,2015,21(11):1350-1356. GUINNEY J,DIENSTMANN R,WANG X,et al.The consensus molecular subtypes of colorectal cancer[J].Nat Med,2015,21(11):1350-1356.
22、 SáNCHEZ-DANéS A,BLANPAIN C.Deciphering the cells of origin of squamous cell carcinomas[J].Nature reviews Cancer,2018,18(9):549-561. SáNCHEZ-DANéS A,BLANPAIN C.Deciphering the cells of origin of squamous cell carcinomas[J].Nature reviews Cancer,2018,18(9):549-561.
23、 Cancer Genome Atlas Research Network.Comprehensive molecular characterization of gastric adenocarcinoma[J].Nature,2014,513(7517):202-209. Cancer Genome Atlas Research Network.Comprehensive molecular characterization of gastric adenocarcinoma[J].Nature,2014,513(7517):202-209.
24、 GRADY W M,CARETHERS J M.Genomic and epigenetic instability in colorectal cancer pathogenesis[J].Gastroenterology,2008,135(4):1079-1099. GRADY W M,CARETHERS J M.Genomic and epigenetic instability in colorectal cancer pathogenesis[J].Gastroenterology,2008,135(4):1079-1099.
25、 ZACK T I,SCHUMACHER S E,CARTER S L,et al.Pan-cancer patterns of somatic copy number alteration[J].Nat Genet,2013,45(10):1134-1140. ZACK T I,SCHUMACHER S E,CARTER S L,et al.Pan-cancer patterns of somatic copy number alteration[J].Nat Genet,2013,45(10):1134-1140.
26、 SANSREGRET L,VANHAESEBROECK B,SWANTON C.Determinants and clinical implications of chromosomal instability in cancer[J].Nat Rev Clin Oncol,2018,15(3):139-150. SANSREGRET L,VANHAESEBROECK B,SWANTON C.Determinants and clinical implications of chromosomal instability in cancer[J].Nat Rev Clin Oncol,2018,15(3):139-150.
27、 ZHANG Y,CHEN L.Classification of advanced human cancers based on tumor immunity in the microEnvironment(TIME)for cancer immunotherapy[J].JAMA Oncol,2016,2(11):1403-1404. ZHANG Y,CHEN L.Classification of advanced human cancers based on tumor immunity in the microEnvironment(TIME)for cancer immunotherapy[J].JAMA Oncol,2016,2(11):1403-1404.
28、 HANAHAN D.Hallmarks of Cancer:New Dimensions[J].Cancer Discov,2022,12(1):31-46. HANAHAN D.Hallmarks of Cancer:New Dimensions[J].Cancer Discov,2022,12(1):31-46.
29、 RAAB J R,SMITH K N,SPEAR C C,et al.SWI/SNF remains localized to chromatin in the presence of SCHLAP1[J].Nat Genet,2019,51(1):26-29. RAAB J R,SMITH K N,SPEAR C C,et al.SWI/SNF remains localized to chromatin in the presence of SCHLAP1[J].Nat Genet,2019,51(1):26-29.
30、 SCHMITT A M,GARCIA J T,HUNG T,et al.An inducible long noncoding RNA amplifies DNA damage signaling[J].Nat Genet,2016,48(11):1370-1376. SCHMITT A M,GARCIA J T,HUNG T,et al.An inducible long noncoding RNA amplifies DNA damage signaling[J].Nat Genet,2016,48(11):1370-1376.
31、 LIU B,SUN L,LIU Q,et al.A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis[J].Cancer Cell,2015,27(3):370-381. LIU B,SUN L,LIU Q,et al.A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis[J].Cancer Cell,2015,27(3):370-381.
32、 HUNG C L,WANG L Y,YU Y L,et al.A long noncoding RNA connects c-Myc to tumor metabolism[J].Proc Natl Acad Sci U S A,2014,111(52):18697-18702. HUNG C L,WANG L Y,YU Y L,et al.A long noncoding RNA connects c-Myc to tumor metabolism[J].Proc Natl Acad Sci U S A,2014,111(52):18697-18702.
33、 LIU J,BEN Q,LU E,et al.Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer[J].Cell Death Dis,2018,9(2):168. LIU J,BEN Q,LU E,et al.Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer[J].Cell Death Dis,2018,9(2):168.
34、 KINO T,HURT D E,ICHIJO T,et al.Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor[J].Sci Signal,2010,3(107):ra8. KINO T,HURT D E,ICHIJO T,et al.Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor[J].Sci Signal,2010,3(107):ra8.
35、 HUDSON W H,PICKARD M R,de VERA I M,et al.Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate[J].Nat Commun,2014(5):5395. HUDSON W H,PICKARD M R,de VERA I M,et al.Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate[J].Nat Commun,2014(5):5395.
36、 ZHANG B,ARUN G,MAO Y S,et al.The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult[J].Cell Rep,2012,2(1):111-123. ZHANG B,ARUN G,MAO Y S,et al.The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult[J].Cell Rep,2012,2(1):111-123.
37、 NAKAGAWA S,IP J Y,SHIOI G,et al.Malat1 is not an essential component of nuclear speckles in mice[J].RNA(New York,NY),2012,18(8):1487-1499. NAKAGAWA S,IP J Y,SHIOI G,et al.Malat1 is not an essential component of nuclear speckles in mice[J].RNA(New York,NY),2012,18(8):1487-1499.
38、 SUN Q,HAO Q,PRASANTH K V.Nuclear Long Noncoding RNAs:Key Regulators of Gene Expression[J].Trends Genet,2018,34(2):142-157. SUN Q,HAO Q,PRASANTH K V.Nuclear Long Noncoding RNAs:Key Regulators of Gene Expression[J].Trends Genet,2018,34(2):142-157.
39、 KOPP F,MENDELL J T.Functional classification and experimental dissection of long noncoding RNAs[J].Cell,2018,172(3):393-407. KOPP F,MENDELL J T.Functional classification and experimental dissection of long noncoding RNAs[J].Cell,2018,172(3):393-407.
40、 WEST J A,DAVIS C P,SUNWOO H,et al.The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites[J].Mol Cell,2014,55(5):791-802. WEST J A,DAVIS C P,SUNWOO H,et al.The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites[J].Mol Cell,2014,55(5):791-802.
41、 ENGREITZ J M,SIROKMAN K,MCDONEL P,et al.RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites[J].Cell,2014,159(1):188-199. ENGREITZ J M,SIROKMAN K,MCDONEL P,et al.RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites[J].Cell,2014,159(1):188-199.
42、 SPECTOR D L,LAMOND A I.Nuclear speckles[J].Cold Spring Harbor perspectives in biology,2011,3(2):a000646. SPECTOR D L,LAMOND A I.Nuclear speckles[J].Cold Spring Harbor perspectives in biology,2011,3(2):a000646.
43、 WANG Y,HU S B,WANG M R,et al.Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria[J].Nat Cell Biol,2018,20(10):1145-1158. WANG Y,HU S B,WANG M R,et al.Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria[J].Nat Cell Biol,2018,20(10):1145-1158.
44、 LIN Y,SCHMIDT B F,BRUCHEZ M P,et al.Structural analyses of NEAT1 lncRNAs suggest long-range RNA interactions that may contribute to paraspeckle architecture[J].Nucleic Acids Res,2018,46(7):3742-3752. LIN Y,SCHMIDT B F,BRUCHEZ M P,et al.Structural analyses of NEAT1 lncRNAs suggest long-range RNA interactions that may contribute to paraspeckle architecture[J].Nucleic Acids Res,2018,46(7):3742-3752.
45、 TAKAKUWA H,YAMAZAKI T,SOUQUERE S,et al.Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles[J].Nat Cell Biol,2023,25(11):1664-1675. TAKAKUWA H,YAMAZAKI T,SOUQUERE S,et al.Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles[J].Nat Cell Biol,2023,25(11):1664-1675.
46、 GOYAL B,YADAV S R M,AWASTHEE N,et al.Diagnostic,prognostic,and therapeutic significance of long non-coding RNA MALAT1 in cancer[J].Biochim Biophys Acta Rev Cancer,2021,1875(2):188502. GOYAL B,YADAV S R M,AWASTHEE N,et al.Diagnostic,prognostic,and therapeutic significance of long non-coding RNA MALAT1 in cancer[J].Biochim Biophys Acta Rev Cancer,2021,1875(2):188502.
47、 AN H,ELVERS K T,GILLESPIE J A,et al.A toolkit for the identification of NEAT1_2/paraspeckle modulators[J].Nucleic Acids Res,2022,50(20):e119. AN H,ELVERS K T,GILLESPIE J A,et al.A toolkit for the identification of NEAT1_2/paraspeckle modulators[J].Nucleic Acids Res,2022,50(20):e119.
48、 YAP K L,LI S,MU?OZ-CABELLO A M,et al.Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a[J].Mol Cell,2010,38(5):662-674. YAP K L,LI S,MU?OZ-CABELLO A M,et al.Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a[J].Mol Cell,2010,38(5):662-674.
49、 WASSON C W,ABIGNANO G,HERMES H,et al.Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH[J].Ann Rheum Dis,2020,79(4):507-517. WASSON C W,ABIGNANO G,HERMES H,et al.Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH[J].Ann Rheum Dis,2020,79(4):507-517.
50、 BROWN C J,BALLABIO A,RUPERT J L,et al.A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome[J].Nature,1991,349(6304):38-44. BROWN C J,BALLABIO A,RUPERT J L,et al.A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome[J].Nature,1991,349(6304):38-44.
51、 BARTOLOMEI M S,ZEMEL S,TILGHMAN S M.Parental imprinting of the mouse H19 gene[J].Nature,1991,351(6322):153-155. BARTOLOMEI M S,ZEMEL S,TILGHMAN S M.Parental imprinting of the mouse H19 gene[J].Nature,1991,351(6322):153-155.
52、 ZHANG Y,YANG L,CHEN L L.Life without A tail:New formats of long noncoding RNAs[J].Int J Biochem Cell Biol,2014(54):338-349. ZHANG Y,YANG L,CHEN L L.Life without A tail:New formats of long noncoding RNAs[J].Int J Biochem Cell Biol,2014(54):338-349.
53、 GRELET S,LINK L A,HOWLEY B,et al.A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression[J].Nat Cell Biol,2017,19(9):1105-1115. GRELET S,LINK L A,HOWLEY B,et al.A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression[J].Nat Cell Biol,2017,19(9):1105-1115.
54、 DERRIEN T,JOHNSON R,BUSSOTTI G,et al.The GENCODE v7 catalog of human long noncoding RNAs:Analysis of their gene structure,evolution,and expression[J].Genome Res,2012,22(9):1775-1789. DERRIEN T,JOHNSON R,BUSSOTTI G,et al.The GENCODE v7 catalog of human long noncoding RNAs:Analysis of their gene structure,evolution,and expression[J].Genome Res,2012,22(9):1775-1789.
55、 SLACK F J,CHINNAIYAN A M.The Role of Non-coding RNAs in Oncology[J].Cell,2019,179(5):1033-55. SLACK F J,CHINNAIYAN A M.The Role of Non-coding RNAs in Oncology[J].Cell,2019,179(5):1033-55.
56、 BARTEL D P.MicroRNAs:Target recognition and regulatory functions[J].Cell,2009,136(2):215-233. BARTEL D P.MicroRNAs:Target recognition and regulatory functions[J].Cell,2009,136(2):215-233.
57、 LING H,FABBRI M,CALIN G A.MicroRNAs and other non-coding RNAs as targets for anticancer drug development[J].Nat Rev Drug Discov,2013,12(11):847-865. LING H,FABBRI M,CALIN G A.MicroRNAs and other non-coding RNAs as targets for anticancer drug development[J].Nat Rev Drug Discov,2013,12(11):847-865.
58、 VENTER J C,ADAMS M D,MYERS E W,et al.The sequence of the human genome[J].Science(New York,NY),2001,291(5507):1304-1351. VENTER J C,ADAMS M D,MYERS E W,et al.The sequence of the human genome[J].Science(New York,NY),2001,291(5507):1304-1351.
59、 LANDER E S,LINTON L M,BIRREN B,et al.Initial sequencing and analysis of the human genome[J].Nature,2001,409(6822):860-921. LANDER E S,LINTON L M,BIRREN B,et al.Initial sequencing and analysis of the human genome[J].Nature,2001,409(6822):860-921.
60、 RUIZ-BA?OBRE J,GOEL A.DNA Mismatch Repair Deficiency and Immune Checkpoint Inhibitors in Gastrointestinal Cancers[J].Gastroenterology,2019,156(4):890-903. RUIZ-BA?OBRE J,GOEL A.DNA Mismatch Repair Deficiency and Immune Checkpoint Inhibitors in Gastrointestinal Cancers[J].Gastroenterology,2019,156(4):890-903.
61、 HUANG J,LUCERO-PRISNO D E 3rd,ZHANG L,et al.Updated epidemiology of gastrointestinal cancers in East Asia[J].Nat Rev Gastroenterol Hepatol,2023,20(5):271-287. HUANG J,LUCERO-PRISNO D E 3rd,ZHANG L,et al.Updated epidemiology of gastrointestinal cancers in East Asia[J].Nat Rev Gastroenterol Hepatol,2023,20(5):271-287.
62、 ENG C,YOSHINO T,RUíZ-GARCíA E,et al.Colorectal cancer[J].Lancet,2024,404(10449):294-310. ENG C,YOSHINO T,RUíZ-GARCíA E,et al.Colorectal cancer[J].Lancet,2024,404(10449):294-310.
下一篇
出版者信息








《广州医药》公众号
目录