某净水公司职工脂肪肝检出情况及影响因素分析

来源期刊：广州医药 | 1456-1463 发布时间：2025-01-08 收稿时间：2025/11/13 18:42:21 阅读量：26

作者：: 吴琼,

宋慧东,

汤永翔,

肖清华,

吴彩平,

吴坚坚,

关键词：: 净水公司脂肪肝影响因素职业危害因素; water purification company fatty liver disease influencing factors occupational hazard factors

DOI：: 10.20223/j.cnki.1000-8535.2024.12.011

收稿时间：: 2024-07-18
修订日期：
接收日期：
引用总数：: 1

目的了解广州市某净水公司职工脂肪肝检出情况,并分析影响因素。方法选取2023年广州市某净水公司参加职业健康检查的职工为研究对象,收集研究对象的一般情况、个人史、职业史、身体质量指数（BMI）、血压、血生化指标、肝脏彩超等资料。对该人群脂肪肝的患病情况进行描述性分析,对脂肪肝的影响因素进行单因素及多因素Logistic回归分析。结果共收集研究对象1 217人,检出脂肪肝543例,检出率为44.62%。单因素分析结果表明,脂肪肝的发生与性别、年龄、体质量指数、高血压相关（P<0.05）。接触硫化氢、氨的职工脂肪肝检出率高于非接触者（P<0.05）,且职工工龄越长,脂肪肝检出率越高（P<0.05）。患脂肪肝职工的肝功能、脂代谢、血糖及尿酸水平高于非脂肪肝者（P<0.05）。多因素Logistic回归分析提示,年龄、体质量指数、肝功能异常、脂代谢异常、高血糖、高尿酸是脂肪肝的影响因素（P<0.05）。结论广州市某净水公司职工的脂肪肝检出率较高,脂肪肝的发生主要与年龄、体质量指数、肝功能异常、脂代谢异常、高血糖、高尿酸等因素相关。

Objective To investigate the prevalence of fatty liver disease and influencing factors among employees of a water purification company in Guangzhou．Methods Employees of a water purification company in Guangzhou who participated in occupational health examinations in 2023 were selected as the study subjects．The subjects' general conditions,personal history,occupational history,BMI,blood pressure,blood biochemical indicators,and liver ultrasound images were collected．Descriptive analysis was used to analyze the prevalence of fatty liver disease in this population．The influencing factors of fatty liver were analyzed by single factor and multiple factor Logistic regression．Results A total of 1 217 subjects were included in this study,and 543 were diagnosed as fatty liver disease,with a detection rate of 44.62%．The results of single factor analysis showed that the occurrence of fatty liver was closely related to gender,age,BMI and hypertension（P<0.05）．The analysis of occupational hazard factors showed that,the detection rate of fatty liver disease was higher in people exposed to hydrogen sulfide and ammonia compared to non-exposed individuals（P<0.05）．The longer the working years,the higher the detection rate of fatty liver（P<0.05）．The levels of liver function,lipid metabolism,blood glucose and uric acid in workers with fatty liver were higher than those in workers without fatty liver（P<0.05）．Multivariate Logistic regression analysis showed that age,BMI,abnormal liver function,abnormal lipid metabolism,high blood glucose levels and hyperuricemia were independent influencing factors for fatty liver disease（P<0.05）．Conclusions The detection rate of fatty liver disease among employees of a water purification company in Guangzhou is high,and the occurrence of fatty liver disease is mainly related to factors such as age,BMI,abnormal liver function,abnormal lipid metabolism,high sugar levels and hyperuricemia．

1、 LANASPA M A,SANCHEZ-LOZADA L G,CHOI Y J,et al.Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress:Potential role in fructose-dependent and-independent fatty liver[J].J Biol Chem,2012,287(48):40732-40744.

2、刘俊莲. 血脂、血糖联合肝功能检验在非酒精性脂肪肝诊断中的应用价值分析[J].现代诊断与治疗,2021,32(10):1640-1641.

3、孙海燕. 非酒精性脂肪肝患者血生化指标、饮食及行为特征研究[J].华南预防医学,2020,46(6):605-608.

4、陈明霞,王昌高,邓照军.定安县体检人群脂肪肝发生现状及影响因素[J].华南预防医学,2022,48(8):1017-1020.

5、章雅南,刘奕婷.沈阳市健康体检人群非酒精性脂肪肝患病情况及影响因素[J].公共卫生与预防医学,2019,30(3):67-70.

6、莫石柯. 肝硬化合并糖尿病患者胰岛素抵抗与肝功能关系研究[J].中国实用医药,2021,16(11):105-107.

7、邓宗奎,植懿丹,林华玲,等.健康体检人群脂肪肝与高血糖、高血脂、肝功能异常关系的研究[J].中国疗养医学,2014,23(8):676-678.

8、 LI L,LIU D W,YAN H Y,et al.Obesity is an independent risk factor for non-alcoholic fatty liver disease:Evidence from a meta-analysis of 21 cohort studies[J].Obes Rev,2016,17(6):510-519.

9、孔晓丽,王广宇,徐春军,等.男女两性脂肪肝患病率随年龄变化的特征性分析[J].胃肠病学和肝病学杂志,2014,23(9):1061-1065.

10、安晓兰. 脂肪肝和高血脂与性别及年龄的相关分析[J].甘肃科技,2018,34(24):156-157.

11、吴挺丰,廖献花,钟碧慧.中国部分地区非酒精性脂肪肝病的流行情况[J].临床肝胆病杂志,2020,36(6):1370-1373.

12、 KUNG M L,CHENG S M,WANG Y H,et al.Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice[J].Commun Biol,2024,7(1):594.

13、 YOUNOSSI Z M,GOLABI P,PAIK J M,et al.The global epidemiology of nonalcoholic fatty liver disease(NAFLD)and nonalcoholic steatohepatitis(NASH):A systematic review[J].Hepatology,2023,77(4):1335-1347.

14、 BORGHI C,DOMIENIK-KAR?OWICZ J,TYKARSKI A,et al.Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk:2021 update[J].Cardiol J,2021,28(1):1-14.

15、中华医学会糖尿病学分会.中国2型糖尿病防治指南(2020年版)(上)[J].中国实用内科杂志,2021,41(8):668-695.

16、雷婷,刘洋,卜慧颖,等.健康体检人员脂肪肝检出率及相关危险因素分析[J].新疆医学,2023,53(12):1458-1461.

17、 USHIDA T,KOTANI T,KINOSHITA F,et al.Liver transaminase levels during pregnancy:A Japanese multicenter study[J].J Matern Fetal Neonatal Med,2022,35(25):5761-5767.

18、邱秀君,陈越,冯文才.药物服务干预对老年高血压患者的治疗及用药安全性的影响[J].广州医药,2023,54(12):49-54.

19、王文,隋辉,陈伟伟.《中国高血压基层管理指南》要点解读[J].中国实用内科杂志,2015,35(4):317-319.

20、国家卫生健康委员会疾病预防控制局.中国成人超重和肥胖预防控制指南-2021[M].北京:人民卫生出版社,2021.

21、中华中医药学会脾胃病分会.非酒精性脂肪性肝病中医诊疗指南(基层医生版)[J].中西医结合肝病杂志,2019,29(5):后插3-后插6.

22、 GONZáLEZ-RIVERA A,VARGAS-FIGUEROA V M,CANDAL-RIVERA E,et al.Prevalences of hypertension,type 2 diabetes mellitus,and cardiovascular disease in a cohort of Puerto Ricans with non-alcoholic fatty liver disease[J].P R Health Sci J,2024,43(1):18-24.

23、李萍,刘白灵,冼彩连,等.非酒精性脂肪肝患者昼夜节律特点及相关因素分析[J].广州医药,2020,51(4):85-88.

24、 MEI E H,YAO C,CHEN Y N,et al.Multifunctional role of oral bacteria in the progression of non-alcoholic fatty liver disease[J].World J Hepatol,2024,16(5):688-702.

25、 WONG V W,WONG G L,WOO J,et al.Impact of the new definition of metabolic associated fatty liver disease on the epidemiology of the disease[J].Clin Gastroenterol Hepatol,2021,19(10):2161-2171.

26、严磊,李杰,李萌,等.昆明市体检人群脂肪肝患病率及危险因素分析[J].华南预防医学,2023,49(11):1427-1430.

1、朱常青.职业性噪声联合高温作业暴露对职业人群代谢指标的影响[D].广州医科大学,2025.DOI:10.27043/d.cnki.ggzyc.2025.000151.