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《2022 JSC/JSTDM临床实践指南:替考拉宁治疗药物监测》解读

Interpretation of Clinical practice guidelines for therapeutic drug monitoring of teicoplanin: a consensus review by the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

来源期刊: 广州医药 | 24-28 发布时间:2023-02-27 收稿时间:2025/11/13 18:38:27 阅读量:14
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关键词:
替考拉宁治疗药物监测耐甲氧西林金黄色葡萄球菌指南解读目标谷浓度
teicoplaninTDMMRSAguide interpretationCmin" style="padding-right:10px">min')">Cmin
DOI:
10.3969/j.issn.1000-8535.2023.02.004
收稿时间:
2022-02-19 
修订日期:
 
接收日期:
 
引用总数:
6  
目的 为临床合理使用替考拉宁以及更好地管理接受替考拉宁治疗的患者。方法 从药学角度对2022年日本《2022 JSC/JSTDM临床实践指南:替考拉宁治疗药物监测》(简称《指南》)涉及替考拉宁治疗的9个临床问题进行解读。结果 《指南》指出药-时曲线下面积/最小抑菌浓度是替考拉宁的关键药动学/药效学参数。替考拉宁治疗药物监测(TDM)的目的是明确目标谷浓度(Cmin),对于严重或复杂的耐甲氧西林金黄色葡萄球菌(MRSA)感染,指南建议替考拉宁Cmin为20~40 mg/L。肾功能正常或轻度受损的非复杂性的MRSA感染,目标Cmin为15~30 mg/L。严重和/或复杂性MRSA感染,如感染性心内膜炎和骨髓炎,替考拉宁Cmin为20~40 mg/L。结论 《指南》针对不同病理状态下患者替考拉宁目标Cmin的确定,为临床治疗中替考拉宁TDM、个体化给药提供参考。
Objective To make rational use of teicoplanin and better management of patients treated with teicoplanin. Methods Nine clinical issues related to the treatment of teicoplanin in Clinical practice guidelines for therapeutic drug monitoring of teicoplanin: a consensus review by the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring (Japan, 2022) were interpreted from the perspective of pharmacy. Results The guidelines indicated that the area under drug-time curve/minimum inhibitory concentration was the key pharmacokinetic/pharmacodynamic parameters of teicoplanin.The purpose of therapeutic drug monitoring (TDM) of teicoplanin is to specify the target trough concentration (Cmin), which guidelines recommend for severe or complex methicillin-resistant Staphylococcus aureus (MRSA) infection is 20-40 mg/L.The target Cmin for uncomplicated MRSA infection with normal or mildly impaired renal function is 15-30 mg/L.For severe and/or complex MRSA infections, such as infective endocarditis and osteomyelitis, the Cmin of teicoplanin was 20-40 mg/L. Conclusions The guidelines are aimed at the determination of target Cmin of teicoplanin in patients with different pathological conditions, and provide reference for individual drug administration and teicoplanin TDM in clinical treatment.
1、 LIM S K, LEE S A, KIM C-W,et al.High variability of teicoplanin concentration in patients with continuous venovenous hemodiafiltration[J].Hemodial Int,2019,23(1): 69-76. LIM S K, LEE S A, KIM C-W,et al.High variability of teicoplanin concentration in patients with continuous venovenous hemodiafiltration[J].Hemodial Int,2019,23(1): 69-76.
2、 YOSHIDA T, YOSHIDA S, OKADA H,et al.Risk factors for decreased teicoplanin trough concentrations during initial dosing in critically ill patients[J].Pharmazie,2019,74(2): 120-124. YOSHIDA T, YOSHIDA S, OKADA H,et al.Risk factors for decreased teicoplanin trough concentrations during initial dosing in critically ill patients[J].Pharmazie,2019,74(2): 120-124.
3、 BYRNE C J, ROBERTS J A, MCWHINNEY B,et al.Variability in trough totaland unbound teicoplanin concentrations and achievement oftherapeutic drug monitoring targets in adult patients with hematological malignancy[J].Antimicrob Agents Chemother,2017,61(6): e02466-16. BYRNE C J, ROBERTS J A, MCWHINNEY B,et al.Variability in trough totaland unbound teicoplanin concentrations and achievement oftherapeutic drug monitoring targets in adult patients with hematological malignancy[J].Antimicrob Agents Chemother,2017,61(6): e02466-16.
4、 KIM S-H, KANG C-I, HUH K,et al.Evaluating the optimal dose of teicoplanin with therapeutic drug monitoring: not too high for adverse event, not too low for treatment efficacy[J].Eur J Clin Microbiol Infect Dis,2019,38(11): 2113-2120. KIM S-H, KANG C-I, HUH K,et al.Evaluating the optimal dose of teicoplanin with therapeutic drug monitoring: not too high for adverse event, not too low for treatment efficacy[J].Eur J Clin Microbiol Infect Dis,2019,38(11): 2113-2120.
5、 LI H, GAO L, ZHOU L,et al.Optimal teicoplanin loading regimen to rapidly achieve target trough plasma concentration in critically ill patients[J].Basic Clin Pharmacol Toxicol,2020,126(3): 277-288. LI H, GAO L, ZHOU L,et al.Optimal teicoplanin loading regimen to rapidly achieve target trough plasma concentration in critically ill patients[J].Basic Clin Pharmacol Toxicol,2020,126(3): 277-288.
6、 KONTOU A, SARAFIDIS K, BEGOU O,et al.Population pharmacokinetics of teicoplanin in preterm and term neonates: is it time for a new dosing regimen?[J].Antimicrob Agents Chemother,2020, 64(4): e01971-19. KONTOU A, SARAFIDIS K, BEGOU O,et al.Population pharmacokinetics of teicoplanin in preterm and term neonates: is it time for a new dosing regimen?[J].Antimicrob Agents Chemother,2020, 64(4): e01971-19.
7、 TSUTSUURA M, MORIYAMA H, KOJIMA N,et al.The monitoring of vancomycin: a systematic review and meta-analyses of area under theconcentration-time curve-guided dosing and trough-guided dosing[J].BMC Infect Dis,2021, 21(1):153. TSUTSUURA M, MORIYAMA H, KOJIMA N,et al.The monitoring of vancomycin: a systematic review and meta-analyses of area under theconcentration-time curve-guided dosing and trough-guided dosing[J].BMC Infect Dis,2021, 21(1):153.
8、 ODA K, HASHIGUCHI Y, KIMURA T,et al.Performance of area under theconcentration-time curve estimations of vancomycin with limited sampling by a newly developed web application[J].Pharm Res,2021, 38(4):637-646. ODA K, HASHIGUCHI Y, KIMURA T,et al.Performance of area under theconcentration-time curve estimations of vancomycin with limited sampling by a newly developed web application[J].Pharm Res,2021, 38(4):637-646.
9、 HEINE R T, KEIZER R J, van STEEG K,et al.Prospective validation of amodel-informed precision dosing tool for vancomycin in intensive carepatients[J].Br J Clin Pharmacol,2020,86(12): 2497-2506. HEINE R T, KEIZER R J, van STEEG K,et al.Prospective validation of amodel-informed precision dosing tool for vancomycin in intensive carepatients[J].Br J Clin Pharmacol,2020,86(12): 2497-2506.
10、 WICHA S G, M?RTSON A-G, NIELSEN E I,et al.From therapeutic drug monitoring to model-informed precision dosing for antibiotics[J].Clin Pharmacol Ther,2021,109(4): 928-941. WICHA S G, M?RTSON A-G, NIELSEN E I,et al.From therapeutic drug monitoring to model-informed precision dosing for antibiotics[J].Clin Pharmacol Ther,2021,109(4): 928-941.
11、 RAMOS-MARTíN V, JOHNSON A, MCENTEE L,et al.Pharmacodynamics of teicoplanin against MRSA[J].J Antimicrob Chemother,2017, 72(12): 3382-3389. RAMOS-MARTíN V, JOHNSON A, MCENTEE L,et al.Pharmacodynamics of teicoplanin against MRSA[J].J Antimicrob Chemother,2017, 72(12): 3382-3389.
12、 MATSUMOTO K, WATANABE E, KANAZAWA N, et al.Pharmacokinetic/pharmacodynamic analysis of teicoplanin in patients with MRSA infections[J].Clin Pharmacol,2016(8): 15-18. MATSUMOTO K, WATANABE E, KANAZAWA N, et al.Pharmacokinetic/pharmacodynamic analysis of teicoplanin in patients with MRSA infections[J].Clin Pharmacol,2016(8): 15-18.
13、 WATANABE E, MATSUMOTO K, IKAWA K,et al.Pharmacokinetic/pharmacodynamic evaluation of teicoplanin against Staphylococcus aureus in amurine thigh infection model[J].J Glob Antimicrob Resist,2021(24): 83-87. WATANABE E, MATSUMOTO K, IKAWA K,et al.Pharmacokinetic/pharmacodynamic evaluation of teicoplanin against Staphylococcus aureus in amurine thigh infection model[J].J Glob Antimicrob Resist,2021(24): 83-87.
14、 HANAI Y, TAKAHASHI Y, NIWA T,et al.Optimal trough concentration of teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus infection: a systematic review and meta-analysis[J].J Clin Pharm Ther,2021,46(3): 622-632. HANAI Y, TAKAHASHI Y, NIWA T,et al.Optimal trough concentration of teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus infection: a systematic review and meta-analysis[J].J Clin Pharm Ther,2021,46(3): 622-632.
15、 UEDA T, TAKESUE Y, NAKAJIMA K, et al.Clinical efficacy and safety inpatients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days[J].BMC Pharmacol Toxicol,2020, 21(1): 50. UEDA T, TAKESUE Y, NAKAJIMA K, et al.Clinical efficacy and safety inpatients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days[J].BMC Pharmacol Toxicol,2020, 21(1): 50.
1、徐红艳.万古霉素相关急性肾损伤危险因素识别及风险预测研究[D].安徽医科大学,2024.DOI:10.26921/d.cnki.ganyu.2024.001299. 徐红艳.万古霉素相关急性肾损伤危险因素识别及风险预测研究[D].安徽医科大学,2024.DOI:10.26921/d.cnki.ganyu.2024.001299.
2、王宇琨.替考拉宁在重症患者中血药浓度监测及个体化用药研究[D].延边大学,2024.DOI:10.27439/d.cnki.gybdu.2024.001258. 王宇琨.替考拉宁在重症患者中血药浓度监测及个体化用药研究[D].延边大学,2024.DOI:10.27439/d.cnki.gybdu.2024.001258.
3、陈静,陈璐,张丽娟,等.人工神经网络在治疗药物监测中的应用[J].医药导报,2024,43(08):1347-1354. 陈静,陈璐,张丽娟,等.人工神经网络在治疗药物监测中的应用[J].医药导报,2024,43(08):1347-1354.
4、徐吟秋,王晶,申越,等.重症患者使用维持剂量后替考拉宁血药谷浓度明显升高的相关因素分析[J].中国医院药学杂志,2024,44(10):1174-1178.DOI:10.13286/j.1001-5213.2024.10.10. 徐吟秋,王晶,申越,等.重症患者使用维持剂量后替考拉宁血药谷浓度明显升高的相关因素分析[J].中国医院药学杂志,2024,44(10):1174-1178.DOI:10.13286/j.1001-5213.2024.10.10.
5、李晓晶,孙强,王根柱,等.老年重症患者替考拉宁血药浓度影响因素分析[J].临床药物治疗杂志,2024,22(07):52-55. 李晓晶,孙强,王根柱,等.老年重症患者替考拉宁血药浓度影响因素分析[J].临床药物治疗杂志,2024,22(07):52-55.
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