兔VX2移植瘤内间质液压的分布异质性

来源期刊：广州医药 | 26-31 发布时间：2024-01-10 收稿时间：2025/11/13 18:27:54 阅读量：77

作者：: 陈丽萍,

柳建华,

黎昱材,

陈俏利,

何杨成,

冯玉仪,

翁沛华,

胡志文,

关键词：: VX2移植瘤超声针芯法间质液压异质性; VX2 transplanted tumor ultrasound WIN method interstitial fluid pressure heterogeneity

DOI：: 10.3969/j.issn.1000-8535.2023.12.004

收稿时间：: 2023-08-23
修订日期：
接收日期：
引用总数：: 0

目的探索实体肿瘤内部不同区域的间质液压（IFP）分布的异质性。方法通过建立新西兰大白兔的皮下浅肌层VX2移植瘤模型,通过超声造影观察肿瘤的大小、形状、血流灌注等成瘤情况,并在超声引导下通过针芯法（WIN法）测量41只荷瘤兔VX2移植瘤内部不同区域的IFP。结果 41只荷瘤兔的VX2移植瘤的中央IFP为（23.79±8.07） mmHg、肿瘤外周1/2IFP为（15.58±5.22）mmHg、肿瘤外周1/4IFP为（8.29±5.47）mmHg,IFP从中央到外周逐步降低（F=70.85,P<0.001）。结论 VX2移植瘤内不同区域的IFP存在异质性,即从中央到外周IFP呈梯度显著降低。

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