Objective To compare and analyze CT imaging features differences between Mycobacterium intracellulare pulmonary disease and Mycobacterium kansasii pulmonary disease. Methods The CT images of 70 cases with Mycobacterium intracellulare lung disease(group A) and 70 cases with Mycobacterium kansasii lung disease(group B)were collected. The CT features of the two groups were compared by statistical analysis. Results The differences of gender and age between the two groups were statistically significant. The central nodule and tree-in-bud, nodule, thick wall cavity and bronchiectasis incidences in group A were more than those in group B. The thin wall cavity incidence in group A was less than those in group B. The number of cavities in the upper and lower lobe of the right lung in group A was bigger than group B,and the proportion of bronchiectasis in the middle lobe of the right lung in group A was less than those of group B. The bronchiectasis in the middle, lower lobe of right lung and upper lobe lingual segment and lower lobe of left lung in group A were more than those in group B. Conclusion The pulmonary lesion number of Mycobacterium intracellulare was bigger than that of Mycobacterium kansasii, especially bronchiectasis. The thin wall cavity of Mycobacterium kansasii pulmonary disease is more obvious.