天津市三级综合医院疫情期间医护人员代谢综合征与高同型半胱氨酸血症的关系及靶器官损害的研究

来源期刊：广州医药 | 11-16 发布时间：2022-10-11 收稿时间：2025/11/13 18:16:51 阅读量：19

作者：: 王伟占,

王亚莎,

贺晶,

李广阔,

刘勇,

关键词：: 代谢综合征高同型半胱氨酸血症患病率靶器官损害; metabolic syndrome hyperhomocysteinemia prevalence target organ damage

DOI：: 10.3969/j.issn.1000-8535.2022.05.002

收稿时间：: 2022-01-07
修订日期：
接收日期：
引用总数：: 1

目的了解疫情期间医护人员代谢综合征(MS)、高同型半胱氨酸血症(HHcy)的患病率、二者关系及靶器官损害。方法选取2020年1月—2021年11月在天津市某三级综合医院的1 544名医护人员作为研究对象。测量人体指标,测定血液生化、免疫等指标。分析MS及其组分的患病率、HHcy的患病率及靶器官损害。采用χ²检验,比较MS组、HHcy组与对照组靶器官损害的差异。采用Logistic回归模型分析MS与HHcy的关系。结果三级综合医院医护人员疫情期间MS患病率为23.7%,MS组分:中心性肥胖、高血压/高血压病、高甘油三酯、低高密度脂蛋白和高空腹葡萄糖/糖尿病的患病率分别为49.4%、19.3%、24.3%、0.5%和37%。HHcy的患病率为29.7%。MS组、HHcy组与对照组靶器官损害程度差异有统计学意义(P<0.001)。HHcy与MS无直接相关性。结论疫情期间医护人员MS和HHcy患病率较高,与对照组相比有明显的靶器官损害,HHcy不是MS的独立危险因素。

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