Objective To investigate the therapeutic effect of portable endoscopic video system assisted nasopharynx examination. Methods From January 1, 2019 to December 31, 2019, 168 patients in the department of ophthalmology, otorhino-maxillofacial surgery in our hospital were selected as the research objects. The patients were randomly divided into 84 cases. The experimental group used the self-developed portable endoscope video system, while the control group used the traditional laryngoscope system. The treatment effect, satisfaction of medical staff and satisfaction of patients in the process of examination and treatment were compared between the two groups, and the effect was evaluated. Results Compared to the treatment time of nasopharynx and laryngoscope system between the two groups, the experimental group time was 13.4 min; the control group time was 22.9 min; the patients' satisfaction with nasopharyngoscope system examination and treatment was mainly evaluated from the examination and treatment effect, the experimental group satisfaction was 91.67%, while the control group was 86.91%, the difference was statistically significant (χ²=4.695, P=0.030); medical staffs' satisfaction evaluation on the use of nasopharynx and laryngoscope system in the two groups was mainly evaluated from the performance parameters, examination and treatment effect, and the performance parameters mainly included portability, image quality, operation methods, operating costs and other aspects. The satisfaction of the experimental group was 92%, and that of the control group was 77%. The difference between the two groups was statistically significant (χ²=6.834, P=0.009). Conclusion The portable endoscopic video system is easy to operate use. It can not only meet the needs of patients and reduce the diagnosis and treatment time of patients, but also meet the portability of medical staffs in the process of using, and can improve the quality of medical treatment, which is very suitable for clinical use.