微泡超声空化在增强微波消融对肝脏肿瘤的热消融效应中的价值

来源期刊：广州医药 | 43-48 发布时间：2021-11-22 收稿时间：2025/11/13 18:13:12 阅读量：38

作者：: 胡志文,

萧淑宜,

格桑卓玛,

金海,

董燕,

柳建华,

关键词：: 微泡超声空化微波消融肝癌治疗; Microbubble ultrasound cavitation Microwave ablation Liver cancer Treatment

DOI：: 10.3969/j.issn.1000-8535.2021.01.009

收稿时间：: 2020-08-13
修订日期：
接收日期：
引用总数：: 0

目的通过研究微泡超声空化增强微波消融对兔VX2肿瘤的热消融效应来探究其在肿瘤治疗中的价值。方法 24只肝脏移植瘤兔随机分为空白对照组、单纯超声空化治疗组、单纯微波消融治疗组、超声空化联合微波消融治疗组4组。利用增强超声显示每组治疗前后肿瘤的大小、形状和轮廓并通过温度针来检测治疗区域的局部温度。结果联合治疗组血流灌注缺损最严重,微波消融组和联合治疗组缺损体积分别为1.53±0.20和1.68±0.43(P=0.117);微波消融组以及联合治疗组消融治疗时温度达平台时间分别为(21.7±5.0)s和(10.3±5.0)s(P<0.01),最高温度(℃)分别为100.9±5.0和134.1±6.0(P<0.01)。结论 MWA联合MEUS治疗肝癌可使治疗区局部温度急剧升高至峰值温度,有望提高肝癌治疗效果。

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