Objective To explore the application value of cluster nursing on patients with gastroesophageal reflux disease. Methods 100 patients with gastroesophageal reflux disease were enrolled in this study from January 2018 to December 2019. According to the principle of random and double-blind grouping, the cases were divided into control group and observation group, with 50 cases in each group. The control group was supported by routine nursing,and the observation group was supported by cluster nursing. Then negative emotion, self-management efficacy, quality of life (SF-36) and nursing satisfaction were observed between the two groups. Results The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the observation group were lower than those in the control group (P<0.05). The self-management efficacy in the observation group was higher than that in the control group (P<0.05). The scores of physiological function, psychological function, general health and social function of SF-36 in the observation group were higher than those in the control group (P<0.05). The total satisfaction rate of nursing in the observation group (96%) was higher than that in the control group (84%)(P<0.05). Conclusion The implementation of cluster nursing for patients with gastroesophageal reflux disease can improve patients'negative emotion and clinical symptoms, enhance patients' self-management efficacy and quality of life, and standardize nursing management.