Objective To investigate the menopause symptoms and factors of the premenopausal women in urban areas, and thereby provide theoretical basis for their health care. Methods The research data was collected from 1 013 patients (age between 40-60) in the gynecology clinic and adult traditional Chinese medicine clinic in Guangzhou Women and Children's Medical Center, and the communities in Tian'he and Yue'xiu during February 2019—February 2020. By applying the questionnaire and Kupperman score table, the survey was conducted on the dates of birth, menstruations, times of menarche and menopause, records on pregnancy and childbirth, previously diagnosed diseases, heights, weights, classifications of work, family incomes, and personalities, etc. Results The average age of the 1 013 women was 47.70±4.95. Among them, 267 were with menopause (happening in 49.49±3.26 years old), 458 had regular menstruation, while 288 were with menstrual disorder. In the Kupperman scale, the scores of 392 cases (38.7%) were above 15, which can be diagnosed with menopause symptoms. Among them, the majority (222 cases, 56.63%) were with slight symptoms (15-20 scores), followed by 162 cases (41.33%) with moderate symptoms (21-35 scores), and 8 cases (2.04%) with severe symptoms (above 35 scores) respectively. Logistic regression analysis demonstrated that compared with women having satisfactory family relationship, participants suffering from chronic diseases, menstrual disorder, and poor family relationships, had higher risks of perimenopause. However, it had no relations with the marital status, personalities, working hours, social adaptabilities, and negative life events. Conclusion Guangzhou urban women with menopause symptoms are mainly slight and moderate. Participants with chronic diseases, menstrual disorders and poor family relationships are at a higher risk of having menopause symptoms. Therefore, it is recommended to popularize the knowledge of menopause in the society and attach importance to the maintenance of satisfactory family relationship. When perimenopausal women have relevant symptoms, they should seek medical help in time thus they can smoothly pass the peri-menopausal stage.