低出生体重早产儿应用抗生素后的肠道菌群动态变化

来源期刊：广州医药 | 61-67 发布时间：2021-11-24 收稿时间：2025/11/13 18:09:39 阅读量：79

作者：: 罗梅娟,

胡家奇,

魏颖,

欧巧群,

王丽娜,

张又祥,

关键词：: 低出生体重早产儿肠道菌群抗生素高通量测序; Low birth weight Premature infants Gut microbiota Antibiotics High-throughput sequencing

DOI：: 10.3969/j.issn.1000-8535.2021.03.013

收稿时间：: 2021-01-25
修订日期：
接收日期：
引用总数：: 0

目的观察低出生体重早产儿应用抗生素后肠道菌群的动态变化。方法选取2018年6月—2019年7月在广州市第一人民医院住院的10名低出生体重早产儿,在出生时、出生后1~2周、出生后2~3周、出生后3~4周、出生后4~5周、出生后5~6周时分别收集粪便样本,通过16s高通量测序检测患儿粪便菌群变化并统计分析。结果应用抗生素后的低出生体重早产儿肠道菌群α多样性(Shannon指数、Simpson指数、ACE指数和PD_whole_tree指数)下降(P均<0.05),肠道菌群结构在门、科、属水平均发生改变,其中Alistipes、Bacteroides、Lactobacillus、unidentified_Lachnospiraceae、unidentified_Ruminococcaceae、Alloprevotella、unidentified_Cyanobacteria、Bacillus、Stenotrophomonas和Acinetobacter菌属相对丰度减少(P均<0.05)。结论低出生体重早产儿应用抗生素后肠道菌群多样性下降,肠道菌群结构发生改变,并在抗生素停用后仍持续,针对性补充益生菌或益生元可能有助于肠道菌群恢复稳态。

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