I131联合TSH抑制治疗对术后中高危组甲状腺乳头状癌患者心肌纤维化及心房颤动的影响

来源期刊：广州医药 | 40-44 发布时间：2021-11-23 收稿时间：2025/11/13 18:04:54 阅读量：17

作者：: 汪秀衡,

刘克皝,

刘垚,

胡恒境,

关键词：: 甲状腺乳头状癌促甲状腺激素 I 131 心肌纤维化心房颤动; Papillary thyroid Thyroid-stimulating hormone I 131 Myocardial fibrosis Atrial fibrillation

DOI：: 10.3969/j.issn.1000-8535.2021.04.009

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引用总数：: 0

目的探讨I¹³¹联合促甲状腺激素(TSH)抑制治疗对术后中高危组甲状腺乳头状癌(PTC)患者心肌纤维化及心房颤动(AF)的影响。方法选取2016年8月—2017年8月南华大学附属第一医院收治的因PTC行甲状腺双侧腺叶全切术或近全切除术患者69例,根据复发危险度分层分为中危组(49例)和高危组(20例), 两组患者均行I¹³¹ 联合TSH抑制治疗,治疗后嘱患者3个月进行1次复诊或自觉不适及时复诊,观察患者心血管系统症状、心房颤动及心肌纤维化发生情况,患者治疗前后可溶性基质溶素-2(sST2)、生长分化因子-15(GDF-15)、半乳糖凝集素-3 (GAL-3)及血清乳酸脱氢酶(LDHA)含量变化。结果 I¹³¹联合TSH抑制治疗后患者心房颤动发生率和心肌纤维化相关指标水平明显高于治疗前,且高危组患者治疗后心房颤动发生率和心肌纤维化相关指标水平高于中危组,差异均有统计学意义(P<0.05)。结论 I¹³¹联合TSH抑制治疗会增加PTC患者心肌纤维化和心房颤动的发生概率,且高危组PTC患者心肌纤维化和房颤的发生率高于中危组。

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