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哮喘患者气道炎症表型分布及肺功能分析

Phenotype distribution and lung function analysis of airway inflammation in asthmatic patients

来源期刊: 广州医药 | 61-63 发布时间:2021-12-21 收稿时间:2025/11/13 17:37:50 阅读量:13
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关键词:
哮喘气道炎症表型肺功能
AsthmaPhenotype of airway inflammationLung function
DOI:
10.3969/j.issn.1000-8535.2019.01.015
收稿时间:
2018-07-20 
修订日期:
 
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引用总数:
0  
目的 探讨哮喘患者的气道炎症表型分布及肺功能指标情况。方法 选择226 例哮喘患者为研究对象,其中50 例为重症哮喘,76 例为普通哮喘,对比哮喘患者的气道炎症表型分布情况及患者肺功能指标情况。结果 226 例哮喘患者中,嗜酸性粒细胞型最为常见,占36.73%,之后为中性粒细胞型(31.86%)、混合细胞型(22.12%)、寡细胞型(9.29%);重度哮喘患者中,中性粒细胞型患者肺功能相关指标均低于其它类型的重症患者(P<0.05)。结论 在哮喘气道炎症表型中,最常见的表型为嗜酸性粒细胞型,其中中性粒细胞型的哮喘患者的肺功能最差。
Objective To explore the phenotype distribution and lung function indicators of airway inflammation in asthmatic patients. Methods 226 cases of asthma patients were chosen as the research objects,in which 50 cases of severe asthma,76 cases of asthma,to compare asthma airway inflammation phenotype distribution and lung function index. Results Among 226 asthma patients,eosinophilic granulocytes were the most common,accounting for 36.73%,followed by neutrophilic granulocytes (31.86%),mixed cell types (22.12%) and oligocytes (9.29%). Among patients with severe asthma, the lung function of neutrophil patients was lower than that of other severe patients(P < 0.05). Conclusion Among asthmatic airway inflammatory phenotypes, the most common phenotype is eosinophilic granulocyte type, among which neutrophil asthmatic patients have the worst lung function.
1、 JUNG J W,KIM S H,KWON J W,et al.Clinical characteristics and long-term outcomes related to sputum eosinophilia in Korean asthmatics[J]. Asia Pac Allergy,2011,1(1):16-24. JUNG J W,KIM S H,KWON J W,et al.Clinical characteristics and long-term outcomes related to sputum eosinophilia in Korean asthmatics[J]. Asia Pac Allergy,2011,1(1):16-24.
2、 陈建辉,徐莉,郑玉龙,等. 不同体型肥胖与哮喘患者肺功能、气管和全身炎症及病情控制的相关性[J]. 中华临床营养杂志,2014,22(4):209-212. 陈建辉,徐莉,郑玉龙,等. 不同体型肥胖与哮喘患者肺功能、气管和全身炎症及病情控制的相关性[J]. 中华临床营养杂志,2014,22(4):209-212.
3、 SUN J S,HUANG Z,LIU W F.Changes in the ratio of sputum eosinophils induced by chronic persistent asthma and their relationship to lung function[J]. J Ningxia Med Univ,2015,37(5):588-590. SUN J S,HUANG Z,LIU W F.Changes in the ratio of sputum eosinophils induced by chronic persistent asthma and their relationship to lung function[J]. J Ningxia Med Univ,2015,37(5):588-590.
4、 LI Z P,LING Q L,CUI D P,et al.Chitin enzyme protein expressed in different phenotypes of asthma airway inflammation and its correlation with asthma[J]. Chin J Cin Immunol allergy,2015,9(4) :302-306. LI Z P,LING Q L,CUI D P,et al.Chitin enzyme protein expressed in different phenotypes of asthma airway inflammation and its correlation with asthma[J]. Chin J Cin Immunol allergy,2015,9(4) :302-306.
5、 熊健,赵海金,吕燕华,等. 哮喘患者不同水平呼出气一氧化氮差异性反应气道炎症表型[J]. 中国实用内科杂志,2014,14(s1):53-53. 熊健,赵海金,吕燕华,等. 哮喘患者不同水平呼出气一氧化氮差异性反应气道炎症表型[J]. 中国实用内科杂志,2014,14(s1):53-53.
6、 姚彤,郭红,陈若华. 76例哮喘儿童气道炎症表型分析[J]. 新疆医科大学学报,2018,22(2):153-165. 姚彤,郭红,陈若华. 76例哮喘儿童气道炎症表型分析[J]. 新疆医科大学学报,2018,22(2):153-165.
7、 李文碧. 哮喘患者的气道炎症表型及临床特征研究[J]. 医学临床研究,2016,33(11):2149-2151. 李文碧. 哮喘患者的气道炎症表型及临床特征研究[J]. 医学临床研究,2016,33(11):2149-2151.
8、 王子江. 532例哮喘患者的气道炎症表型及临床特征分析[J]. 山东医药,2016,56(9):46-48. 王子江. 532例哮喘患者的气道炎症表型及临床特征分析[J]. 山东医药,2016,56(9):46-48.
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